In vitro and in vivo activities of OX40 (CD134)-IgG fusion protein isoforms with different levels of immune-effector functions

Journal of Leukocyte Biology

Volumn 72, Issue 3, 2002, Pages 522-529

  Taylor, Liz ^a   Bachler, Marcus ^b   Duncan, Imogen ^a   Keen, Simon ^a   Fallon, Rosie ^a   Mair, Catherine ^a   McDonald, Thomas T ^b   Schwarz, Herbert ^a  

^a Cantab Pharmaceuticals Ltd   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

ADCC; Colitis; Complement lysis

Indexed keywords

CD134 ANTIGEN; CYTOKINE; GLUTAMINE; HYBRID PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4; LEUCINE; RECOMBINANT PROTEIN;

ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIGEN PRESENTING CELL; ARTICLE; CELL DEATH; CELL PROLIFERATION; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; EFFECTOR CELL; ENDOTHELIUM CELL; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IMMUNOREGULATION; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD27; ANTIGENS, SURFACE; COLITIS; CYTOKINES; DRUG DESIGN; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN G; IMMUNOTHERAPY; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR MIMICRY; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, OX40; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

ANIMALIA;

EID: 0036746073     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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