Brain glucose sensing mechanism and glucose homeostasis

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 5, Issue 5, 2002, Pages 539-543

  Pénicaud, Luc ^a   Leloup, Corinne ^a   Lorsignol, Anne ^a   Alquier, Thierry ^a   Guillod, Elise ^a  

^a CNRS   (France)

Author keywords

Astrocyte; Glucokinase; Glucose sensor; Glucose transporter 2; Metabolic disorders; Neurone

Indexed keywords

POTASSIUM; GLUCOSE;

BRAIN CELL; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BRAIN LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPOGLYCEMIA; MOLECULAR BIOLOGY; NEUROENDOCRINE DISEASE; OBESITY; POTASSIUM TRANSPORT; REVIEW; SENSOR; BLOOD; BRAIN; BRAIN STEM; CYTOLOGY; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HYPOTHALAMUS; METABOLISM; NEUROSECRETION; PANCREAS ISLET; PHYSIOLOGY; SECRETION;

BLOOD GLUCOSE; BRAIN; BRAIN STEM; GLUCOSE; HOMEOSTASIS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOTHALAMUS; ISLETS OF LANGERHANS; NEUROSECRETORY SYSTEMS;

EID: 0036725546     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-200209000-00013     Document Type: Review

References (38)

1. Pénicaud L, Cousin B, Leloup C, et al. The autonomic nervous system, adipose tissue plasticity and energy balance. Nutrition 2000; 16:903-908.
2. Mayer J. Regulation of energy intake and the body weight: the glucostatic and lipostatic hypothesis. Ann N Y Acad Sci 1955; 63:15-24.
3. Oomura Y, Ono T, Ooyama H, Wayner MJ. Glucose and osmosensitive neurons of the rat hypothalamus. Nature 1969; 247:284-286.
4. Levin BE. Glucosensing neurons do more than just sense glucose. Int J Obes Relat Metab Disord 2001; 25:S68-S72. A paper on the role of the glucosensing neurones.
5. Thorens B. GLUT2 in pancreatic and extra-pancreatic gluco-detection. Mol Membr Biol 2001; 18:265-273. A review on the role of Glut2 in different tissues including the brain.
6. Schuit FC, Huypens P, Heimberg H, Pipeleers DG. Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 2001; 50:1-11. A thorough review of glucose sensing in the pancreatic β cell and the similarities and differences with other glucose sensing cells including neurones.
7. Leloup C, Arluison M, Lepetit N, et al. Glucose transporter 2 (Glut2): expression in specific brain nuclei. Brain Res 1994; 638:221-226.
8. Jetton TL, Liang Y, Pettepher CC, et al. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and the gut. J Biol Chem 1994; 269:3641-3654.
9. Levin BE, Dunn-Meynell AA, Routh VH. Brain glucose sensing and body energy homeostasis: role in obesity and diabetes. Am J Physiol Regul Integr Comp Physiol 1999; 276:R1223-R1231.
10. Maekawa F, Toyoda Y, Torii N, et al. Localization of glucokinase-like immunoreactivity in the rat lower brain stem: for possible location of brain glucose-sensing mechanisms. Endocrinology 2000; 141:375-384.
11. Roncero I, Alvarez E, Vazquez P, Blazquez E. Functional glucokinase isoforms are expressed in rat brain. J Neurochem 2000; 74:1848-1857.
12. Alvarez E, Roncero I, Chowen JA, et al. Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brain. J Neurochem 2002; 80:45-53.
13. Liss B, Roeper J. Molecular physiology of neuronal K-ATP channels. Mol Membr Biol 2001; 18:117-127. A review on the molecular and cellular mechanism of the K-ATP channels focusing particularly on brain expression and role.
14. Ashford MLJ, Boden PR, Treherne JM. Glucose-induced excitation of rat hypothalamic neurones is mediated by ATP-sensitive K+ channels. Pflügers Archiv 1990; 415:479-483.
15. Reimann F, Aschcroft FM. Inwardly rectifying potassium channels. Curr Opin Cell Biol 1999; 11:503-508.
16. Yang XJ, Kow LM, Funabashi T, Mobbs CV. Hypothalamic glucose sensor: similarities to and differences from pancreatic β cell mechanisms. Diabetes 1999; 48:1763-1772.
17. Leloup C, Orosco M, Serradas P, et al. Specific inhibition of Glut2 in arcuate nucleus by antisense oligonucleotides suppresses nervous control of insulin secretion. Mol Brain Res 1998; 57:275-280.
