The effect of heavy metal-induced metallothionein on Zn, Cu and Cd accumulation in rat kidney

Pharmacology and Toxicology

Volumn 84, Issue 6, 1999, Pages 255-260

  Saito, Shigeru ^a   Okabe, Masashi ^b   Yoshida, Katsumi ^a   Kurasaki, Masaaki ^b  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; COPPER; HEAVY METAL; METALLOTHIONEIN; ZINC;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DOSE TIME EFFECT RELATION; KIDNEY; KIDNEY DISEASE; MALE; METAL BINDING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICOLOGY;

EID: 0033052765     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1999.tb01491.x     Document Type: Article

References (19)

1. Eaton, D. L., N. H. Stacey, K.-L. Wong & C. D. Klaassen: Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heme oxygenase, and cytochrome p-450. Toxicol. Appl. Pharmacol. 1980, 55, 393-402.
2. Hamer, D. H.: Metallothionein. Annu. Rev. Biochem. 1986, 55, 913-951.
3. Kägi, J. H. R.: Overview of metallothionein. Methods Enzymol. 1991, 205, 613-626.
4. Kägi, J. H. R.: Evolution, structure and chemical activity of class I metallothioneins: An overview. In: Metallothionein III, Eds.: K. T. Suzuki, N. Imura, & M. Kimura. Birkhäuser Verlag Basel/ Switzerland, 1993, pp. 29-55.
5. Kägi, J. H. R. & A. Schäffer: Biochemistry of metallothionein. Biochemistry 1988, 27, 8509-8515.
6. Kojima, Y. & J. H. R. Kägi: Metallothionein. Trends Biochem. Sci. 1978, 3, 90-93.
7. Onosaka, S. & M. G. Cherian: The induced synthesis of metallothionein in various tissues of rats in response to metals. I. Effect of repeated injection of cadmium salts. Toxicology 1981, 22, 91-101.
8. Onosaka, S. & M. G. Cherian: The induced synthesis of metallothionein in various tissues of rats in response to metals. II. Influence of zinc status and specific effect on pancreatic metallothionein. Toxicology 1982, 23, 11-20.
9. Otvos, J. D. & I. M. Armitage: Structure of the metal clusters in rabbit liver metallothionein. Proc. Natl. Acad. Sci. USA 1980, 77, 7094-7098.
10. Richards, M. P. & R. J. Cousins: Mammalian zinc homeostasis: Requirement for RNA and metallothionein synthesis. Biochem. Biophys. Res. Commun. 1975, 64, 1215-1223.
11. Rupp. H. & U. Weser: Circular dichroism of metallothioneins. Biochim. Biophys. Acta 1978, 533, 209-226.
12. Saito, S. & P. E. Hunziker: Differential sensitivity of metallothionein-1 and -2 in liver of zinc-injected rat toward proteolysis. Biochim. Biophys. Acta 1996, 1289, 65-70.
13. Saito, S., M. Okabe & M. Kurasaki: Localization of renal Cu-binding metallothionein induced by Au injection into rats. Biochim. Biophys. Acta 1997, 1335, 353-358.
14. Saito, S. & Y. Kojima: Differential role of metallothionein on Zn, Cd and Cu accumulation in hepatic cytosol of rats. Cell. Mol. Life Sci. 1997, 53, 267-270.
15. Tohyama, C., M. Satoh, N. Kodama, H. Nishimura, A. Choo, A. Michalska, Y. Kanayama & A. Naganuma: Reduced retention of cadmium in the liver of metallothionein-null mice. Environ. Toxicol. Pharmacol. 1996, 1, 213-216.
16. Vasak, M. & J. H. R. Kägi: Metal thiolate clusters in cobalt (II) metallothionein. Proc. Natl. Acad. Sci. USA 1981, 78, 6709-6713.
17. Vasak, M., J. H. R. Kägi, B. Holmquist & B. L. Vallee: Spectral studies of cobalt (II)-and nickel (II)-metallothionein. Biochemistry 1981, 20, 6659-6664.
18. Waalkes, M. P. & C. D. Klaassen: Concentration of metallothionein in major organs of rats after administration of various metals. Fundam. Appl. Toxicol. 1985, 5, 473-477.
19. Webb, M.: The metallothioneins. In: The chemistry, biochemistry and biology of cadmium. Ed.: M. Webb, Elsevier/North Holland, Amsterdam, New York, Oxford, 1979, 195-266.