메뉴 건너뛰기




Volumn 63, Issue 9, 2002, Pages 621-633

Effects of orlistat, simvastatin, and orlistat + simvastatin in obese patients with hypercholesterolemia: A randomized, open-label trial

Author keywords

Blood pressure; Diet; Hypercholesterolemia; Obese; Orlistat; Simvastatin

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL;

EID: 0036748432     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(02)80066-2     Document Type: Article
Times cited : (18)

References (51)
  • 2
    • 0030763001 scopus 로고    scopus 로고
    • Science, medicine, and the future: Obesity treatment
    • Wilding J. Science, medicine, and the future: Obesity treatment. BMJ. 1997;315:997-1000.
    • (1997) BMJ , vol.315 , pp. 997-1000
    • Wilding, J.1
  • 3
    • 0032035090 scopus 로고    scopus 로고
    • Burden of illness review of obesity: Are the true costs realised?
    • McIntyre AM. Burden of illness review of obesity: Are the true costs realised? J R Soc Health. 1998;118:76-84.
    • (1998) J R Soc Health , vol.118 , pp. 76-84
    • McIntyre, A.M.1
  • 4
    • 0028917432 scopus 로고
    • Weight gain as a risk factor for clinical diabetes mellitus in women
    • Colditz GA, Willet WC, Rotnitzky A, Mansen JE. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med. 1995;122:481-486.
    • (1995) Ann Intern Med , vol.122 , pp. 481-486
    • Colditz, G.A.1    Willet, W.C.2    Rotnitzky, A.3    Mansen, J.E.4
  • 5
    • 0026507487 scopus 로고
    • Pathophysiology of obesity
    • Bray GA. Pathophysiology of obesity. Am J Clin Nutr. 1992;55(Suppl 2):488S-494S.
    • (1992) Am J Clin Nutr , vol.55 , Issue.SUPPL. 2
    • Bray, G.A.1
  • 6
    • 0020533259 scopus 로고
    • Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study
    • Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983;67:968-977.
    • (1983) Circulation , vol.67 , pp. 968-977
    • Hubert, H.B.1    Feinleib, M.2    McNamara, P.M.3    Castelli, W.P.4
  • 7
    • 0025760610 scopus 로고
    • Diabetes Intervention Study: Multi-intervention trial in newly diagnosed NIDDM
    • Hanefeld M, Fischer S, Schmechel H, et al. Diabetes Intervention Study: Multi-intervention trial in newly diagnosed NIDDM. Diabetes Care. 1991;14:308-317.
    • (1991) Diabetes Care , vol.14 , pp. 308-317
    • Hanefeld, M.1    Fischer, S.2    Schmechel, H.3
  • 8
    • 0025826596 scopus 로고
    • Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations
    • Chen Z, Peto R, Collins R, et al. Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations. BMJ. 1991;303:276-282.
    • (1991) BMJ , vol.303 , pp. 276-282
    • Chen, Z.1    Peto, R.2    Collins, R.3
  • 9
    • 0029166762 scopus 로고
    • Range of serum cholesterol values in the population developing coronary artery disease
    • Kannel WB. Range of serum cholesterol values in the population developing coronary artery disease. Am J Cardiol. 1995;76:69C-77C.
    • (1995) Am J Cardiol , vol.76
    • Kannel, W.B.1
  • 10
    • 0029650740 scopus 로고
    • Cholesterol reduction in cardiovascular disease: Clinical benefits and possible mechanisms
    • Levine GN, Keaney JF Jr, Vita JA. Cholesterol reduction in cardiovascular disease: Clinical benefits and possible mechanisms. N Engl J Med. 1995;332:512-521.
    • (1995) N Engl J Med , vol.332 , pp. 512-521
    • Levine, G.N.1    Keaney J.F., Jr.2    Vita, J.A.3
  • 11
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • Shepherd J, Cobbe SM, Ford I, et al, for the West of Scotland Coronary Prevention Study Group. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med. 1995;333:1301-1307.
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 12
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS Air Force/Texas Coronary Atherosclerosis Prevention Study
    • Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA. 1998;279:1615-1622.
