Mutational analysis of the class I β-tubulin gene in human breast cancer

International Journal of Cancer

Volumn 101, Issue 1, 2002, Pages 46-51

  Hasegawa, Seiichi ^a   Miyoshi, Yasuo ^a   Egawa, Chiyomi ^a   Ishitobi, Makoto ^a   Tamaki, Yasuhiro ^a   Monden, Morito ^a   Noguchi, Shinzaburo ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

tubulin; Breast cancer; Somatic mutation

Indexed keywords

BETA TUBULIN; TAXANE DERIVATIVE;

ARTICLE; BREAST CANCER; CANCER RESISTANCE; CODON; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSEUDOGENE; SINGLE STRAND CONFORMATION POLYMORPHISM;

BASE SEQUENCE; BREAST NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; FEMALE; HUMANS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PSEUDOGENES; TUBULIN;

EID: 0036722943     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10575     Document Type: Article

References (19)

1. Direct photoaffinity labeling of tubulin with Taxol
2. Taxol stabilizes microtubules in mouse fibroblast cells
3. Mechanism of mitotic block and inhibition of cell proliferation by Taxol at low concentrations
4. Biochemistry of multidrug resistance mediated by the multidrug transporter
5. The role of multidrug resistance-associated protein (MRP) expression in multidrug resistance
6. Structure and utilization of tubulin isotypes
7. Multiple forms of tubulin: Different gene products and covalent modifications
8. Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes
9. Tubulin isotypes and the multigene tubulin families
10. Preparation of a monoclonal antibody specific for the class IV isotype of beta-tubulin. Purification and assembly of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers from bovine brain
11. Microtubule dynamics in vitro are regulated by the tubulin isotype composition
12. Kinetics of colchicine binding to purified beta-tubulin isotypes from bovine brain
13. Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes
14. Expression of beta-tubulin isotypes in human ovarian carcinoma xenografts and in a sub-panel of human cancer cell lines from the NCI-Anticancer Drug Screen: Correlation with sensitivity to microtubule active agents
15. Paclitaxel resistance in non-small cell lung cancer associated with beta-tubulin gene mutations
16. Mutational analysis of the β-tubulin gene in lung cancer
17. Genetic analysis of the β-tubulin gene, TUBB, in non-small-cell lung cancer
18. Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization
19. Multiple microtubule alterations are associated with vinca alkaloid resistance in human leukemia cells