Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation

Nature Genetics

Volumn 32, Issue 1, 2002, Pages 195-200

  Lee, Jeannie T ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ARTICLE; BLASTOCYTE; FEMALE; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; GENOTYPE; INFERTILITY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEX RATIO; TROPHOBLAST; X CHROMOSOME INACTIVATION;

ANIMALS; CROSSES, GENETIC; DOSAGE COMPENSATION, GENETIC; FEMALE; HOMOZYGOTE; MALE; MICE; MICE, INBRED C57BL; MUTATION; RNA, ANTISENSE; RNA, UNTRANSLATED; SEX RATIO; TRANSCRIPTION FACTORS; TROPHOBLASTS; X CHROMOSOME;

ANIMALIA;

EID: 0036727705     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng939     Document Type: Article

References (30)

1. Tsix, a gene antisense to Xist at the X-inactivation center
2. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
3. The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus
4. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus
5. Targeted mutagenesis of Tsix leads to nonrandom X-inactivation
6. A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice
7. Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells
8. Gene action in the X-chromosome of the mouse (Mus musculus L.)
9. X-chromosome inactivation: Counting, choice, and initiation
10. 40 Years of decoding the silence in X-chromosome inactivation
11. Preferential inactivation of the paternally derived X-chromosome in the extraembryonic membranes of the mouse
12. Imprinted X inactivation in eutherians: A model of gametic execution and zygotic relaxation
13. Requirement for Xist in X chromosome inactivation
14. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix
15. Regulation of imprinted X-chromosome inactivation in mice by Tsix
16. X-chromosome inactivation in XX androgenetic mouse embryos surviving implantation
17. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
18. Methylation of a CTCF-dependent boundary controls imprinted expression of the lgf2 gene
19. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/lgf2 locus
20. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
21. CTCF, a candidate trans-acting factor for X-inactivation choice
22. Autosomal dominant mutations affecting X inactivation choice in the mouse
23. X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse
24. The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status
25. Confirmation of maternal transmission ratio distortion at Om and direct evidence that the maternal and paternal 'DDK syndrome' genes are linked
26. Controlling elements in the mouse. V. Linkage tests with X-linked genes
27. Role of the Xist gene in X chromosome choosing
28. A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation
29. X-inactivation by chromosomal pairing events
30. Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation