Localization of the induced metallothionein and DNA damage in rat kidney after gold injection

Journal of Histochemistry and Cytochemistry

Volumn 50, Issue 9, 2002, Pages 1263-1271

  Saito, Shigeru ^a   Kurasaki, Masaaki ^a   Hosokawa, Toshiyuki ^a   Okabe, Masashi ^a   Saito, Takeshi ^a   Fujii, Yukiko ^a   Nagashima, Kazuo ^a   Yoshida, Katsumi ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Copper; Cu MT; DNA damage; Gold; Kidney; Metallothionein; TUNEL

Indexed keywords

BINDING PROTEIN; COPPER; GOLD; METALLOTHIONEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL ORGANELLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DNA DAMAGE; KIDNEY CORTEX; KIDNEY MEDULLA; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

ANIMALIA;

EID: 0036733584     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540205000913     Document Type: Article

References (40)

1. Histochemical demonstration of heavy metals with the sulfide-silver method. A methodological study
2. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene
3. Gene amplification of the Menkes (MNK; ATP7A) P-type Atpase gene of CHO cells is associated with copper resistance and enhanced copper efflux
4. DNA-scission activities of ascorbate in the presence of metal chelates
5. Metallothionein and apoptosis in the toxic milk mutant mouse
6. Histochemical and immunocytochemical evaluation of copper and metallothionein in the liver and kidney of copper-loaded rats
7. Histochemical demonstration of copper in LEC rat liver
8. Identification of programmed cell death in site via specific labeling of nuclear DNA fragmentation
9. Pathobiology of copper-induced injury in Bedlington terriers: Ultrastructural and microanalytical studies
10. Immunohistochemical detection of metallothionein
11. Evolution, structure and chemical activity of class I metallothioneins: An overview
12. Histochemical detection of zinc and copper in various parts of the central nervous system
13. Copper metabolism in the kidney of rats administered copper and coppermetallothionein
14. Histochemical characterization of silver-induced metallothionein in kidney of rat
15. Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease
16. Subchronic treatment of rats with aurothioglucose: Effects on plasma, hepatic, renal and urinary zinc, copper and metallothionein
17. Isolation of a partial candidate gene for Menkes disease by positional cloning
18. Copper-binding metallothionein expressed in Escherichia coli grown in medium containing copper and cadmium
19. Comparative studies on the distribution of gold, copper and zinc in the livers and kidneys of rats and hamsters after treatment with sodium [195Au]-aurothiomalate
20. Oxidative and nonoxidative mechanisms of site-specific DNA cleavage induced by copper-containing metallothioneins
21. Direct visualization of coppermetallothionein in LEC rat kidneys: Application of autofluoresence signal of copper-thiolate cluster
22. In situ blotting: A novel method for direct transfer of native proteins from sectioned tissue to blotting membrane: Procedure and some applications
23. Site-specific oxidative DNA damage at polyguanosine produced by copper plus hydrogen peroxide
24. The effect of gold on copper and zinc in kidney and in metallothionein
25. Relative gold-binding capacity of metallothionein: Studies in renal cytosols of gold-injected rats
26. Localization of renal Cubinding metallothionein induced by Au injection into rats
27. The effect of heavy metal-induced metallothionein on Zn, Cu and Cd accumulation in rat kidney
28. Quantitative immunohistochemical evaluation by image analysis of metallothionein in copper-loaded rat kidney
29. The binding of gold (I) to metallothionein
30. The binding of gold to cytosolic proteins of the rat liver and kidney: Metallothioneins
31. Effects of gold sodium thiomalate on cytosolic copper and zinc in the rat kidney and liver tissues
32. Gold nephropathy. A clinical and pathologic study
33. Copper-metallothionein from the toxic milk mutant mouse enhances lipid peroxidation initiated by an organic hydroperoxide
34. Copper-metallothionein in the kidney of macular mice: A model for Menkes disease
35. Histochemical demonstration of copper in normal rat brain and spinal cord. Evidence of localization in glial cells
36. Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase
37. Mutation spectrum of copper-induced DNA damage
38. The nephrotic syndrome as a complication of gold therapy
39. Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase
40. Hydroxyl free radical is not the main active species in site-specific DNA damage induced by copper (II) ion and hydrogen peroxide