Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart

Human Molecular Genetics

Volumn 9, Issue 14, 2000, Pages 2167-2173

  Lam, L T ^a   Pham, Y C N ^a   thi Man, N ^a   Morris, G E ^a  

^a GLYNDWR UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; EPITOPE; HEART ENZYME; HOMEODOMAIN PROTEIN; MONOCLONAL ANTIBODY; MUSCLE ENZYME; PEPTIDE LIBRARY; PROTEIN KINASE; TRINUCLEOTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; CROSS REACTION; DNA LIBRARY; DNA SEQUENCE; ENZYME ACTIVE SITE; ENZYME ISOLATION; ENZYME LOCALIZATION; GENETIC CODE; HEART MUSCLE; HUMAN; HUMAN CELL; MOUSE; MYOTONIC DYSTROPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; SMOOTH MUSCLE; TRINUCLEOTIDE REPEAT;

ANIMALIA;

EID: 0034285015     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.14.2167     Document Type: Article

References (42)

1. An unstable triplet repeat in a gene related to myotonic muscular dystrophy
2. Molecular basis of myotonic dystrophy-expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member
3. Myotonic dystrophy mutation: An unstable CTG repeat in the 3' untranslated region of the gene
4. Myotonic dystrophy reviewed: Back to the future
5. Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues
6. Myotonic dystrophy-evidence for a possible dominant negative RNA mutation
7. Transcriptional abnormality in myotonic dystrophy affects DMPK but not neighboring genes
8. A novel homeodomain encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)(n) repeat
9. Structural organization and developmental expression pattern of the mouse WD repeat gene DMR N9 immediately upstream of the myotonic dystrophy locus
10. Decreased expression of myotonin protein kinase messenger RNA and protein in adult form of myotonic dystrophy
11. Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene
12. Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties
13. Identification of a protein product of the myotonic dystrophy gene using peptide specific antibodies
14. Decreased myotonin protein kinase in the skeletal and cardiac muscles in myotonic dystrophy
15. Myotonic dystrophy kinase is a component of neuromuscular junctions
16. Full-length myotonin protein kinase (72 kDa) displays serine kinase activity
17. Localisation of myotonic dystrophy protein kinase in skeletal muscle and its alteration with disease
18. Identification, tissue-specific expression, and subcellular localisation of the 80 kda and 71 kda forms of myotonic dystrophy kinase protein
19. Investigation of myotonic dystrophy kinase isoform translocation and membrane association
20. Characterization of myotonic dystrophy kinase (DMPK) protein in human and rodent muscle and central nervous tissue
21. Evidence for localisation of the myotonic dystrophy protein kinase to the terminal cisternae of the sarcoplasmic reticulum
22. Identification and localisation of the myotonic dystrophy gene product in skeletal and cardiac muscles
23. Novel isoform of myotonin protein kinase gene product of myotonic dystrophy is localized in the sarcoplasmic reticulum of skeletal muscle
24. Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies
25. Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization
26. Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases
27. Cloning and chromosomal localization of human Cdc42-binding protein kinase beta
28. No imprinting involved in the expression of DM-kinase mRNAs in mouse and human tissues
29. Reiterative screening of phage-display peptide libraries with antibodies
30. Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice
31. Effect of the myotonic dystrophy (DM) mutation on mRNA levels of the DM gene
32. Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy
33. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model
34. The p160 RHOA binding kinase ROK-alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
35. The small GTP binding protein RHO binds to and activates a 160 kda Ser/Thr protein kinase homologous to myotonic dystrophy kinase
36. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
37. The protein kinase resource
38. Treatment of human muscle creatine kinase with glutaraldehyde preferentially increases the immunogenicity of the native conformation and permits production of high-affinity monoclonal antibodies which recognize two distinct surface epitopes
39. Monoclonal antibodies for dystrophin analysis: Epitope mapping and improved binding to SDS-treated muscle sections
40. Production of panels of monoclonal antibodies by the hybridoma method
41. Localisation of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: Presence at neuromuscular junctions, in the sarcolemma of dystrophin skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines