Can pentoxifylline prevent renal disease?

Renal Failure

Volumn 20, Issue 3, 1998, Pages 437-440

  Wardle, E Nigel ^a  

^a NONE   (United Kingdom)

Author keywords

Collagen formation; Cyclic AMP; Diabetic nephropathy; Free radical scavenger; Mesangial cells; Pentoxifylline; Phosphodiesterase inhibitor; Proteinuria

Indexed keywords

BETA 2 MICROGLOBULIN; COLLAGEN; CYCLIC AMP; CYTOKINE; GAMMA INTERFERON; GRANZYME B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR; SCAVENGER; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

CELL PROLIFERATION; CHRONIC GLOMERULONEPHRITIS; DIABETES MELLITUS; DIABETIC NEPHROPATHY; GLOMERULUS FILTRATION RATE; HUMAN; INTERSTITIAL NEPHRITIS; LEUKOCYTOCLASTIC VASCULITIS; MACROPHAGE; MESANGIUM CELL; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; POLYARTERITIS NODOSA; PRIORITY JOURNAL; REVIEW; THROMBOCYTE AGGREGATION;

EID: 0031901099     PISSN: 0886022X     EISSN: None     Source Type: Journal    
DOI: 10.3109/08860229809045132     Document Type: Review

References (33)

