Single dose toxicity studies of (+)-monocalcium bis[(3R, 5S, 6E)-7-[2- cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3, 5-dihydroxy 6-heptenoate] * (NK-104) in rats and dogs

Pharmacometrics

Volumn 56, Issue 3-4, 1998, Pages 67-72

  Shibuta, Tetsuo ^a   Kato, Yasushi ^a   Akiba, Tomohide ^a   Ohkubo, Masato ^a   Kakishita, Tomofumi ^a   Tanaka, Masahiro ^a   Takimoto, Masayoshi ^a  

^a KOWA COMPANY LTD   (Japan)

Author keywords

(+) Monocalcium bis (3R, 5S, 6E) 7 2 cyclopropyl 4 (4 fluorophenyl) 3 quinolyl 3, 5 dihydroxy 6 heptenoate *; (rat and dog); HMG CoA Reductase inhibitor; Hypolipidermic agent; Single dose toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; PITAVASTATIN;

ANIMAL TISSUE; ARTICLE; DOG; FEMALE; HISTOPATHOLOGY; HYPERKERATOSIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STOMACH HEMORRHAGE; STOMACH ULCER; TOXICITY;

EID: 0032419622     PISSN: 03008533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Hartman, H.A., Myers, L.A., Evans, M., Robison, R.L., Engstrom, R.G. and Tse, F.L.S. (1996): The safety evaluation of fluvastatin, an HMG-CoA reductase inhibitor, in beagle dogs and rhesus monkeys, Fundam. Appl. Toxicol., 29, 48-62.
2. (1987): Pravastatin sodium 15, 4949-4956.
3. Ronald, S.E. (1990): Simvastatin (MK-0733) 39, 95-101