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3
  • 13
    • 0025215317 scopus 로고
    • The effects of simvastatin on plasma lipoproteins and cholesterol homeostasis in patients with heterozygous familial hypercholesterolemia
    • Hagemenas FC, Pappu AS, Illingworth DR. The effects of simvastatin on plasma lipoproteins and cholesterol homeostasis in patients with heterozygous familial hypercholesterolemia. Eur J Clin Invest. 1990;20:150-157.
    • (1990) Eur J Clin Invest , vol.20 , pp. 150-157
    • Hagemenas, F.C.1    Pappu, A.S.2    Illingworth, D.R.3
  • 14
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 15
    • 0033069767 scopus 로고    scopus 로고
    • 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension
    • Guidelines Subcommittee
    • 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee. J Hypertens. 1999;17:151-183.
    • (1999) J Hypertens , vol.17 , pp. 151-183
  • 16
    • 0028103894 scopus 로고
    • Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers
    • Zhi J, Melia AT, Guerciolini R, et al. Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers. Clin Pharmacol Ther. 1994;56:82-85.
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 82-85
    • Zhi, J.1    Melia, A.T.2    Guerciolini, R.3
  • 17
    • 0023811877 scopus 로고
    • HMG-CoA reductase inhibitors for hypercholesterolemia
    • HMG-CoA reductase inhibitors for hypercholesterolemia. N Engl J Med. 1988;319:1222-1223.
    • (1988) N Engl J Med , vol.319 , pp. 1222-1223
  • 18
    • 0025077819 scopus 로고
    • Simvastatin: A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia
    • Todd PA, Goa KL. Simvastatin: A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1990;40:583-607.
    • (1990) Drugs , vol.40 , pp. 583-607
    • Todd, P.A.1    Goa, K.L.2
  • 19
    • 0027463867 scopus 로고
    • Combination drug therapy for dyslipidemia
    • Betteridge DJ. Combination drug therapy for dyslipidemia. Curr Opin Lipidol. 1993;4:49-55.
    • (1993) Curr Opin Lipidol , vol.4 , pp. 49-55
    • Betteridge, D.J.1
  • 20
    • 0026042196 scopus 로고
    • Effect of simvastatin and fenofibrate on the fatty acid composition of hypercholesterolaemic patients
    • Agheli N, Jacotot B. Effect of simvastatin and fenofibrate on the fatty acid composition of hypercholesterolaemic patients. Br J Clin Pharmacol. 1991;32:423-428.
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 423-428
    • Agheli, N.1    Jacotot, B.2
  • 21
    • 0028273352 scopus 로고
    • Comparative efficacy and safety of micronized fenofibrate and simvastatin in patients with primary type IIa or IIb hyperlipidemia
    • Farnier M, Bonnefous F, Debbas N, Irvine A. Comparative efficacy and safety of micronized fenofibrate and simvastatin in patients with primary type IIa or IIb hyperlipidemia. Arch Intern Med. 1994;154:441-449.
    • (1994) Arch Intern Med , vol.154 , pp. 441-449
    • Farnier, M.1    Bonnefous, F.2    Debbas, N.3    Irvine, A.4
  • 22
    • 0025325330 scopus 로고
    • Weight change in middle-aged British men: Implications for health
    • Wannamethee G, Shaper AG. Weight change in middle-aged British men: Implications for health. Eur J Clin Nutr. 1990;44:133-142.
    • (1990) Eur J Clin Nutr , vol.44 , pp. 133-142
    • Wannamethee, G.1    Shaper, A.G.2
  • 23
    • 0026597996 scopus 로고
    • Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: Results of one year follow up
    • Singh RB, Rastogi SS, Vermi R, et al. Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: Results of one year follow up. BMJ. 1992;304:1015-1019.
    • (1992) BMJ , vol.304 , pp. 1015-1019
    • Singh, R.B.1    Rastogi, S.S.2    Vermi, R.3
  • 24
    • 0026753155 scopus 로고
    • Beneficial health effects of modest weight loss
    • Goldstein DJ. Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord. 1992;16:397-415.
