Lactose modifications enhance its drug performance in the novel multiple dose Taifun® DPI

European Journal of Pharmaceutical Sciences

Volumn 16, Issue 4-5, 2002, Pages 313-321

  Harjunen, Päivi ^a   Lehto, Vesa Pekka ^b,c   Martimo, Krista ^a   Suihko, Eero ^a   Lankinen, Tapio ^c   Paronen, Petteri ^a   Järvinen, Kristiina ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c Focus Inhalation Oy   (Finland)

Author keywords

Budesonide; Inhalation powder; Lactose; Multiple dose DPI; Spray drying; Taifun

Indexed keywords

AEROSOLS; CRYSTALLIZATION; DRUG DOSAGE; POWDERS;

INHALERS;

DRUG PRODUCTS;

ALPHA LACTOSE; BUDESONIDE; CRYSTALLIN; DRUG CARRIER; FLOWLAC; LACTOSE; TAIFUN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLIZATION; DRUG FORMULATION; DRUG STORAGE; DRY POWDER; LUNG DEPOSIT; POWDER; POWDER INHALER; PRIORITY JOURNAL; RESERVOIR; THEORETICAL STUDY;

BUDESONIDE; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; DRUG STORAGE; LACTOSE; METERED DOSE INHALERS; MODELS, BIOLOGICAL; PARTICLE SIZE; POWDERS;

EID: 0036741491     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00126-4     Document Type: Article

References (26)

1. Angberg M., Nyström C., Castensson S. Evaluation of heat-conduction microcalorimetry in pharmaceutical stability studies. V. A new approach for continuous measurements in abundant water vapour. Int. J. Pharm. 81:1992;153-167.
2. Angberg M., Nyström C., Castensson S. Evaluation of heat-conduction microcalorimetry in pharmaceutical stability studies. VI. Continuous monitoring of the interaction of water vapour with powders and powder mixtures at various relative humidities. Int. J. Pharm. 83:1992;11-23.
3. Borgström L., Newman S. Total and regional lung deposition of terbutaline sulphate via a pressurised MDI or via Turbuhaler. Int. J. Pharm. 97:1993;47-53.
4. Braun M.A., Oschmann P., Schmidt P.C. Influence of excipients and storage humidity on the deposition of disodium cromoglycate (DSCG) in the Twin Impinger. Int. J. Pharm. 135:1996;53-62.
5. Briggner L.E., Buckton G., Bystrom K., Darcy P. The use of isothermal microcalorimetry in the study of changes in crystallinity induced during the processing of powders. Int. J. Pharm. 105:1994;125-135.
6. Buckton G., Darcy P. Water mobility in amorphous lactose below and close to the glass transition temperature. Int. J. Pharm. 136:1996;141-146.
7. Iida K., Hayakawa Y., Okamoto H., Danjo K., Leuenberger H. Evaluation of flow properties of dry powder inhalation of salbutamol sulphate with lactose carrier. Chem. Pharm. Bull. 49:2001;1326-1330.
8. Karhu M., Kuikka J., Kauppinen T., Bergström K., Vidgren M. Pulmonary deposition of lactose carriers used in inhalation powders. Int. J. Pharm. 196:2000;95-103.
9. Kawashima Y., Serigano T., Hino T., Yamamoto H., Takeuchi H. Effect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrate. Int. J. Pharm. 172:1998;179-188.
10. Larhrib H., Zeng X.M., Martin G.P., Marriott C., Pritchard J. The use of different grades of lactose as a carrier for aerosolised salbutamol sulphate. Int. J. Pharm. 191:1999;1-14.
11. Lankinen, T., 1999. A method for making a pharmaceutical formulation. Patent WO 99/34778.
12. Maggi L., Bruni R., Conte U. Influence of the moisture on the performance of a new dry powder inhaler. Int. J. Pharm. 177:1999;83-91.
13. Naini V., Byron P.R., Phillips E.M. Physicochemical stability of crystalline sugars and their spray-dried forms: Dependence upon relative humidity and suitability for use in powder inhalers. Drug Dev. Ind. Pharm. 24:1998;895-909.
14. Pitcairn G.R., Lankinen T., Vankila E., Newman S.P. Lung deposition of salbutamol from the Leiras metered dose powder inhaler. J. Aerosol Med. 3:1995;307-311.
15. Pitcairn G.R., Lankinen T., Seppälä O.-P., Newman S.P. Pulmonary drug delivery from the Taifun dry powder inhaler is relatively independent of the patient's inspiratory effort. J. Aerosol Med. 2:2000;97-104.
16. Prime D., Atkins P.J., Slater A., Sumby B. Review of dry powder inhalers. Adv. Drug. Deliv. Rev. 26:1997;51-58.
17. Podczeck F. The relationship between physical properties of lactose monohydrate and the aerodynamic behaviour of adhered drug particles. Int. J. Pharm. 160:1998;119-130.
18. Staniforth J.N. Pre-formulation aspects of dry powder aerosols. Respiratory Drug Delivery V. The Fifth in a Series of International Symposia, April 28-May 2, 1996, Phoenix, AZ. 1996;Interpharm Press Buffalo Grove, IL.
19. Stubberud L., Forbes R.T. The use of gravimetry for the study of the effect of additives on the moisture-induced recrystallisation of amorphous lactose. Int. J. Pharm. 163:1998;145-156.
20. Tee S.K., Mariott C., Zeng X.M., Martin G.P. The use of different sugars as fine and coarse carriers for aerosolised salbutamol sulphate. Int. J. Pharm. 208:2000;111-123.
21. Zeng X.M., Martin G.P., Marriott C. Particulate Interactions in Dry Powder Formulations For Inhalation. 2001;Taylor & Francis London.
22. Zeng X.M., Martin G.P., Marriott C., Pritchard J. The effects of carrier size and morphology on the dispersion of salbutamol sulphate after aerosolization at different flow rates. J. Pharm. Pharmacol. 52:2000;1211-1221.
23. Zeng X.M., Martin G.P., Marriott C., Pritchard J. The influence of carrier morphology on drug delivery by dry powder inhalers. Int. J. Pharm. 200:2000;93-106.
24. Zeng X.M., Martin G.P., Marriott C., Pritchard J. Lactose as a carrier in dry powder formulations: The influence of surface characteristics on drug delivery. J. Pharm. Sci. 9:2001;1424-1434.
25. Zeng X.M., Martin G.P., Tee S.K., Ghoush A.A., Marriott C. Effects of particle size and adding sequence of fine lactose on the deposition of salbutamol sulphate from a dry powder formulation. Int. J. Pharm. 182:1999;133-144.
26. Zeng X.M., Martin G.P., Tee S.-K., Marriott C. The role of fine particle lactose on the dispersion and deaggregation of salbutamol sulphate in an air stream in vitro. Int. J. Pharm. 176:1998;99-110.