Inhibition of the mitochondrial respiratory chain by alanine in rat cerebral cortex

Metabolic Brain Disease

Volumn 17, Issue 3, 2002, Pages 123-130

  Rech, Virginia C ^a   Feksa, Luciane R ^a   Dutra Filho, Carlos S ^a   Wyse, Angela T S ^a   Wajner, Moacir ^a   Wannmacher, Clovis M D ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Alanine; Respiratory chain; Succinate dehydrogenase

Indexed keywords

ALANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; MITOCHONDRIAL RESPIRATION; NONHUMAN; PROTEIN CONTENT; RAT; RESPIRATORY CHAIN; SUPPLEMENTATION;

ALANINE; ANIMALS; CEREBRAL CORTEX; ELECTRON TRANSPORT; ENERGY METABOLISM; MITOCHONDRIA; NAD; NERVE TISSUE PROTEINS; RATS; RATS, WISTAR; SUCCINATE DEHYDROGENASE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0036734309     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019973719399     Document Type: Article

References (30)

1. Oxygen activation and the conservation of energy in cell respiration
2. Control of glutamate metabolism. The effect of pyruvate
3. The effect of age upon the entry of some amino acids into de brain and its incorporation into cerebral protein
4. Energetics in the pathogenesis of neurodegenerative diseases
5. An analysis of the role of coenzyme Q in free radical generation and as an anti-oxidant
6. Recent advances on the mechanism of the active-non-active transition of succinate dehydrogenase
7. Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: Relevance to Parkinson's disease
8. Disorders related to mitochondrial membranes: Pathology of the respiratory chain and neurodegeneration
9. Mitochondrial function a determinant of recovery or death in cell response to injury
10. Cerebral alanine transport and alanine aminotransferase reaction: Alanine as a source of glutamate
11. Differencial investigation of the capacity of succinate oxidation in human skeletal muscle
12. The effect of opposing effectors on activation level of succinate dehydrogenase: Equilibrium and kinetic studies
13. +) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles
14. Protein measurement with the Folin phenol reagent
15. Anabolic effect of human hormone: Management of inherited disorders of catabolic pathways
16. Neurotoxicity of glutamate uptake inhibition in vivo: Correlation with succinate dehydrogenase activity and prevention by energy substrates
17. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
18. +) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase
19. Human complex I deficiency: Clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect
20. Biosynthesis of the nutritionally nonessential amino acids
21. Biochemical and molecular investigations in respiratory chain deficiencies
22. 2+ release: An intimate connection
23. Mitochondrial involvement in Parkinson's disease. Huntington's disease, hereditary spastic paraplegia an Friedreich's ataxia
24. Mitochondrial complex I deficiency in Parkinson's disease
25. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity
26. Localization of endogenous ATPases at the nerve terminal
27. NADH and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation
28. Neuropathological aspects of cytochrome c oxidase deficiency
29. Mitochondrial diseases in man and mouse
30. +-ATPase activity in experimental phenylketonuria