Valproic acid increases biliary copper excretion in the rat

Epilepsy Research

Volumn 51, Issue 3, 2002, Pages 279-285

  Kuzuya, Takafumi ^a   Amioka, Katsuo ^a   Nabeshima, Toshitaka ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Biliary excretion; Copper; Intestinal absorption; Recirculating perfusion; Valproic acid

Indexed keywords

COPPER; SODIUM CHLORIDE; VALPROIC ACID;

ARTICLE; BILE FLOW; BILE LEVEL; BILIARY EXCRETION; CONTROLLED STUDY; COPPER BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG EFFECT; HOMEOSTASIS; INTESTINE ABSORPTION; MALE; NONHUMAN; PERFUSION; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; BILE; BILIARY TRACT; COPPER; MALE; PERFUSION; RATS; RATS, WISTAR; TIME FACTORS; VALPROIC ACID;

EID: 0036774960     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(02)00155-9     Document Type: Article

References (23)

1. Bull P.C., Cox D.W. Wilson disease and Menkes disease: new handles on heavy-metal transport. Trends Genet. 10:1994;246-252.
2. Cousins R.J. Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol. Rev. 65:(2):1985;238-309.
3. Dickinson R.G., Harland R.C., Ilias A.M., Rodgers R.M., Kaufman S.N., Lynn R.K., Gerber N. Disposition of valproic acid in the rat: dose-dependent metabolism, distribution, enterohepatic recirculation and choleretic effect. J. Pharmacol. Exp. Ther. 211:1979;583-595.
4. Dickinson, R.G., Harland, R.C., Kaufman, S.N., Lynn, R.K., Gerber, N., 1982. An osmotic explanation for valproic acid induced choleresis in the rat, dog and monkey. Arzneimittelforschung 32 (3), 241-247.
5. Dijkstra M., Kuipers F., Smit E.P., de Vries J., Havinga R., Vonk R.J. Biliary secretion of trace elements and minerals in the rat. J. Hepatol. 13:1991;112-119.
6. Dijkstra M., Vonk R.J., Kuipers F. How dose copper get into bile? new insights into the mechanism(s) of hepatobiliary copper transport. J. Hepatol. 24:1996;109-120.
7. Dijkstra M., Huipers F., Van Den Berg G.J., Havinga R., Vonk R.J. Differences in hepatic processing of dietary and intravenously administered copper in rats. Hepatology. 26:1997;962-966.
8. Fichsel H., Niewerth B., Schlehbusch H. Influence of antiepileptic drugs on copper and ceruloplasmin plasma concentration in epileptic children and juveniles. Oxley J., Janz D., Meinardi H., Antiepileptic Therapy: Chronic Toxicity of Antiepileptic Drugs. 1983;85-90 Raven Press, New York.
9. Fitz J.G. Cellular mechanisms of bile secretion. Hepatology. A Textbook of Liver Disease. 1996;362-376 W.B. Saunders, Philadelphia, PA.
10. Hurd R.W., Van Rinsvelt H.A., Wilder B.J., Karas B.J., Maenhaut W., De Reu L. Selenium, zinc and copper changes with valproic acid: possible relation to drug side effects. Neurology. 34:1984;1393-1395.
11. Jurima-Romet M., Abbott F.S., Tang W., Huang H.S., Whitehouse L.W. Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes. Toxicology. 112:1996;69-85.
12. Kaji M., Ito M., Okuno T., Momoi T., Sasaki H., Yamanaka C., Yorifuji T., Mikawa H. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia. 33:(3):1992;555-557.
13. Kaplowitz N., Eberle D.E., Petrini J., Touloukian J., Corvasce M.C., Kuhlenkamp F. Factors influencing the the efflux of hepatic glutathione into bile in rats. J. Pharmacol. Exp. Ther. 224:1983;141-147.
14. Kuzuya T., Hasegawa T., Shimizu K., Nabeshima T. Effect of anti-epileptic drugs on serum zinc and coper concetrations in epileptic patients. Int. J. Clin. Pharmacol. Ther. Toxicol. 31:(2):1993;61-65.
15. Kuzuya T., Hasegawa T., Ogura Y., Nabeshima T. Effect of transmucosal fluid movement on zinc and copper absorption from the rat small intestine. Clin. Exp. Pharmacol. Physiol. 25:1998;412-416.
16. Liu M.-J., Brouwer K.L.R., Pollack G.M. Pharmacokinetics and pharmacodynamics of valproate analogs in rats. III. Pharmacokinetics of valproic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid in the bile-exteriorized rat. Drug Metab. Dispos. 20:1992;810-815.
17. Palm R., Hallmans G. Zinc and copper metabolism in phenytoin therapy. Epilepsia. 23:1982;453-461.
18. Sugawara N., Lai Y.R., Arizono K., Ariyoshi T. Biliary excretion of exogenous cadmium, and endogenous copper and zinc in the Eisai hyperbilirubinuric (EHB) rat with a near absence of biliary glutathione. Toxicology. 112:1996;87-94.
19. Tang W., Borel A.G., Abbott F.S. Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-s-transferases. Drug Metab. Dispos. 24:1996;436-446.
20. Verrotti A., Basciani F., Trotta D., Pomilio M.P., Morgese G., Chiarelli F. Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy. Epilepsy Res. 48:2002;71-75.
21. Wapnir R.A., Sia M.C. Copper intestinal absorption in the rat: effect of free fatty acids and triglycerides. Proc. Soc. Exp. Biol. Med. 211:1996;381-386.
22. Watkins J.B., Klaassen C.D. Choleretic effect of valproic acid in the rat. Hepatology. 1:1981;341-347.
23. 65zinc absorption in the rat. J. Invest. Dermatol. 71:1978;396-397.