    • (1992) Int J Obes Relat Metab Disord , vol.16 , pp. 397-415
    • Goldstein, D.J.1
  • 25
    • 0029015738 scopus 로고
    • Waist circumference as a measure for indicating need for weight management
    • Lean ME, Han TS, Morrison CE. Waist circumference as a measure for indicating need for weight management. BMJ. 1995;311:158-161.
    • (1995) BMJ , vol.311 , pp. 158-161
    • Lean, M.E.1    Han, T.S.2    Morrison, C.E.3
  • 26
    • 0032477331 scopus 로고    scopus 로고
    • Abdominal adiposity and coronary heart disease in women
    • Rexrode KM, Carey VJ, Hennekans CH, et al. Abdominal adiposity and coronary heart disease in women. JAMA. 1999;280:1843-1848.
    • (1999) JAMA , vol.280 , pp. 1843-1848
    • Rexrode, K.M.1    Carey, V.J.2    Hennekans, C.H.3
  • 27
    • 0032543870 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients
    • Sjostrom L, Rissanen A, Andersen T, et al, for the European Multicentre Orlistat Study Group. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Lancet. 1998;352:167-172.
    • (1998) Lancet , vol.352 , pp. 167-172
    • Sjostrom, L.1    Rissanen, A.2    Andersen, T.3
  • 28
    • 0033629936 scopus 로고    scopus 로고
    • Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity
    • Rossner S, Sjostrom L, Noack R, et al, for the European Orlistat Obesity Study Group. Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity. Obes Res. 2000;8:49-61.
    • (2000) Obes Res , vol.8 , pp. 49-61
    • Rossner, S.1    Sjostrom, L.2    Noack, R.3
  • 29
    • 0010803472 scopus 로고    scopus 로고
    • Effect of weight loss treatment with orlistat on blood pressure and heart rate among obese patients
    • Van Gaal L, Mertens I, Peiffer F, et al. Effect of weight loss treatment with orlistat on blood pressure and heart rate among obese patients [abstract]. Obes Res. 1999;7(Suppl 1):O205.
    • (1999) Obes Res , vol.7 , Issue.SUPPL. 1
    • Van Gaal, L.1    Mertens, I.2    Peiffer, F.3
  • 30
    • 0032408205 scopus 로고    scopus 로고
    • Treatment with orlistat reduces cardiovascular risk in obese patients
    • Zavoral JH. Treatment with orlistat reduces cardiovascular risk in obese patients. J Hypertens. 1998;16:2013-2017.
    • (1998) J Hypertens , vol.16 , pp. 2013-2017
    • Zavoral, J.H.1
  • 31
    • 0031611941 scopus 로고    scopus 로고
    • Effects of lipid-lowering agents in the Dahl salt-sensitive rat
    • Wilson TW, Alonso-Galicia M, Roman RJ. Effects of lipid-lowering agents in the Dahl salt-sensitive rat. Hypertension. 1998;31:225-231.
    • (1998) Hypertension , vol.31 , pp. 225-231
    • Wilson, T.W.1    Alonso-Galicia, M.2    Roman, R.J.3
  • 32
    • 0030809963 scopus 로고    scopus 로고
    • Lovastatin prevents development of hypertension in spontaneously hypertensive rats
    • Jiang J, Roman RJ. Lovastatin prevents development of hypertension in spontaneously hypertensive rats. Hypertension. 1997;30:968-974.
    • (1997) Hypertension , vol.30 , pp. 968-974
    • Jiang, J.1    Roman, R.J.2
  • 33
    • 0035979347 scopus 로고    scopus 로고
    • Amelioration of angiotensin II-induced cardiac injury by a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
    • Dechend R, Fiebeler A, Park JK, et al. Amelioration of angiotensin II-induced cardiac injury by a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Circulation. 2001;104:576-581.
