Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia

Journal of Endocrinology

Volumn 174, Issue 3, 2002, Pages 447-454

  Suarez C ^a   Garcia Tornadu I ^a   Khalil, W ^a   Becu Villalobos, D ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLSTILBESTROL; ESTROGEN; GROWTH HORMONE; LEPTIN; PRASTERONE; PROLACTIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; BREAST TUMOR; CANCER INHIBITION; COLON TUMOR; CONTROLLED STUDY; DRUG IMPLANT; FEMALE; GROWTH HORMONE BLOOD LEVEL; HORMONE ACTION; HYPERPLASIA; HYPERPROLACTINEMIA; HYPOPHYSIS DISEASE; LIVER TUMOR; LUNG TUMOR; NONHUMAN; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PROSTATE TUMOR; RADIOIMMUNOASSAY; RAT; RAT STRAIN; SKIN TUMOR; WEIGHT REDUCTION;

ANIMALS; DEHYDROEPIANDROSTERONE; DIETHYLSTILBESTROL; FEMALE; GROWTH HORMONE; HYPERPLASIA; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MODELS, ANIMAL; ORGAN SIZE; PITUITARY GLAND; PROLACTIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036741447     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1740447     Document Type: Article

References (55)

1. Arimura A, Smith W & Schally A 1976 Blockade of the stress-induced decrease in blood GH by antisomatostatin serum in rats. Endocrinology 98 540-543.
2. Arlt W, Callies F & Allolio B 2000 DHEA replacement in women with adrenal insufficiency: pharmacokinetics, bioconversion and clinical effects on well-being, sexuality and cognition. Endocrine Research 26 505-511.
3. Boccuzzi G, Aragno M, Brignardello E, Tamagno E, Conti G, Di Monaco M, Racca S, Danni O & Di Carlo F 1992 Opposite effects of dehydroepiandrosterone on the growth of 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas. Anticancer Research 12 1479-1483.
4. Boccuzzi G, Di Monaco M, Brignardello E, Leonardi L, Gatto V, Pizzini A & Gallo M 1993 Dehydroepiandrosterone antiestrogenic action through androgen receptor in MCF-7 human breast cancer cell line. Anticancer Research 13 2267-2272.
5. Borski RJ, Tsai W, DeMott-Friberg R & Barkan AL 1996 Regulation of somatic growth and the somatotropic axis by gonadal steroids: primary effect on insulin-like growth factor I gene expression and secretion. Endocrinology 137 3253-3259.
6. Brann DW, De Sevilla L, Zamorano PL & Mahesh VB 1999 Regulation of leptin gene expression and secretion by steroid hormones. Steroids 64 659-663.
7. Bray MJ, Vick TM, Shah N, Anderson SM, Rice LWIA, Evans RM & Veldhuis JD 2001 Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin's dose-dependent inhibition of fasting growth hormone secretion. Journal of Clinical Endocrinology and Metabolism 86 3143-3149.
8. Cleary M 1991 The antiobesity effects of DHEA in rats. Proceedings of the Society for Experimental Biology and Medicine 196 8-16.
9. De Nicola AF, von Lawzewitsch I, Kaplan SE & Libertun C 1978 Biochemical and ultrastructural studies on estrogen-induced pituitary tumors in F344 rats. Journal of the National Cancer Institute 61 753-763.
10. Diaz-Torga GS, Gonzalez Iglesias A, Achaval-Zaia R, Libertun C & Becu-Villalobos D 1998 Angiotensin II induced calcium mobilization and prolactin release in normal and hyperplastic pituitary cells. American Journal of Physiology 274 E534-E540.
11. Diaz-Torga G, Feierstein C, Libertun C, Gelman D, Kelly MA, Low MJ, Rubinstein M & Becu-Villalobos D 2002 Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice. Endocrinology 143 1270-1279.
12. Ebeling P & Koivisto VA 1994 Physiological importance of dehydroepiandrosterone. Lancet 343 1479-1481.
13. Frye CA & Lacey EH 1999 The neurosteroids DHEA and DHEAS may influence cognitive performance by altering affective state. Physiology and Behavior 66 85-92.
14. Gansler TS, Muller S & Cleary MP 1985 Chronic administration of dehydroepiandrosterone reduces pancreatic beta-cell hyperplasia and hyperinsulinemia in genetically obese Zucker rats. Proceedings of the Society for Experimental Biology and Medicine 180 155-162.