1. Hammerschmidt DE, Kotasch D, McCarty T: Pentoxifylline inhibits granulocyte and platelet function including priming by platelet activating factor. J Lab Clin Med 112:254-262, 1988.
2. Currie MS, Rao KNK, Padmanabhan J, Jones A, Crawford J, Cohen HJ: Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation and superoxide production. J Leukocyte Biology 47:244-250, 1990.
3. Carletto A, Biasi D, Bambara LM, Caramaschi P, et al.: Studies of skin window exudate human neutrophils: Increased resistance to pentoxifylline of respiratory burst in promed cells. Inflammation 21:191-203, 1997.
4. Rao KMK, Currie MS, McCachren SS, Cohen HJ: Pentoxifylline and other methylxanthines inhibit interleukin 2 receptor expression in human lymphocytes. Cell Immunology 135:314-325, 1991.
5. Dong RP, Umezawa Y, Ikushima H, Munakata Y, Schlossman SF, Morimoto C: Different regulatory effects of pentoxifylline on human T cell activation pathways. J Clin Immunol 17:247-52, 1997.
6. Hoskin D, Wi Phu T, Makrigiannis AP: Pentoxifylline inhibits granzyme B and perform expression following T lymphocyte activation by antiCD3 antibody. Int J Immunopharmacology 18: 623-631, 1996.
7. Bruynzeel I, van der Raaij LM, Willemze R, Stoof TJ: Pentoxifylline inhibits human T cell adhesion to dermal endothelial cells. Arch Dermatol Res 289:189-191, 1997.
8. Schandene L, Vandenbusche P, Crusiaux A, Alegre ML, Abramowicz D, Dupont E, Content J, Goldman N: Differential effect of pentoxifylline on the production of tumour necrosis factor and I1-6 by monocytes and T cells. Immunology 76:30-34, 1992.
9. Hecht M, Muller M, Lohmann-Matthes NL, Emmendorfer A. In vitro and in vivo effects of pentoxifylline on macrophages and lymphocytes derived from autoimmune MRL lpr/lpr mice. J Leukocyte Biology 57:242-249, 1995.
10. Neuner P, Klosner G, Pourmojib M, Knobler R, Schwarz T. Pentoxifylline in vivo and in vitro down-regulates the expression of ICAM-1 in monocytes. Immunology 90:435-439, 1997.
11. Lidington E, Nohammer C, Dominguez M, Ferry B, Rose NL: Inhibition of the trans-endothelial migration of human lymphocytes but not monocytes by phosphodiesterase inhibition. Clin Exp Immunology 104:66-71, 1996.
12. Wardle EN: Neutralizing inflammatory cytokines in nephritis. Nephron 69:223-227, 1995.
13. Moller DR, Wysocka M, Greenlee BM, Ma X, Wahl L, Trinchieri G, Karp CL: Inhibition of human interleukin 12 production by pentoxifylline. Immunology 91:197-203, 1997.
14. Trichiere G: Interleukin 12,a proinflammatory cytokine with immuno-regulatory functions. Ann Review Immunol 13: 251, 1995.
15. Ma X, Chow JM, Gri G, Carra G, Gerosa F, Wolf SF, Dzialo R, Trinchieri G: The interleukin 12 p40 gene promoter is primed by interferon-gamma in monocytic cells. J Exp Med 183: 147, 1996.
16. Rieckmann P, Weber F, Gunther A, Martin S, Bitseh A, et al: Pentoxifylline a phosphodiesterase inhibitor, induces immune deviation in patients with multiple sclerosis. J Neuro Immunology 64(2):193-200, 1996.
17. Kiely PD, Gillespie KM, Oliveira: Oxypentifylline inhibits TNFa mRNA transcription and protects against arthritis in mercuric chloride treated Brown Norway rats. Europ J Immunology 25:2899-2906, 1995.
18. Tsai T-J, Lin P-H, Chang C-C, Chen Y-M, Chen C-F, Ko F-N, Teng C-M: Vasodilator agents modulate rat glomerular mesangial cell growth and collagen synthesis. Nephron 70:91-99, 1995.
19. Schiller AD, Petrica L, Gluhovschi GH, Giorgita A, Dan H, Transafirescu V: Effect of pentoxifylline on proteinuria and GFR in patients with chronic glomerulonephritis. Nephrol Dial Transplant 11:A97, 1996.
20. Calderon MJ, Landa N, Aguirre A, Diaz-Perez JL: Successful treatment of cutaneous polyarteritis nodosa with pentoxifylline. British J Dermatol 128:706-708, 1993.
21. Nurnberg W, Grabbe J, Czarnetski E: Synergistic effects of pentoxifylline and dapsone in leucocytoclastic vasculitis. Lancet 343, 491,1994.
22. Furukawa S, Matsubara T, Umezawa Y, et al: Pentoxifylline and intravenous gamma globulin therapy for acute Kawasaki disease. Europ J Pediatrics 153:663-667, 1994.
23. Campbell RK: Clinical update on pentoxifylline therapy for diabetes induced peripheral vascular disease. Annals Pharmacotherapy 27:1099-1105, 1993.
24. Sonkin PL, Kelly LW, Sinclair SF, Hatchell DL: Pentoxifylline increases retinal capillary blood flow velocity in patients with diabetes. Archives Ophthal 111:1647-1652, 1993.
25. Ohdama S, Takano S, Ohashi M, Miyake S, Aoki N: Pentoxifylline prevents tumor necrosis factor induced suppression of endothelial cell surface thrombomodulin. Thrombosis Res 62:745-755, 1991.
26. Guerrero-Romero F, Rodriguez-Moran M, Paniagua-Sierra JR, Garcia-Bulnes G, Salas-Ramirez M, Amato D: Pentoxifylline reduces proteinuria in non-insulin dependent diabetes patients. Clin Nephrology 43:116-121, 1995.
27. Murrel GA, Francis M J, Bromley L: Modulation of fibroblast proliferation by oxygen free radicals. Biochem J 265:659-665, 1990.
28. Poli G, Panola M: Oxidative dainage and fibrogenesis. Free Radical Biol Med 22: 287-305, 1997.
29. Franzini B, Sellak H, Marquetty C, Babin-Chevaye C, Hakim J, Pasquier C: Inhibition of human neutrophil binding to hydrogen peroxide treated andothelial cells by cAMP and hydroxyl radical scavengers. Free Rad Biol Med 21: 15-23, 1996.
30. Fine A, Poliks CF, Donahue LP, Small BD, Goldstein RH: Differential effect of prostaglandin E2 on TGFbeta and insulin induced collagen formation in lung fibroblasts. J Biol Chem 264:16988-16996, 1989.
31. Windmeier C, Gressner AM: Effect of pentoxifylline on the fibrogenic functions of cultured rat liver fat storing cells and myofibroblasts. Biochem Pharmacol 51:577-584, 1996.
32. Peterson TC: Inhibition of fibroproliferation by pentoxrfylline. Biochem Pharmacol 52:597-602, 1996.
33. Reichert LJM, Koene R, Wetzels J: Urinary excretion of β2-microglobulin predicts outcome in patients with idiopathic membranous nephropathy. J Amer Soc Nephrology 6:1666-1669, 1995.