Protein, amino acid and nitrogen metabolism during pregnancy: How might the mother meet the needs of her fetus?

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 5, Issue 5, 2002, Pages 503-509

  Duggleby, Sarah L ^a   Jackson, Alan A ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; NITROGEN; PROTEIN; UREA;

AMINO ACID METABOLISM; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DEVELOPMENTAL DISORDER; DIETARY INTAKE; FETUS; FETUS GROWTH; HUMAN; INTRAUTERINE GROWTH RETARDATION; ISOTOPE LABELING; MATERNAL NUTRITION; METABOLIC DISORDER; MOTHER FETUS RELATIONSHIP; NITROGEN METABOLISM; PLACENTA DEVELOPMENT; PREGNANCY; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEIN SYNTHESIS; REVIEW; UREA CYCLE; ADAPTATION; BIRTH WEIGHT; ENERGY METABOLISM; FEMALE; METABOLISM; NUTRITIONAL REQUIREMENT; NUTRITIONAL STATUS; PHYSIOLOGY; PREGNANCY OUTCOME; PRENATAL DEVELOPMENT;

ADAPTATION, PHYSIOLOGICAL; AMINO ACIDS; BIRTH WEIGHT; DIETARY PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; ENERGY METABOLISM; FEMALE; HUMANS; NITROGEN; NUTRITIONAL REQUIREMENTS; NUTRITIONAL STATUS; PREGNANCY; PREGNANCY OUTCOME; PROTEINS; UREA;

EID: 0036725092     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-200209000-00008     Document Type: Review

References (44)

