Deciphering the immune pathomechanism of cutaneous drug reactions

Allergy: European Journal of Allergy and Clinical Immunology, Supplement

Volumn 57, Issue 72, 2002, Pages 34-36

  Pichler, Werner J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cytotoxicity; Drug allergy; Eotaxin; Exanthema; IL 5; Nencovalent binding; T cells

Indexed keywords

GLUTARALDEHYDE; LIDOCAINE; SULFAMETHOXAZOLE; DRUG;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; CONFERENCE PAPER; DRUG BINDING; DRUG HYPERSENSITIVITY; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SKIN MANIFESTATION; T LYMPHOCYTE; ARTICLE; DRUG ERUPTION; IMMUNOLOGY; METABOLISM; SKIN;

DRUG ERUPTIONS; DRUG HYPERSENSITIVITY; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; PHARMACEUTICAL PREPARATIONS; SKIN; T-LYMPHOCYTES; HUMANS;

EID: 0036724033     PISSN: 01081675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. Incidence of adverse drug reactions in hospitalized patients
2. Drug-induced hypersensitivity syndrome. A review and presentation of 2 personal cases
3. Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective
4. Sulphamethoxazole is metabolised to the hydroxylamine in humans
5. Characterization of lidocaine specific T cells
6. Direct, MHC dependent presentation of the drug sulfamethoxazole to human αβ T cell clones
7. HLA restricted, processing and metabolism independent pathway of drug recognition by human αβ + T lymphocytes
8. Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions
9. T cell mediated cytotoxicity against keratinocytes in sulphamethoxazole induced skin reactions
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12. Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions
13. Adverse drug reactions in Sjögren syndrome: Frequent allergic reactions and a specific trimethoprim-associated systemic reaction