The O4 specific antigen moiety of lipopolysaccharide but not the K54 group 2 capsule is important for urovirulence of an extraintestinal isolate of Escherichia coli

Infection and Immunity

Volumn 64, Issue 6, 1996, Pages 2343-2348

  Russo, Thomas A ^a,c   Brown, Jennifer J ^b   Jodush, Stephen T ^a   Johnson, James R ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c Biomedical Research Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; ESCHERICHIA COLI; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOGENESIS; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; URINARY TRACT INFECTION;

EID: 0030004189     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.6.2343-2348.1996     Document Type: Article

References (56)

1. Abe, C., S. Schmitz, B. Jann, and K. Jann. 1988. Monoclonal antibodies against O and K antigens of uropathogenic Escherichia coli O4:K12:H- as opsonins. FEMS Microbiol. Lett. 51:153-158.
2. Acquatella, H., P. J. Little, H. E. deWardener, and J. C. Coleman. 1967. The effect of urine osmolality and pH on the bactericidal activity of plasma. Clin. Sci. 33:471-480.
3. Allen, P. M., I. Roberts, G. J. Boulnois, J. R. Saunders, and C. A. Hart. 1987. Contribution of capsular polysaccharide and surface properties to virulence of Escherichia coli K1. Infect. Immun. 55:2662-2668.
4. Beeson, P. B., and D. Rowley. 1959. The anticomplementary effect of kidney tissue. J. Exp. Med. 110:685-697.
5. Chernew, I., and A. I. Braude. 1962. Depression of phagocytosis by solutes in concentrations found in kidney and urine. J. Clin. Invest. 41:1945-1953.
6. Cross, A. S., P. Gemski, J. C. Sadoff, F. Orskov, and I. Orskov. 1984. The importance of the K1 capsule in invasive infections caused by Escherichia coli. J. Infect. Dis. 149:184-193.
7. Cross, A. S., K. S. Kim, C. Wright, J. C. Sadoff, and P. Gemski. 1986. Role of lipopolysaccharide and capsule in the serum resistance of bacteremic strains of Escherichia coli. J. Infect. Dis. 154:497-503.
8. Cross, A. W. 1990. The biologic significance of bacterial encapsulation. Curr. Top. Microbiol. Immunol. 150:87-95.
9. Domingue, G. J., R. Laucirica, P. Baliga, S. Covington, J. A. Robledo, and S. C. Li. 1988. Virulence of wild-type E. coli uroisolates in experimental pyelonephritis. Kidney Int. 34:761-765.
10. Donnenberg, M. S., and R. A. Welch. 1996. Virulence determinants of uropathogenic Escherichia coli, p. 135-174. In H. Mobley and J. Warren (ed.), Urinary tract infections: molecular pathogenesis and clinical management. American Society for Microbiology, Washington, D.C.
11. Ge, Y., R. M. Ezzell, R. G. Tompkins, and H. S. Warren. 1994. Cellular distribution of endotoxin after injection of chemically purified lipopolysaccharide differs from that after injection of live bacteria. J. Infect. Dis. 169: 95-104.
12. Hagberg, L., I. Engberg, R. Freter, J. Lam, S. Olling, and C. Svanborg Edén. 1983. Ascending, unobstructed urinary tract infection in mice caused by pyelonephritogenic Escherichia coli of human origin. Infect. Immun. 40:273-283.
13. Hitchcock, P. J., and T. M. Brown. 1983. Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels. J. Bacteriol. 154:269-277.
14. Jann, K., and B. Jann. 1987. Polysaccharide antigens of Escherichia coli. Rev. Infect. Dis. 9:S517-S526.
15. Johnson, J. Unpublished data.
16. Johnson, J. R. 1991. Virulence factors in Escherichia coli urinary tract infections. Clin. Microbiol. Rev. 4:80-128.
17. Johnson, J. R., T. Berggren, and J. C. Manivel. 1991. Histopathologic-microbiologic correlates in a mouse model of ascending unobstructed urinary tract infection. J. Infect. Dis. 165:299-305.
18. Johnson, J. R., T. Berggren, D. S. Newburg, R. H. McCluer, and J. C. Manivel. 1992. Detailed histopathological examination contributes to the assessment of Escherichia coli urovirulence. J. Urol. 147:1160-1166.
19. Johnson, J. R., and J. J. Brown. 1996. Defining inoculation conditions for the mouse model of ascending urinary tract infection that avoid immediate vesicoureteral reflux yet produce renal and bladder infection. J. Infect. Dis. 173:746-749.
20. Johnson, J. R., M. F. Lyons II, W. Pearce, P. Gorman, P. L. Roberts, N. White, P. Brust, R. Olsen, J. W. Gnann, Jr., and W. E. Stamm. 1991. Therapy for women hospitalized with acute pyelonephritis: a randomized trial of ampicillin versus trimethoprim-sulfamethoxazole for 14 days. J. Infect. Dis. 10:325-330.
21. Joiner, K. A. 1988. Complement evasion by bacteria and parasites. Annu. Rev. Microbiol. 42:201-230.
22. Kaijser, B. 1973. Immunology of Escherichia coli: K antigen and its relation to urinary tract infection. J. Infect. Dis. 127:670-677.
23. Kaijser, B., L. A. Hanson, U. Jodal, G. Lidin-Janson, and J. Robbins. 1977. Frequency of E. coli K antigens in urinary-tract infections in children. Lancet i:663-664.
24. Kalmanson, G. M., H. J. Harwick, M. Turck, and L. B. Guze. 1975. Urinary-tract infection: localisation and virulence of Escherichia coli. Lancet i:134-136.
25. Kim, K. S., H. Itabashi, P. Gemski, J. Sadoff, R. L. Warren, and A. S. Cross. 1992. The K1 capsule is the critical determinant in the development of Escherichia coli meningitis in the rat. J. Clin. Invest. 90:897-905.
26. Leying, H., S. Suerbaum, H.-P. Kroll, D. Stahl, and W. Opferkuch. 1990. The capsular polysaccharide is a major determinant of serum resistance in K-1-positive blood culture isolates of Escherichia coli. Infect. Immun. 58:222-227.
27. Medearis, D. N., Jr., B. A. Camilla, and E. C. Heath. 1968. Cell wall composition and virulence in Escherichia coli. J. Exp. Med. 128:399-414.
28. Nalanson, C., W. D. Hoffman, A. F. Suffredini, P. Q. Eichacker, and R. L. Danner. 1994. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann. Intern. Med. 120:771-783.
29. Nicholson, A. M., and A. A. Glynn. 1975. Investigation of the effect of K antigen in Escherichia coli urinary tract infections by use of a mouse model. Br. J. Exp. Pathol. 56:549-553.
30. Norden, C. W., G. M. Green, and E. H. Kass. 1968. Antibacterial mechanisms of the urinary bladder. J. Clin. Invest. 47:2689-2700.
31. O'Hanley, P., G. Lalonde, and G. Ji. 1991. Alpha-hemolysin contributes to the pathogenicity of piliated digalactoside-binding Escherichia coli in the kidney: efficacy of an alpha-hemolysin vaccine in preventing renal injury in the BALB/c mouse model of pyelonephritis. Infect. Immun. 59:1153-1161.
32. O'Hanley, P., D. Low, I. Romero, D. Lark, K. Vosti, S. Falkow, and G. Schoolnik. 1985. Gal-Gal binding and hemolysin phenotypes and genotypes associated with uropathogenic Escherichia coli. N. Engl. J. Med. 313:414-420.
33. Orskov, F. 1976. Agarose electrophoresis combined with second dimensional Cetavlon precipitation. A new method for demonstration of acidic polysaccharide K antigens. Acta Pathol. Microbiol. Scand. 84:319-320.
34. Orskov, I., and F. Orskov. 1985. Escherichia coli in extraintestinal infections. J. Hyg. 95:551-575.
35. Pelkonen, S., J. Hayrinen, and J. Finne. 1988. Polyacrylamide gel electrophoresis of the capsular polysaccharides of Escherichia coli K1 and other bacteria. J. Bacteriol. 170:2646-2653.
36. Pluschke, G., J. Mayden, M. Achtman, and R. P. Levine. 1983. Role of the capsule and the O antigen in resistance of O18:K1 Escherichia coli to complement-mediated killing. Infect. Immun. 42:907-913.
37. Porat, R., M. A. Johns, and W. R. McCabe. 1987. Selective pressures and lipopolysaccharide subunits as determinants of resistance of clinical isolates of gram-negative bacilli to human serum. Infect. Immun. 55:320-328.
38. Russo, T. A., J. E. Guenther, S. Wenderoth, and M. M. Frank. 1993. Generation of isogenic K54 capsule-deficient Escherichia coli strains through TnphoA-mediated gene disruption. Mol. Microbiol. 9:357-364.
39. Russo, T. A., Y. Liang, and A. S. Cross. 1994. The presence of K54 capsular polysaccharide increases the pathogenicity of Escherichia coli In Vivo. J. Infect. Dis. 169:112-118.
40. Russo, T. A., M. C. Moffitt, C. H. Hammer, and M. M. Frank. 1993. TnphoA-mediated disruption of K54 capsular polysaccharide genes in Escherichia coli confers serum sensitivity. Infect. Immun. 61:3578-3582.
41. Russo, T. A., G. Sharma, C. R. Brown, and A. A. Campagnari. 1995. The loss of the O4 antigen moiety from the lipopolysaccharide of an extraintestinal isolate of Escherichia coli has only minor effects on serum sensitivity and virulence in vivo. Infect. Immun. 63:1263-1269.
42. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
43. Sandberg, T., B. Kaijser, G. Lidin-Janson, K. Lincoln, F. Ørskov, I. Ørskov, E. Stokland, and C. Svanborg-Eden. 1988. Virulence of Escherichia coli in relation to host factors in women with symptomatic urinary tract infection. J. Clin. Microbiol. 26:1471-1476.
44. Smith, H. W., and M. B. Huggins. 1980. The association of the O18, K1 and H7 antigens and the ColV plasmid of a strain of Escherichia coli with its virulence and immunogenicity. J. Gen. Microbiol. 121:387-400.
45. Stamm, W. E., G. W. Counts, K. R. Running, S. Fihn, M. Turck, and K. K. Holmes. 1982. Diagnosis of coliform infection in acutely dysuric women. N. Engl. J. Med. 307:463-468.
46. Stendahl, O., B. Normann, and L. Edebo. 1979. Influence of O and K antigens on the surface properties of Escherichia coli in relation to phagocytosis. Acta Pathol. Microbiol. Scand. Sect. B 87:85-91.
47. Suzuki, Y., F. Fukushi, S. Orikasa, and K. Kumagai. 1982. Opsonic effect of normal and infected human urine on phagocytosis of Escherichia coli and yeasts by neutrophils. J. Urol. 127:356-360.
48. Svanborg-Edén, C., L. Hagberg, R. Hull, S. Hull, K.-E. Magnusson, and L. Öhman. 1987. Bacterial virulence versus host resistance in the urinary tracts of mice. Infect. Immun. 55:1224-1232.
49. Taylor, P. W. 1983. Bactericidal and bacteriolytic activity of serum against gram-negative bacteria. Microbiol. Rev. 47:45-83.
50. Taylor, P. W., and K. G. Koutsaimanis. 1975. Experimental Escherichia coli urinary infection in the rat. Kidney Int. 8:233-238.
51. Timmis, K. N., G. J. Boulnois, D. Bitter-Suermann, and F. C. Cabello. 1985. Surface components of Escherichia coli that mediate resistance to the bactericidal activities of serum and phagocytes. Curr. Top. Microbiol. Immunol. 118:197-218.
52. Tsai, C. M., and C. E. Frasch. 1982. A sensitive silver stain for detecting lipopolysaccharide in polyacrylamide gels. Anal. Biochem. 119:115-119.
53. Vahlne, G. 1945. Occurrence of Bact. coli under normal and pathologic conditions, with special reference to the antigenic aspects. Acta Pathol. Microbiol. Scand. 63:1-127.
54. van den Bosch, J. F., P. Postma, P. A. R. Koopman, J. de Graaff, and D. M. MacLaren. 1982. Virulence of urinary and faecal Escherichia coli in relation to serotype, haemolysis and haemagglutination. J. Hyg. 88:567-577.
55. Verweij-van Vught, A. M. J. J., J. F. van den Bosch, F. Namavar, M. Sparrius, and D. M. MacLaren. 1983. K antigens of Escherichia coli and virulence in urinary-tract infection: studies in a mouse model. J. Med. Microbiol. 16:147-155.
56. Vosti, K. L., and E. Randall. 1970. Sensitivity of serologically classified strains of Escherichia coli of human origin to the serum bactericidal system. Am. J. Med. Sci. 259:114-119.