1. de Onis M, Blossner M, Villar J. Levels and patterns of intrauterine growth retardation in developing countries. Eur J Clin Nutr 1998; 52:35-315.
2. FAO/WHO/UNU. Energy and protein requirements: report of a joint FAO/WHO/UNU expert consultation. Report no. 724, World Health Organization Technical Report Series; 1985.
3. Rush D. Effects of changes in maternal energy and protein intake during pregnancy, with special reference to fetal growth. In: Sharp F, Fraser RB, Milner RDG, editors. Fetal growth. London: Springer; 1989. pp. 203-229.
4. Clapp JF, Seaward BL, Sleamaker RH, Hiser J. Maternal physiologic adaptations to early human pregnancy. Am J Obstet Gynecol 1988; 159:1456-1460.
5. Hegsted DM. Variation in requirements of nutrients: amino acids. Federation Proc 1963; 22:1424-1430.
6. van Raaij JMA, Peek MEM, Vermaat-Miedema SH, et al. New equations for estimating body fat mass in pregnancy from body density or total body water. Am J Clin Nutr 1988; 48:24-29.
7. Hytten FE, Leitch I. The physiology of human pregnancy. 2nd ed. Oxford: Blackwell Scientific Publications; 1971.
8. Galloway DH, King JC, Appel JA. Nutritional balance studies in pregnant women. In: Aebi H, Whitehead R, editors. Maternal nutrition during pregnancy and lactation. Bern: Hans Huber; 1980. pp. 75-85.
9. Mojtahedi M, de Groot LCPGM, Boekhoit HA, van Raaij JMA. Nitrogen balance of healthy Dutch women before and during pregnancy. Am J Clin Nutr 2002; 75:1078-1083. In this paper, women were studied longitudinally before and during pregnancy and, keeping energy and protein intake constant, the authors demonstrated an increase in nitrogen retention as gestation advanced. In contrast to many previous studies, values for retention were slightly lower than theoretical estimates of deposition.
10. Bingham SA. The dietary assessment of individuals: methods, accuracy, new techniques and recommendations. Nutr Abs Rev 1987; 57:705-742.
11. Macdiarmid JI, Blundell JE. Dietary under-reporting: what people say about recording their food intake. Eur J Clin Nutr 1997; 51:199-200.
12. Godfrey K, Robinson S, Barker DJP, et al. Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. BMJ 1996; 312:410-414.
13. Burke BS, Harding W, Stuart HC. Nutrition studies in pregnancy: IV. Relation of protein content of mother's diet during pregnancy to birth length, birth weight, and condition of infant at birth. J Pediatr 1943; 23:506-515.
14. Sontag LW, Wines J. Relation of mothers' diets to status of their infants at birth and in infancy. Am J Obstet Gynecol 1947; 54:994-1003.
15. Mathews F, Yudkin P, Neil A. Influence of maternal nutrition on outcome of pregnancy: prospective cohort study. BMJ 1999; 319:339-343.
16. Waterlow JC, Garlick PJ, Millward DJ. Protein turnover in mammalian tissues and in the whole body. Amsterdam: North-Holland; 1978.
17. Waterlow JC, Jackson AA. Nutrition and protein turnover in man. Br Med Bull 1981; 37:5-10.
18. 15N]glycine: comparison of single-dose and intermittent-dose regimens. Br J Nutr 1995; 74:491-507.
19. Pencharz PB, Steffee WP, Cochran W, et al. Protein metabolism in human neonates: nitrogen-balance studies, estimated obligatory losses of nitrogen and whole-body turnover of nitrogen. Clin Sci Mol Med 1977; 52:485-498.
20. Chien PFW, Smith K, Watt PW, et al. Protein turnover in the human fetus studied at term using stable isotope tracer amino acids. Am J Physiol 1993; 265:E31-E35.
21. de Benoist B, Jackson AA, Hall JStE, Persaud C. Whole-body protein turnover in Jamaican women during normal pregnancy. Hum Nutr Clin Nutr 1985; 39C:167-179.
22. Jackson AA, Measurement of protein turnover during pregnancy. Hum Nutr Clin Nutr 1987; 41C:497-498.
23. Thompson GN, Halliday D. Protein turnover in pregnancy. Eur J Clin Nutr 1992; 46:411-417.
24. Willommet L, Schutz Y, Whitehead R, et al. Whole body protein metabolism and resting energy expenditure in pregnant Gambian women. Am J Physiol 1992; 263:E624-E631.
25. Duggleby SL, Jackson AA. Relationship of maternal protein turnover and lean body mass during pregnancy and birth length. Clin Sci 2001; 101:65-72. The largest study of protein turnover carried out in pregnant women enabled the authors to determine for the first time the significance of protein turnover in relation to fetal growth. Mothers with a greater lean body mass (specifically visceral, rather than muscle mass) were found to have higher rates of turnover. Furthermore, rates of turnover were found to be related to the growth of the baby.
26. 15N]glycine to show changes with the menstrual cycle and pregnancy. Eur J Clin Nutr 2000; 54:329-336.
27. Fitch WL, King JC. Protein turnover and 3-methylhistidine excretion in non-pregnant, pregnant and gestational diabetic women. Hum Nutr Clin Nutr 1987; 41C:327-339.
28. Jackson AA. Critique of protein-energy interactions in vivo: urea kinetics. In: Scrimshaw NS, Schurch B, editors. Protein-energy interactions. Lausanne: IDECG; 1992. pp. 83-79.
29. Kalhan SC, Tserng K-Y, Gilfillan C, Dierker LJ. Metabolism of urea and glucose in normal and diabetic pregnancy. Metabolism 1982; 31:824-833.
30. Kalhan SC, Rossi KQ, Gruca LL, et al. Relation between transamination of branched-chain amino acids and urea synthesis: evidence from human pregnancies. Am J Physiol 1998; 275:E423-E431.
31. Forrester T, Badaloo AV, Persaud C, Jackson AA. Urea production and salvage during pregnancy in normal Jamaican women. Am J Clin Nutr 1994; 60:341-346.
32. Duggleby SL, Jackson AA. Increased weight at birth is related to amino acid oxidation during human pregnancy. Am J Clin Nutr (in press). This study on 25 pregnant women explored further how protein metabolism might impact on the growth of the fetus. The authors showed that there was an association between the change in amino acid oxidation and the weight of the baby.
33. McClelland ISM, Persaud C, Jackson AA. Urea kinetics in healthy women during normal pregnancy. Br J Nutr 1997; 77:165-181.
34. 15N]urea in free living humans. J Nutr 1993; 123:2129-2136.
35. McClelland ISM, Jackson AA. Urea kinetics in healthy young women: minimal effect of stage of menstrual cycle, contraceptive pill and protein intake. Br J Nutr 1996; 76:199-209.
36. Widdowson EM. Chemical composition and nutritional needs of the fetus at different stages of gestation. In: Aebi H, Whitehead R, editors. Maternal nutrition during pregnancy and lactation. Bern: Hans Huber; 1980. pp. 39-48.
37. Farmer G, Russell G, Hamilton-Nicol DR, et al. The influence of maternal glucose metabolism on fetal growth, development and morbidity in 917 singleton pregnancies in nondiabetic women. Diabetologia 1988; 31:134-141.
38. Langhoff-Roos J, Wibell L, Gebre-Medhin M, Lindmark G. Maternal glucose metabolism and infant birth weight: a study in healthy pregnant women. Diabetes Res 1988; 8:165-170.
39. Wootton SA, Jackson AA. Influence of under-nutrition in early life on growth, body composition and on metabolic competence. In: Henry CJK, Ulijaszek SJ, editors. Long-term consequences of early environment: growth, development and the lifespan developmental perspective. Cambridge: Cambridge University Press; 1996. pp. 109-123.
40. Jackson AA. Maternal and fetal demands for nutrients: significance of protein metabolism. In: O'Brien PMS, Wheeler T, Barker DJP, editors. Fetal programming: influences on development and disease in later life. London: RCOG; 1999. pp. 246-270.
41. Rao S, Yajnik CS, Kanade A, et al. Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune Maternal Nutrition Study. J Nutr 2001; 131:1217-1224.
42. Barker DJP. Mothers, babies and health in later life. 2nd ed. London: Churchill Livingstone; 1998.
43. Law CM, Shiell AW. Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature. J Hypertens 1996; 14:935-941.
44. Jackson, AA, Robinson S, Duggleby S. Addressing low birthweight through interventions in adolescence. In: Technical consultation on low birthweight. New York: UNICEF NYHQ; 2000. pp. 36-42.