15. Gatto V, Aragno M, Gallo M, Tamagno E, Martini A, Dimonaco M, Brignardello E & Boccuzzi G 1998 Dehydroepiandrosterone inhibits the growth of DMBA-induced rat mammary carcinoma via the androgen receptor. Oncology Reports 5 241-243.
16. Gonzalez Iglesias A, Diaz-Torga G, Piroli G, Achaval-Zaia R, De Nicola AF, Libertun C & Becu-Villalobos D 2000 Bromocriptine restores angiotensin II response in pituitary hyperplasia. Molecular and Cellular Endocrinology 165 67-74.
17. Hertz P, Silbermann LE, Even L & Hochberg Z 1989 Effects of sex steroid on the response of cultured rat pituitary cells to growth hormone-releasing hormone and somatostatin. Endocrinology 125 581-585.
18. Hinson JP & Raven PW 1999 DHEA deficiency syndrome: a new term for old age? Journal of Endocrinology 163 1-5.
19. Hu Y, Cardounel A, Gursoy E, Anderson P & Kalimi M 2000 Anti-stress effects of dehydroepiandrosterone: protection of rats against repeated immobilization stress-induced weight loss, glucocorticoid receptor production, and lipid peroxidation. Biochemical Pharmacology 59 753-762.
20. Jarrar D, Wang P, Cioffi WG, Bland KI & Chaudry IH 2000 Mechanisms of the salutary effects of dehydroepiandrosterone after trauma-hemorrhage: direct or indirect effects on cardiac and hepatocellular functions? Archives of Surgery 135 416-423.
21. Knudsen JF, Costoff A & Mahesh VB 1975 Dehydroepiandrosterone induced polycystic ovaries and acyclicity in the rat. Fertility and Sterility 26 807-817.
22. Kroboth PD, Salek FS, Pittenger AL, Fabian TJ & Frye RF 1999 DHEA and DHEA-S: a review. Journal of Clinical Pharmacology 39 327-348.
23. Labrie F, Diasmond P, Cusan L, Gomez JL, Belanger A & Candas B 1997 Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. Journal of Clinical Endocrinology and Metabolism 82 3498-3505.
24. Lacau-Mengido IM, Mejía M, Diaz-Torga G, Gonzalez Iglesias A, Formía N, Libertun C & Becu-Villalobos D 2000 Endocrine studies in ivermectin-treated heifers from birth to puberty. Journal of Animal Science 78 1-8.
25. Ladriere L, Laghmich A, Malaisse-Lagae F & Malaisse WJ 1997 Effect of dehydroepiandrosterone in hereditarily diabetic rats. Cellular and Biochemical Function 15 287-292.
26. Lardy H, Partridge B, Kneer N & Wei Y 1995 Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. PNAS 92 6617-6619.
27. Li K, Foo T & Adams JB 1978 Products of dehydroepiandrosterone metabolism by human mammary tumors and their influence on estradiol receptor binding. Steroids 31 113-127.
28. Maggiolini M, Donzé O, Jeannin E, Andò S & Didier P 1999 Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor α. Cancer Research 59 4864-4869.
29. McIntosh M, Bao H & Lee C 1999 Opposing actions of dehydroepiandrosterone and corticosterone in rats. Proceedings of the Society for Experimental Biology and Medicine 221 198-206.
30. Morales A, Nolan J, Nelson J & Yen S 1994 Effects of replacement dose of DHEA in men and women of advancing age. Journal of Clinical Endocrinology and Metabolism 78 1360-1367.
31. Müller E, Locatelli V & Cocchi D 1999 Neuroendocrine control of growth hormone secretion. Physiological Reviews 79 511-607.
32. Nippoldt TB & Nair KS 1998 Is there a case for DHEA replacement? Baillieres Clinical and Endocrinological Metabolism 12 507-520.
33. Nyce JW, Magee PN, Hard GC & Schwartz AG 1984 Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehydroepiandrosterone. Carcinogenesis 5 57-62.
34. Paolisso G, Rizzo MR, Mone CM, Tagliamonte MR, Gambardella A, Riondino M, Carella C, Varricchio M & D'Onofrio F 2001 Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects. Clinical Endocrinology 48 291-297.
35. Parente JA Jr & Berdanier CD 1993 Drugs that suppress hepatic fat synthesis in starved-refed BHE/cdb rats also have an effect on muscle protein synthesis. Proceedings of the Society for Experimental Biology and Medicine 204 172-179.
36. Pashko LL, Hard GC, Rovito KJ, Williams JR, Sobel EL & Schwartz AG 1985 Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin papillomas and carcinomas by dehydroepiandrosterone and 3-beta-methylandrost-5-en-17-one in mice. Cancer Research 45 164-166.