18. Wan HZ, Husley MG, Martin RJ. Intracerebroventricular administration of antisense oligonucleotide against Glut2 transporter mRNA reduces food intake, body weight change and glucoprivic feeding in rats. J Nutr 1998; 128:287-291.
19. Burcelin R, Dolci W, Thorens B. Glucose sensing by the hepatoportal sensor is Glut2-dependent. In vivo analysts in Glut2-null mice. Diabetes 2000; 49:1643-1648.
20. Guenat E, Scheematter G, Philippe J, et al. Counterregulatory responses to hypoglycemia in patients with glucokinase gene mutations. Diabetes Metab 2000; 26:377-384.
21. Miki T, Liss B, Minami K, et al. ATP-sensitive potassium channels in ventromedial hypothalamic neurons play an essential role in the maintenance of glucose homeostasis, by controlling glucagon release and food intake. Nat Neurosci 2001; 4:507-512.
22. Ngarmukos C, Baur EL, Kumagai AK. Colocalization of Glut1 and Glut4 in the blood-brain barrier of the rat ventromedial hypothalamus. Brain Res 2001; 900:1-8.
23. Lee K, Dixon AK, Richardson PJ, Pinnock RD. Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. J Physiol 1999; 515:439-452.
24. Zhou M, Tanaka O, Sekiguchi M, et al. Localization of the ATP-sensitive potassium channel sub-unit (Ktr6.1/uK(ATP)-1) in rat brain. Mol Brain Res 1999; 74:15-25.
25. Young JK, Baker JH, Montes MI. The brain response to 2-deoxy glucose is blocked by a glial drug. Pharmacol Biochem Behav 2000; 67:233-239.
26. Young JK, Baker JH, Müller T. Immunoreactivity for brain fatty acid binding protein in Gomori-positive astrocytes. Glia 1996; 16:218-226.
27. Pellerin L, Pellegri G, Bittar PG, et al. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev Neurosci 1998; 20:291-299.
28. Himmi T, Perrin J, Dallaporta M, Orsini JC. Effects of lactate on glucose-sensing neurons in the solitary tract nucleus. Physiol Behav 2001; 74:391-397. In-vivo evidence in support of the influence of lactate acts on glucose responsive neurones.
29. Forsyth R, Fray A, Boutelle M, et al. A role for astrocytes in glucose delivery to neurons? Dev Neurosci 1996; 18:360-370.
30. Williams G, Bing C, Cai XJ, et al. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav 2001; 74:683-701. A recent review on the role of the hypothalamus in energy balance and the neuronal pathways and peptides involved.
31. Leloup C, Arluison M, Kassis N, et al. Discrete brain areas express the insulin-responsive glucose transporter Glut4. Mol Brain Res 1996; 38:45-53.
32. El Messari S, Leloup C, Quignon M, et al. Immunocytochemical localization of the insulin-responsive glucose transporter Glut4 in the rat central nervous system. J Comp Neurol 1998; 399:492-512.
33. Spanswick D, Smith MA, Groppi VE, et al. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nat Neurosci 2000; 8:757-759.
34. Spanswick D, Smith MA, Mirshamsi S, et al. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean but not obese rats. Nature Neurosci 2000; 8:757-759.
35. Mobbs CV, Kow LM, Yang XJ. Brain glucose-sensing mechanisms: ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses. Am J Physiol Endocrinol Metab 2001; 281:E649-E654. An excellent review discussing the various types of glucose sensing neurones with regard to the intensity of changes in glucose concentration.
36. Song Z, Levin BE, McArdle JJ, et al. Convergence of pre and postsynaptic influences on glucosensing neurons in ventromedial hypothalamic nucleus. Diabetes 2001; 50:2673-2681. A very important paper in the field, leading to reconsideration of the classification of the different subtypes of neurones responding to physiological changes in glucose levels.
37. Rowe IC, Boden PR, Ashford MLJ. Potassium channel dysfunction in hypothalamic glucose-receptive neurones of obese Zucker rats. J Physiol 1996; 497:365-377.
38. Alquier T, Leloup C, Arnaud E, et al. Altered Glut4 mRNA levels in specific brain areas of hyperglycemic-hyperinsulinemic rats. Neurosci Lett 2001; 308:75-78. Data in support of an alteration in the components of the glucose sensing system in the brain in an experimental model of metabolic disease.