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36
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0033609985
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Effect of NK-104, a new synthetic HMG-CoA reductase inhibitor, on triglyceride secretion and fatty acid oxidation in rat liver
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359276; note
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359276 Effect of NK-104, a new synthetic HMG-CoA reductase inhibitor, on triglyceride secretion and fatty acid oxidation in rat liver. Yamamoto K, Todaka N, Goto H, Jayaooriya AP, Sakono M, Ogawa Y, Fukuda N Life Sci 1999 65 1493-1502 NK-104 exerts its hypotriglyceridemic action by diverting exogenous free fatty acid to oxidative pathways.
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(1999)
Life Sci
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Yamamoto, K.1
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Jayaooriya, A.P.4
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Ogawa, Y.6
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37
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0032799925
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NK-104, a potent new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, enhances posttranslational catabolism of apolipoprotein B-100 and inhibits secretion of apolipoprotein B-100 and triacylglycerols from HepG2 cells
-
359278
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359278 NK-104, a potent new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, enhances posttranslational catabolism of apolipoprotein B-100 and inhibits secretion of apolipoprotein B-100 and triacylglycerols from HepG2 cells. Yanagita T, Hara E, Yotsumoto H, Rahman SM, Han SY, Cha JY, Yamamoto K Curr Ther Res Clin Exp 1999 60 423-434
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38
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Hypolipidemic effect of NK-104, a potent HMG-CoA reductase inhibitor in guinea pigs
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359281
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359281 Hypolipidemic effect of NK-104, a potent HMG-CoA reductase inhibitor in guinea pigs. Suzuki H, Aoki T, Tamaki T, Sato F, Kitahara M, Saito Y Atherosclerosis 1999 146 259
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39
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Identification of metabolites of NK-104, an HMG-CoA reductase inhibitor in rat, rabbit, and dog bile
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359285
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359285 Identification of metabolites of NK-104, an HMG-CoA reductase inhibitor in rat, rabbit, and dog bile. Kojima J, Fujino H, Abe H, Yosimura M, Kanda H, Kimata H Biol Pharm Bull 1999 22 2 142-150
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(1999)
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40
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0032972446
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NK-104, a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, decreases apolipoprotein B-100 secretion from HepG2 cells
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359287; note
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359287 NK-104, a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, decreases apolipoprotein B-100 secretion from HepG2 cells. Ooyen C, Zecca A, Bersino AM, Catapano AL Atherosclerosis 1999 145 1 87-95 The ability of NK-104 to decrease apolipoprotein B-100 secretion is due to decreased intracellular cholesterol availability.
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41
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Mutagenicity studies of (+)-monocalcium bis [(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-hept anoate] (NK-104)
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359291
-
359291 Mutagenicity studies of (+)-monocalcium bis [(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-hept anoate] (NK-104). Okamura N, Moriwaki T, Yamada H, Koga T, Tanaka M, Oguma Y, Yokota F, Nakajima M, Takimoto M Pharmacometrics 1999 57 1-12
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Effects of NK-104, a new hydroxymethylglutaryl-coenzyme reductase inhibitor, on low density lipoprotein cholesterol in heterozygous familial hypercholesterolemia
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359297
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359297 Effects of NK-104, a new hydroxymethylglutaryl-coenzyme reductase inhibitor, on low density lipoprotein cholesterol in heterozygous familial hypercholesterolemia. Kajinami K, Koizumi J, Ueda K, Miyamoto S, Takegoshi T, Mabuchi H, The Hokuriku NK 104 Study group Am J Cardiol 2000 85 2 178-183
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359299; note
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359299 Studies on the metabolic fate of NK-104, a new inhibitor of HMG-CoA reductase (4): Interspecies variations in laboratory animals and humans. Fujino H, Kojima J, Yamada Y, Kanda H, Kimata H Xenobiot Metab Dispos 1999 14 79-91 NK-104 was hardly metabolized via the cytochrome P450-mediated pathway in humans.
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Pharmaceutical division
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Influences of itavastatin a new HMG-CoA reductase inhibitor on glucose metabolism and LDL size in patients with hyperlipidemia and NIDDM
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Sankyo completes purchase of Sankyo Parke Davis stocks from Pfizer
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SkyePharma selected by Kowa as partner for development of their new statin NK-104
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Novartis acquires European rights to 'super-statin' cholesterol treatment pitavastatin
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NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells
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Novartis bids on "superstatin": Seeking US rights to pitavastatin
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To gain a greater shar in the US first: Mr Shoda of Sankyo
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Novartis R&D Day October 30, 2001
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Sankyo aims at US sales of ¥360 bill in FY2010
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Sankyo planning late pII study on pitavastatin in US
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434148 Inhibition of cholesterol synthesis by pitavastatin, an HMG-CoA RI, in HepG2 cells and a cell-free system of a rat liver: The enzyme specificity of pitavastatin action. Yamazaki H, Morikawa S, Aoki T, Suzuki H, Tamaki T, Sato H, Kitahara M, Saito Y Int Symp on Drugs Affect Lipid Metab 2001 September 9-12 59
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NK-104 inhibits expression of VCAM-1 by endothelial cells and CD36, tissue factor and MM-9 by macrophages
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434198 NK-104 inhibits expression of VCAM-1 by endothelial cells and CD36, tissue factor and MM-9 by macrophages. Hajjar DP, Nicholson AC, Han J, Summers B, Feirt N, Gotto Jr AM Int Symp on Drugs Affect Lipid Metab 2001 September 9-12 104
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Studies of metabolic fate of pitavastatin (NK-104), a new inhibitor of HMG-CoA reductase - Does glucuronidation mediate the lactonization of pitavastatin?
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Analyst report
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448097; December 06
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448097 Analyst report. CDC IXIS Securities 2001 December 06
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CDC IXIS Securities
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Sankyo announces financial results for the year ended March 31, 2002
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451594; May 17
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(2002)
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