37. Pineiro V, Casabiell X, Peino R, Lage M, Camina JP, Menendez C, Baltar J, Dieguez C & Casanueva F 1999 Dihydrotestosterone, stanazolol, androstenedione and dehydroepiandrosterone sulphate inhibit leptin secretion in female but not in male samples of omental adipose tissue in vitro: lack of effect of testosterone. Journal of Endocrinology 160 425-432.
38. Piroli G, Grillo CA, Ferrini MG, Lux-Lantos V & De Nicola AF 1996 Antagonism by progesterone of diethylstilbestrol-induced pituitary tumorigenesis in Fischer 344 rats: effects on sex steroid receptors and tyrosine hydroxylase mRNA. Neuroendocrinology 63 530-539.
39. Poortman J, Prenen JAC, Schwarz F & Thijssen JHH 1975 Interaction of delta-5-androstene-3 beta, 17 beta-diol with estradiol and dihydrotestosterone receptors in human myometrial and mammary cancer tissue. Journal of Clinical Endocrinology and Metabolism 40 373-379.
40. Rao KVN, Johnson WD, Bosland MC, Lubet RA, Steele VE, Kelloff GJ & McCormick DL 1999 Chemoprevention of rat prostate carcinogenesis by early and delayed administration of dehydroepiandrosterone. Cancer Research 59 3084-3089.
41. Rao MS, Subbarao V, Yeldandi AV & Reddy JK 1992 Hepatocarcinogenicity of dehydroepiandrosterone in the rat. Cancer Research 52 2977-2979.
42. Richards RJ, Porter JR & Svec F 2000 Serum leptin, lipids, free fatty acids, and fat pads in long-term dehydroepiandrosterone-treated Zucker rats. Proceedings of the Society for Experimental Biology and Medicine 223 258-262.
43. Rose K, Allan A, Gauldie S, Stapleton G, Lorraine D, Dott K, Martin C, Wang L, Hedlund E, Seckl JR, Gustafsson J-Å & Lathe R 2001 Neurosteroid hydroxylase CYP7B. Vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation. Journal of Biological Chemistry 276 23937-23944.
44. Sarkar DK, Gottschall PE & Meites J 1982 Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors. Science 218 684-686.
45. Schiffelholz T, Holsboer F & Lancel M 2000 High doses of systemic DHEA-sulfate do not affect sleep structure and elicit moderate changes in non-REM sleep EEG in rats. Physiology and Behavior 69 399-404.
46. Schwartz AG & Tannen RH 1981 Inhibition of 7,12-dimethylbenz-[a]anthracene- and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone. Carcinogenesis 2 1335-1337.
47. Schwartz AG, Fairman DK, Polansky M, Lewbart ML & Pashko LL 1989 Inhibition of 7,12-dimethylbenz[a]anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin papilloma formation in mice by dehydroepiandrosterone and two synthetic analogs. Carcinogenesis 10 1809-1813.
48. Shepherd A & Cleary MP 1984 Metabolic alterations after dehydroepiandrosterone treatment in Zucker rats. American Journal of Physiology. Endocrinology and Metabolism 246 E123-E128.
49. Shulman DI, Sweetland M, Duckett G & Root AW 1987 Effect of estrogen on the growth hormone secretory response to GH-releasing factor in the castrate adult female rat in vivo. Endocrinology 120 1047-1051.
50. Simard J, Vincent A, Duchesne R & Labrie F 1988 Full oestrogenic activity of C19-delta 5 adrenal steroids in rat pituitary lactotrophs and somatotrophs. Molecular and Cellular Endocrinology 55 233-242.
51. Sourla A, Martel C, Labrie C & Labrie F 1998 Almost exclusive androgenic action of dehydroepiandosterone in the rat mammary gland. Endocrinology 139 753-764.
52. Svec F & Porter J 1998 The actions of exogenous dehydroepiandrosterone in experimental animals and humans. Proceedings of the Society for Experimental Biology and Medicine 218 174-191.
53. Ward CW, Costoff A & Mahesh VB 1978 The induction of polycystic ovaries in mature cycling rats by the administration of dehydroepiandrosterone (DHEA). Biology of Reproduction 18 614-623.
54. Wolf OT & Kirschbaum C 1999 Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans. Brain Research Reviews 30 264-288.
55. Yang JY, Schwartz AG & Henderson EE 1994 Inhibition of 3′ azido-3′ deoxythymidine-resistant HIV-1 infection by dehydroepiandrosterone in vitro. Biochemical and Biophysical Research Communications 201 1424-1432f.