Comparison of the effects of 17β-E2 and progesterone on the expression of osteoprotegerin in normal human osteoblast-like cells

Journal of Endocrinological Investigation

Volumn 25, Issue 9, 2002, Pages 785-790

  Liao, E Y ^a   Luo, Xiang Hang ^a   Su, X ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

17 E2; Osteoblast; Osteoprotegerin; Progesterone

Indexed keywords

ESTRADIOL; ESTROGEN; GESTAGEN; MESSENGER RNA; OSTEOPROTEGERIN; PROGESTERONE; CELL RECEPTOR; GLYCOPROTEIN; TNFRSF11B PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; CELL CULTURE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMAL HUMAN; NORTHERN BLOTTING; OSTEOBLAST; OSTEOLYSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; WESTERN BLOTTING; GENETICS; METABOLISM; MIDDLE AGED;

CELLS, CULTURED; ESTRADIOL; GLYCOPROTEINS; HUMANS; MIDDLE AGED; OSTEOBLASTS; OSTEOPROTEGERIN; PROGESTERONE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER;

EID: 0036771756     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03345513     Document Type: Article

References (17)

1. Turner R.T., Riggs B.L., Spelsberg T.C. Skeletal effects of estrogen. Endocr. Rev. 1994, 16: 275-300.
2. MacNamara P, O'Shaughnessy C., Manduca P., Loughrey H.C. Progesterone receptors are expressed in human osteoblast-like cell lines and in primary human osteoblast cultures. Calcif. Tissue Int. 1995, 57: 436-441.
3. Yasuda H., Shima N., Nakagawa N., et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL Proc. Natl. Acad. Sci. U.S.A. 1998, 95: 3597-602.
4. Yasuda H., Shima N., Nakagawa N., et al. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 1998, 139: 1329-1337.
5. Tomoyasu A., Goto M., Fujise N., et al. Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor. Biochem. Biophys. Res. Commun. 1998, 273: 5117-5123.
6. Mizuno A., Amizuka N., Irie K., et al. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem. Biophys. Res. Commun. 1998, 247: 610-615.
7. Bucay N., Sarosi I., Dunstan C.R., et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 1998, 12: 12608.
8. Simonet W.S., Lacey D.L., Dunstan C.R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997, 89: 309-319.
9. Hofbauer L.C., Khosla S., Dunstan C.R., Lacey D.L., Spelseberg T.C., Riggs B.L. Estrogen stimulates gene expression and protein production of osteoprogerin in human osteoblastic cells. Endocrinology 1999, 140: 4367-4370.
10. Saika M., Inoue D., Kido S., Matsumoto T. 17β-estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-α. Endocrinology 2001, 142: 2205-2212.
11. Eryuan L., Xianghang L. Effect of Effects of 17β-estradiol on the expression of matrix metalloproteinase-1, -2 and tissue inhibitor of metalloproteinase-1 in human osteoblast-like cells cultures. Endocrine 2001, 15: 11-16.
12. Vidal N.O.A., Brandstrom H., Jonsson K.B., Ohlsson C. Osteoprotegerin mRNA is expressed in primary human osteoblast-like cells: down-regulation by glucocorticoids. J. Endocrinol. 1998, 159: 191-195.
13. Hofbauer L.C., Dunstan C.R., Spelsberg T.C., Riggs B.L., Khosla S. Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, Bone morphogenetic protein, and cytokines. Biochem. Biophys. Res. Commun. 1998, 250: 776-781.
14. Jilka R.L. Cytokines, bone remodeling, and estrogen deficiency: a 1998 update. Bone 1998, 23: 75-81.
15. MacNamara P., O'Shaughnessy C., Manduca P., Loughrey H.C. Progesterone receptors are expressed in human osteoblast-like cell lines and in primary human osteoblast cultures. Calcif. Tissue Int. 1995, 57: 436-441.
16. Rifas L., Kenney J.S., Marcelli M., et al. Production of interleukin-6 in human osteoblasts and human bone marrow stromal cells: evidence that induction by interleukin-1 and tumor necrosis factor-α is not regulated by ovarian steroid. Endocrinology 1995, 136: 4056-4067.
17. Schmidt U.I., Wakley G.K., Turner R.T. Effects of estrogen and progesterone on tibia histomorphometry in growing rats. Calcif. Tissue Int. 2000, 67: 47-52.