Potentiation of slow component of delayed rectifier K+ current by cGMP via two distinct mechanisms: Inhibition of phosphodiesterase 3 and activation of protein kinase G

British Journal of Pharmacology

Volumn 137, Issue 1, 2002, Pages 127-137

  Shimizu, Kentaro ^a   Shintani, Yutaka ^a   Ding, Wei Guang ^a   Matsuura, Hiroshi ^a   Bamba, Tadao ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

8 bromo cyclic GMP; Atrial natriuretic peptide; CGMP; Cyclic GMP inhibited phosphodiesterase; Guinea pig; Milrinone; Protein kinase G; Sino atrial node cells

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 4 CHROMANONE DERIVATIVE; 8 BROMO CYCLIC AMP; 8 BROMO CYCLIC GMP; ATRIAL NATRIURETIC FACTOR; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; ISOBUTYLMETHYLXANTHINE; KT 5823; MILRINONE; NISOLDIPINE; PHOSPHODIESTERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GUINEA PIG; NONHUMAN; PATCH CLAMP; PIPETTE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SINUS NODE;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ATRIAL NATRIURETIC FACTOR; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DELAYED RECTIFIER POTASSIUM CHANNELS; ENZYME ACTIVATION; FEMALE; GUINEA PIGS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PHOSPHODIESTERASE INHIBITORS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; SINOATRIAL NODE;

EID: 0036729769     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704843     Document Type: Article

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