2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2

Toxicological Sciences

Volumn 69, Issue 1, 2002, Pages 117-124

  Laiosa, Michael D ^a   Lai, Zhi Wei ^a   Thurmond, T Scott ^b   Fiore, Nancy C ^a   DeRossi, Charles ^c   Holdener, Bernadette C ^c   Gasiewicz, Thomas A ^b   Silverstone, Allen E ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

AHR; ARNT2; bHLH PAS; Bone marrow; Dioxin; Lymphocyte development; TCDD; Thymus

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CARRIER PROTEIN; DIOXIN; HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARNT2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL NUCLEUS; CHIMERA; CHROMOSOME 7; CHROMOSOME ABERRATION; CONTROLLED STUDY; DIMERIZATION; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GENE LOSS; HEMATOPOIESIS; IMMUNITY; LIVER CELL; LYMPHOCYTE SUBPOPULATION; MOUSE; MOUSE STRAIN; NONHUMAN; RECEPTOR BINDING; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; SEQUENCE HOMOLOGY; STEM CELL; THYMOCYTE; THYMUS; THYMUS ATROPHY;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; ATROPHY; CELL COUNT; CELL SEPARATION; CHIMERA; ENVIRONMENTAL POLLUTANTS; FLOW CYTOMETRY; HEMATOPOIETIC SYSTEM; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRACHLORODIBENZODIOXIN; THYMUS GLAND; TRANSCRIPTION FACTORS;

ANIMALIA; VERTEBRATA;

EID: 0036738723     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.1.117     Document Type: Article

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