Myotonic dystrophy protein kinase of the cardiac muscle: Evaluation using an immunochemical approach

Microscopy Research and Technique

Volumn 58, Issue 5, 2002, Pages 404-411

  Schiavon, Giorgia ^a   Furlan, Sandra ^a   Marin, Oriano ^a   Salvatori, Sergio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Cardiac muscle; Connexin 43; DMPK; Gap junctions; Phosphorylation

Indexed keywords

ENZYMES; FLUORESCENCE; HEART; MUSCLE;

CARDIAC MUSCLES; CONNEXIN 43; DM PROTEIN KINASE; GAP-JUNCTIONS; LOCALISATION; MULTI SYSTEMS; MYOTONIC DYSTROPHY; PROTEIN KINASE; TRINUCLEOTIDES; UNTRANSLATED REGIONS;

ANTIBODIES;

CONNEXIN 43; MYOTONIC DYSTROPHY PROTEIN KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME DEFECT; GENE; GENETIC POLYMORPHISM; HEART MUSCLE; IMMUNOBLOTTING; IMMUNOCHEMISTRY; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; MALE; MYOTONIC DYSTROPHY; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM; SYSTEMIC DISEASE; TRINUCLEOTIDE REPEAT;

EID: 0036727092     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.10223     Document Type: Article

References (51)

1. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model
2. Identification of a protein product of the myotonic dystrophy gene using peptide specific antibodies
3. Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member
4. Localization of myotonic dystrophy protein kinase in skeletal muscle and its alteration with disease
5. An unstable triplet repeat in a gene related to myotonic muscular dystrophy
6. Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy
7. Bulk isolation of mouse hepatocyte gap junctions
8. Expanding complexity in myotonic dystrophy
9. Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties
10. Localization of the myotonic dystrophy locus to 19q13.2-19q13.3 and its relationship to twelve polymorphic loci on 19q
11. Isolation and characterization of liver gap junctions
12. Anticipation in myotonic dystrophy: Fact or fiction?
13. Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs
14. Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice
15. Isolation of mouse myocardial gap junctions
16. Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocites
17. Trinucleotide repeat expansion at the myotonic dystrophy locus reduces expression of DMAHP
18. Decreased myotonin-protein kinase in the skeletal and cardiac muscles in myotonic dystrophy
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart
21. Regulation of gap junctions by phosphorylation of connexins
22. cac2 kinase
23. Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication
24. Protein measurements with the Folin phenol reagent
25. Identification, tissue-specific expression, and subcellular localization of the 80- and 71-kDa forms of myotonic dystrophy kinase protein
26. Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene
27. Cytoplasmic surface and intramembrane components of rat heart gap junctional proteins
28. Myotonic dystrophy protein kinase expressed in rat cardiac muscle is associated with sarcoplasmic reticulum and gap junctions
29. Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies
30. Disruption of splicing regulated by CUG-binding protein in myotonic dystrophy
31. Cardiac disease in myotonic dystrophy
32. Mice lacking the myotonic dystrophy protein kinase develop a late onsert progressive myopathy
33. cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide
34. Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions
35. Identification and localization of the myotonic dystrophy gene product in skeletal and cardiac muscles
36. Evidence for localization of the myotonic dystrophy protein kinase to the terminal cisternae of the sarcoplasmic reticulum
37. Transient up-regulation of myotonic dystrophy protein kinase-binding protein, MKBP, and HSP27 in the neonatal myocardium
38. A novel isoform of myotonin protein kinase: Gene product of myotonic dystrophy is localized in the sarcoplasmic reticulum of skeletal muscle
39. Myopathologische beitrage I. Uber das klinische und anatomische bild des muskelschwundes der myotoniker
40. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase
41. Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues
42. Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene
43. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
44. Immunolocalization of myotonic dystrophy protein kinase in corbular and junctional sarcoplsmic reticulum of human cardiac muscle
45. Myotonic dystrophy kinase is a component of neuromuscular junctions
46. Myotonic dystrophy: Evidence for a possible dominant-negative RNA mutation
47. Investigation of myotonic dystrophy kinase isoform translocation and membrane association
48. Characterization of myotonic dystrophy kinase. (DMK) protein in human and rodent muscle and central nervouis tissue
49. Commentary: Myotonic dystrophy reviewed: Back to the future?