CMV genome quantification as a diagnostic tool for improving treatment and monitoring of risk patients;Quantifizierung von CMV-DNA als diagnostisches werkzeug zur verbesserten behandlung und überwachung von risikopatienten

LaboratoriumsMedizin

Volumn 26, Issue 9-10, 2002, Pages 486-494

  Fleckenstein, Corinna ^a   Doerr, H W ^a   Preiser, W ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Antiviral drugs; Cytomegalovirus (CMV); Polymerase chain reaction (PCR); Viral nucleic acids; Virus quantification

Indexed keywords

ACICLOVIR; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; NUCLEIC ACID; PENCICLOVIR; VIRUS DNA; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; HIGH RISK PATIENT; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; LABORATORY DIAGNOSIS; NONHUMAN; PATIENT MONITORING; POLYMERASE CHAIN REACTION; PROGNOSIS; RETINITIS; REVIEW; TREATMENT OUTCOME; VIRUS DETECTION; VIRUS GENOME; VIRUS INFECTION; VIRUS ISOLATION;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; DNA VIRUSES;

EID: 0036753552     PISSN: 03423026     EISSN: None     Source Type: Journal    
DOI: 10.1515/LabMed.2002.058     Document Type: Review

References (46)

1. Hebart H, Jahn G, Sinzger C, Kanz L, Einsele H. CMV Infection in Bone Marrow and Solid Organ Transplant Patients in the Era of Antiviral Prophylaxis. Herpes 2000;7(1):13-17.
2. Deayton JR. Changing trends in cytomegalovirus disease in HIV-infected patients. Herpes 2001;8(2):37-40.
3. Griffiths PD, Cope AV, Hassan-Walker AF, Emery VC. Diagnostic approaches to cytomegalovirus infection in bone marrow and organ transplantation. Transpl Infect Dis 1999;1(3):179-186.
4. de Jong MD, Boucher CA, Danner SA, Gazzard B, Griffiths PD, Katlama C, Lange JM, Richman DD, Vella S. Summary of the international consensus symposium on management of HIV, CMV and hepatitis virus infections. Antiviral Res 1998;37(1):1-16.
5. de Jong MD, Galasso GJ, Gazzard B, Griffiths PD, Jabs DA, Kern ER, Spector SA. Summary of the II International Symposium on Cytomegalovirus. Antiviral Res 1998;39(3):141-62.
6. Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002;34(8):1094-1097.
7. Preiser W, Berger A, Doerr HW. Neue Ansätze in der Therapie viraler Erkrankungen. Deutsches Ärzteblatt 2000;97 [Heft50]:A3433-3439.
8. Martin DF, Sierra-Madero J, Walmsley S, Wolitz RA, Macey K, Georgiou P, Robinson CA, Stempien MJ. A controlled trial of valganciclovir as induction therapy for cytomegalovirus retinitis. N Engl J Med 2002;346(15):1119-1126.
9. Gerna G, Percivalle E, Baldanti F, Sarasini A, Zavattoni M, Furione M, Torsellini M, Revello MG. Diagnostic significance and clinical impact of quantitative assays for diagnosis of human cytomegalovirus infection/disease in immunocompromised patients. New Microbiol 1998;21(3):293-308.
10. Berger A, Preiser W. Viral genome quantification as a tool for improving patient management: The example of HIV, HBV, HCV and CMV. J Antimicrob Chemother 2002;49(5):713-21.
11. Weber B, Nestler U, Ernst W, Rabenau H, Braner J, Birkenbach A, Scheuermann EH, Schoeppe W, Doerr HW. Low correlation of human cytomegalovirus DNA amplification by polymerase chain reaction with cytomegalovirus disease in organ transplant recipients. J Med Virol 1994;43(2):187-193.
12. Razonable RR, Paya CV, Smith TF. Role of the laboratory in diagnosis and management of cytomegalovirus infection in hematopoietic stem cell and solid-organ transplant recipients. J Clin Microbiol 2002;40(3):746-752.
13. Grangeot-Keros L, Cointe D. Diagnosis and prognostic markers of HCMV infection. J Clin Virol 2001;21(3):213-221.
14. Boeckh M, Boivin G. Quantitation of cytomegalovirus: Methodologic aspects and clinical applications. Clin Microbiol Rev 1998;11(3):533-554.
15. Preiser W, Brauninger S, Schwerdtfeger R, Ayliffe U, Garson JA, Brink NS, Franck S, Doerr HW, Rabenau HF. Evaluation of diagnostic methods for the detection of cytomegalovirus in recipients of allogeneic stem cell transplants. J Clin Virol 2001;20(1-2):59-70.
16. Vogel JU, Cinatl J, Lux A, Weber B, Driesel AJ, Doerr HW. New PCR assay for rapid and quantitative detection of human cytomegalovirus in cerebrospinal fluid. J Clin Microbiol 1996;34(2):482-3.
17. Preiser W, Elzinger B, Brink NS. Quantitative molecular virology in patient management. J Clin Pathol 2000;53(1):76-83.
18. Preiser W, Rabenau HF, Vogel JU, Brixner V, Doerr HW. Performance characteristics of an automated PCR assay for the quantification of cytomegalovirus DNA in plasma. J Virol Methods 2002;101(1-2):149-157.
19. Griffiths PD, Cope AV, Hassan-Walker AF, Emery VC. Diagnostic approaches to cytomegalovirus infection in bone marrow and organ transplantation. Transpl Infect Dis 1999;1(3):179-186.
20. Revello MG, Zavattoni M, Baldanti F, Sarasini A, Paolucci S, Gerna G. Diagnostic and prognostic value of human cytomegalovirus load and IgM antibody in blood of congenitally infected newborns. J Clin Virol 1999;14(1):57-66.
21. Fox JC, Kidd IM, Griffiths PD, Sweny P, Emery VC. Longitudinal analysis of cytomegalovirus load in renal transplant recipients using a quantitative polymerase chain reaction: Correlation with disease. J Gen Virol 1995;76(Pt 2):309-19.
22. Spector SA, Wong R, Hsia K, Pilcher M, Stempien MJ. Plasma cytomegalovirus (CMV) DNA load predicts CMV disease and survival in AIDS patients. J Clin Invest 1998;101(2):497-502.
23. Emery VC. Investigation of CMV disease in immunocompromised patients. J Clin Pathol 2001;54(2):84-88.
24. Emery VC. Viral dynamics during active cytomegalovirus infection and pathology. Intervirology 1999;42(5-6):405-11.
25. Emery VC, Sabin CA, Cope AV, Gor D, Hassan-Walker AF, Griffiths PD. Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation. Lancet 2000;10;355(9220):2032-6.
26. Goodrich JM, Bowden RA, Fisher L, Keller C, Schoch G, Meyers JD. Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant. Ann Intern Med 1993;118(3):173-8.
27. Winston DJ, Ho WG, Bartoni K, Du Mond C, Ebeling DF, Buhles WC, Champlin RE. Ganciclovir prophylaxis of cytomegalovirus infection and disease in allogeneic bone marrow transplant recipients. Results of a placebo-controlled, double-blind trial. Ann Intern Med 1993;118(3):179-84.
28. Centers for Disease Control and Prevention. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients: Recommendations of CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation. MMWR 2000;49(No. RR-10):1-128.
29. Peggs KS, Preiser W, Kottaridis PD, McKeag N, Brink NS, Tedder RS, Goldstone AH, Linch DC, Mackinnon S. Extended routine polymerase chain reaction surveillance and pre-emptive antiviral therapy for cytomegalovirus after allogeneic transplantation. Br J Haematol 2000;111(3):782-90.
30. Caliendo AM, St George K, Kao SY, Allega J, Tan BH, LaFontaine R, Bui L, Rinaldo CR. Comparison of quantitative cytomegalovirus (CMV) PCR in plasma and CMV antigenemia assay: Clinical utility of the prototype AMPLICOR CMV MONITOR test in transplant recipients. J Clin Microbiol 2000;38(6):2122-2127.
