Cutting edge: Oral type I IFN-τ promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate

Journal of Immunology

Volumn 169, Issue 5, 2002, Pages 2231-2235

  Soos, Jeanne M ^a   Stüve, Olaf ^a   Youssef, Sawsan ^a   Bravo, Manuel ^a   Johnson, Howard M ^a   Weiner, Howard L ^a   Zamvil, Scott S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GLATIRAMER; INTERLEUKIN 10; MYELIN BASIC PROTEIN; TAU INTERFERON;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG POTENTIATION; FEMALE; IMMUNOMODULATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; TH2 CELL; TREATMENT PLANNING;

EID: 0036721792     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.5.2231     Document Type: Article

References (23)

1. Interferon β in the treatment of multiple sclerosis: Mechanisms of action
2. Mechanisms of action of glatiramer acetate in multiple sclerosis
3. Immunomodulatory effects of interferon β-1a in multiple sclerosis
4. Interferon (IFN) β acts downstream of IFN-γ-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-γ
5. Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1
6. Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis
7. Specific immunotherapy: One size does not fit all
8. Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1
9. Combinations of drugs
10. A trial to assess the safety of combining therapy with interferon β-1a and glatiramer acetate in patients with relapsing MS
11. Interferon-τ: Prospects for clinical use in autoimmune disease
12. The IFN pregnancy recognition hormone, IFN-τ, blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity
13. Oral feeding of interferon τ can prevent acute and chronic relapsing forms of experimental allergic encephalomyelitis
14. The T lymphocyte in experimental allergic encephalomyelitis
15. IFN-τ suppresses both the autoreactive humoral and cellular immune responses and induces stable remission in mice with chronic experimental allergic encephalomyelitis
16. Phase 1 study of oral recombinant ovine interferon-τ in relapsing-remitting multiple sclerosis
17. T cells with two functional antigen-specific receptors
18. Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity
19. Interferon-γsecreting cells in multiple sclerosis patients treated with interferon β-1b
20. Interferon effects on interleukin-10 secretion: Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients
21. Immunomodulation of experimental autoimmune encephalomyelitis by oral administration of copolymer 1
22. Combination therapy with glatiramer acetate (copolymer-1) and a type I interferon (IFN-α) does not improve experimental autoimmune encephalomyelitis
23. Ingested IFN-α: Results of a pilot study in relapsing-remitting MS