    • (2001) Circulation , vol.104 , pp. 576-581
    • Dechend, R.1    Fiebeler, A.2    Park, J.K.3
  • 34
    • 0343990838 scopus 로고    scopus 로고
    • Effects of cholesterol reduction on BP response to mental stress in patients with high cholesterol
    • Sung BH, Izzo JL Jr, Wilson MF. Effects of cholesterol reduction on BP response to mental stress in patients with high cholesterol. Am J Hypertens. 1997;10:592-599.
    • (1997) Am J Hypertens , vol.10 , pp. 592-599
    • Sung, B.H.1    Izzo J.L., Jr.2    Wilson, M.F.3
  • 35
    • 0028945643 scopus 로고
    • Effects of pravastatin on cardiovascular reactivity to norepinephrine and angiotensin II in patients with hypercholesterolemia and systemic hypertension
    • Straznicky NE, Howes LG, Lam W, Louis WJ. Effects of pravastatin on cardiovascular reactivity to norepinephrine and angiotensin II in patients with hypercholesterolemia and systemic hypertension. Am J Cardiol. 1995;75:582-586.
    • (1995) Am J Cardiol , vol.75 , pp. 582-586
    • Straznicky, N.E.1    Howes, L.G.2    Lam, W.3    Louis, W.J.4
  • 36
    • 0033454062 scopus 로고    scopus 로고
    • Effect of the HMG-CoA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia
    • Glorioso N, Troffa C, Filigheddu F, et al. Effect of the HMG-CoA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia. Hypertension. 1999;34:1281-1286.
    • (1999) Hypertension , vol.34 , pp. 1281-1286
    • Glorioso, N.1    Troffa, C.2    Filigheddu, F.3
  • 37
    • 0030601262 scopus 로고    scopus 로고
    • Effect of fluvastatin on serum lipid levels in essential hypertension
    • Jarai Z, Kapocsi J, Farsang C, et al. Effect of fluvastatin on serum lipid levels in essential hypertension [in Hungarian]. Orv Hetil. 1996;137:1857-1859.
    • (1996) Orv Hetil , vol.137 , pp. 1857-1859
    • Jarai, Z.1    Kapocsi, J.2    Farsang, C.3
  • 38
    • 0032515570 scopus 로고    scopus 로고
    • Hypotensive effect of an inhibitor of cholesterol synthesis (fluvastatin): A pilot study
    • Abetel G, Poget PN, Bonnabry JP. Hypotensive effect of an inhibitor of cholesterol synthesis (fluvastatin): A pilot study [in French]. Schweiz Med Wochenschr. 1998;128:272-277.
    • (1998) Schweiz Med Wochenschr , vol.128 , pp. 272-277
    • Abetel, G.1    Poget, P.N.2    Bonnabry, J.P.3
  • 39
    • 0028895563 scopus 로고
    • Simvastatin treatment of hypercholesterolemia in patients with insulin dependent diabetes mellitus
    • Sartor G, Katzman P, Eizyk E, et al. Simvastatin treatment of hypercholesterolemia in patients with insulin dependent diabetes mellitus. Int J Clin Pharmacol Ther. 1995;33:3-6.
    • (1995) Int J Clin Pharmacol Ther , vol.33 , pp. 3-6
    • Sartor, G.1    Katzman, P.2    Eizyk, E.3
  • 40
    • 0025307034 scopus 로고
    • Simvastatin in the treatment of hypercholesterolemia in elderly patients
    • Antonicelli R, Onorato G, Pagelli P, et al. Simvastatin in the treatment of hypercholesterolemia in elderly patients. Clin Ther. 1990;12:165-171.
    • (1990) Clin Ther , vol.12 , pp. 165-171
    • Antonicelli, R.1    Onorato, G.2    Pagelli, P.3
  • 41
    • 0029088614 scopus 로고
    • Does lowering of cholesterol levels influence functional properties of large arteries?
    • Kool M, Lustermans F, Kragten H, et al. Does lowering of cholesterol levels influence functional properties of large arteries? Eur J Clin Pharmacol. 1995;48:217-223.