31. Boivin G, Belanger R, Delage R, Beliveau C, Demers C, Goyette N, Roy J. Quantitative analysis of cytomegalovirus (CMV) viremia using the pp65 antigenemia assay and the COBAS AMPLICOR CMV MONITOR PCR test after blood and marrow allogeneic transplantation. J Clin Microbiol 2000;38(12):4356-4360.
32. von Müller L, Hampl W, Hinz J, Meisel H, Reip A, Engelmann E, Heilbronn R, Gartner B, Kramer O, Einsele H, Hebart H, Ljubicic T, Loffler J, Mertens T. High variability between results of different in-house tests for cytomegalovirus (CMV) monitoring and a standardized quantitative plasma CMV PCR assay. J Clin Microbiol 2002;40(6):2285-2287.
33. Chou S. Antiviral drug resistance in human cytomegalovirus. Transpl Infect Dis 1999;1(2):105-114.
34. Emery VC. Progress in understanding cytomegalovirus drug resistance. J Clin Virol 2001;21(3):223-228.
35. Reusser P, Einsele H, Lee J, Volin L, Rovira M, Engelhard D, Finke J, Cordonnier C, Link H, Ljungman P. Randomized multicenter trial of foscarnet versus ganciclovir for preemptive therapy of cytomegalovirus infection after allogeneic stem cell transplantation. Blood 2002;99(4):1159-64.
36. Caliendo AM, Schuurman R, Yen-Lieberman B, Spector SA, Andersen J, Manjiry R, Crumpacker C, Lurain NS, Erice A. Comparison of quantitative and qualitative PCR assays for cytomegalovirus DNA in plasma. J Clin Microbiol 2001;39(4):1334-1338.
37. Pellegrin I, Garrigue I, Binquet C, Chene G, Neau D, Bonot P, Bonnet F, Fleury H, Pellegrin JL. Evaluation of new quantitative assays for diagnosis and monitoring of cytomegalovirus disease in human immunodeficiency virus-positive patients. J Clin Microbiol 1999;37(10):3124-3132.
38. Saldanha J. Validation and standardisation of nucleic acid amplification technology (NAT) assays for the detection of viral contamination of blood and blood products. J Clin Virol 2001;20(1-2):7-13.
39. Preiser W, Brink N S, Ayliffe U, Peggs K, Mackinnon S, Tedder R, Garson J. (2002) Development and clinical application of a fully controlled quantitative PCR assay for cell-free cytomegalovirus in human plasma. J Clin Virol 2002, in press.
40. Tedder RS, Ayliffe U, Preiser W, Brink NS, Grant PR, Peggs KS, Mackinnon S, Kreig-Schneider F, Kirk S, Garson JA. Development and evaluation of an internally controlled semiautomated PCR assay for quantification of cell-free cytomegalovirus. J Med Virol 2002;66(4):518-523.
41. Schutten M, Niesters HG. Clinical utility of viral quantification as a tool for disease monitoring. Expert Rev Mol Diagn 2001;1(2):153-162.
42. Guiver M, Fox AJ, Mutton K, Mogulkoc N, Egan J. Evaluation of CMV viral load using TaqMan CMV quantitative PCR and comparison with CMV antigenemia in heart and lung transplant recipients. Transplantation 2001;71(11):1609-15.
43. Mackay I, Arden K, Nitsche A. Real-time PCR in virology. Nucleic Acids Res 2002;30(6):1292-1305.
44. Niesters HG. Quantitation of viral load using real-time amplification techniques. Methods 2001;25(4):419-429.
45. Gouarin S, Gault E, Vabret A, Cointe D, Rozenberg F, Grangeot-Keros L, Barjot P, Garbarg-Chenon A, Lebon P, Freymuth F. Realtime PCR quantification of human cytomegalovirus DNA in amniotic fluid samples from mothers with primary infection. J Clin Microbiol 2002;40(5):1767-1772.
46. Fleckenstein C, Stürmer M, Preiser W, Doerr H.W. Development of a novel, fully controlled method for quantitative cytomegalovirus genome detection by multiplex real-time PCR ("TaqMan"). J Lab Med 2002;26(3/4):206.