    • (1995) Eur J Clin Pharmacol , vol.48 , pp. 217-223
    • Kool, M.1    Lustermans, F.2    Kragten, H.3
  • 42
    • 0027393302 scopus 로고
    • Efficacy and tolerability of lovastatin in hypercholesterolemia in patients with systemic hypertension
    • D'Agostino RB, Kannel WB, Stepanians MN, D'Agostino LC. Efficacy and tolerability of lovastatin in hypercholesterolemia in patients with systemic hypertension. Am J Cardiol. 1993;71:82-87.
    • (1993) Am J Cardiol , vol.71 , pp. 82-87
    • D'Agostino, R.B.1    Kannel, W.B.2    Stepanians, M.N.3    D'Agostino, L.C.4
  • 43
    • 0033585499 scopus 로고    scopus 로고
    • Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: A randomized controlled trial
    • Davidson MH, Hauptman J, DiGirolamo M, et al. Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: A randomized controlled trial. JAMA. 1999;281:235-242.
    • (1999) JAMA , vol.281 , pp. 235-242
    • Davidson, M.H.1    Hauptman, J.2    DiGirolamo, M.3
  • 44
    • 0023139720 scopus 로고
    • Early and late effects of weight loss on lipoprotein metabolism in severe obesity
    • Rossner S, Bjorvell H. Early and late effects of weight loss on lipoprotein metabolism in severe obesity. Atherosclerosis. 1987;64:125-130.
    • (1987) Atherosclerosis , vol.64 , pp. 125-130
    • Rossner, S.1    Bjorvell, H.2
  • 45
    • 0029092064 scopus 로고
    • Simvastatin: A reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia
    • Plosker GL, McTavish D. Simvastatin: A reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia. Drugs. 1995;50:334-363.
    • (1995) Drugs , vol.50 , pp. 334-363
    • Plosker, G.L.1    McTavish, D.2
  • 46
    • 84992791486 scopus 로고    scopus 로고
    • A randomized multicenter trial comparing the efficacy of simvastatin and fluvastatin
    • Illingworth DR, Stein EA, Knopp RH, et al. A randomized multicenter trial comparing the efficacy of simvastatin and fluvastatin. J Cardiovasc Pharmacol Ther. 1996;1:23-30.
    • (1996) J Cardiovasc Pharmacol Ther , vol.1 , pp. 23-30
    • Illingworth, D.R.1    Stein, E.A.2    Knopp, R.H.3
  • 47
    • 0028096810 scopus 로고
    • A review of clinical trials comparing HMG-CoA reductase inhibitors
    • Illingworth DR, Tobert JA. A review of clinical trials comparing HMG-CoA reductase inhibitors. Clin Ther. 1994;16:366-385.
    • (1994) Clin Ther , vol.16 , pp. 366-385
    • Illingworth, D.R.1    Tobert, J.A.2
  • 48
    • 0028245981 scopus 로고
    • Defined daily doses in relation to hypolipidaemic efficacy of lovastatin, pravastin, and simvastatin
    • Illingworth DR, Erkelens DW, Keller U, et al. Defined daily doses in relation to hypolipidaemic efficacy of lovastatin, pravastin, and simvastatin. Lancet. 1994;343:1554-1555.
    • (1994) Lancet , vol.343 , pp. 1554-1555
    • Illingworth, D.R.1    Erkelens, D.W.2    Keller, U.3
  • 49
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 50
    • 0029101267 scopus 로고
    • Reducing the risk of coronary events: Evidence from the Scandinavian Simvastatin Survival Study (4S)
    • Kjekshus J, Pedersen TR. Reducing the risk of coronary events: Evidence from the Scandinavian Simvastatin Survival Study (4S). Am J Cardiol. 1995;76:64C-68C.
    • (1995) Am J Cardiol , vol.76
    • Kjekshus, J.1    Pedersen, T.R.2
  • 51
    • 0029004377 scopus 로고
    • Baseline serum cholesterol and treatment effect in the Scandinavian Simvastatin Survival Study (4S)
    • Baseline serum cholesterol and treatment effect in the Scandinavian Simvastatin Survival Study (4S). Lancet. 1995;345:1274-1275.
    • (1995) Lancet , vol.345 , pp. 1274-1275


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.