Amelioration of chronic and spontaneous intestinal inflammation with an antisense oligonucleotide (ISIS 9125) to intracellular adhesion molecule-1 in the HLA-B27/β2 microglobulin transgenic rat model

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 3, 2002, Pages 908-917

  Bowen Yacyshyn, M B ^a,c   Bennett, C F ^b   Nation, N ^a   Rayner, D ^a   Yacyshyn, B R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ISIS PHARMACEUTICALS   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BETA 2 MICROGLOBULIN; CD18 ANTIGEN; HLA B27 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; ISIS 9125; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CECUM; CELL ADHESION; CHRONIC DISEASE; COLON; CYTOKINE PRODUCTION; DRUG EFFICACY; ENDOTHELIUM CELL; ENTERITIS; FEMALE; HISTOPATHOLOGY; HLA SYSTEM; IMMUNOTHERAPY; LEUKOCYTE MIGRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STOMACH MUCOSA;

ADMINISTRATION, RECTAL; ANIMALS; BETA 2-MICROGLOBULIN; BODY WEIGHT; CELL ADHESION MOLECULES; CHRONIC DISEASE; CYTOKINES; ENTERITIS; FEMALE; HLA-B27 ANTIGEN; IMMUNOHISTOCHEMISTRY; INTERCELLULAR ADHESION MOLECULE-1; MALE; MICE; MICE, TRANSGENIC; OLIGORIBONUCLEOTIDES, ANTISENSE; ORGAN SIZE; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0036721232     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.036053     Document Type: Article

References (29)

1. Expression of carcinoembryonic antigen and nonspecific cross-reacting 50-kDa antigen in human normal and cancerous colon mucosa: Comparative ultrastructural study with monoclonal antibodies
2. Intercellular adhesion molecule-1 (ICAM-1) deficiency protects mice against severe forms of experimentally induced colitis
3. An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice
4. Effects of murine recombinant interleukin-10 on the inflammatory disease of rats transgenic for HLA-B27 and β2-microglobulin
5. The role of tumor necrosis factor in health and disease
6. Methoxyethyl modification of phosphorothioate ICAM-1 antisense oligonucleotides improves prevention of ischemic/reperfusion injury
7. Induction by IL-1 and interferon-Υ: Tissue distribution, biochemistry and function of a natural adherence molecule (ICAM-1)
8. Inhibition of dextran sulphate sodium (DSS)-induced colitis in mice by intracolonically administered antibodies against adhesion molecules (endothelial leukocyte adhesion molecule-1 (ELAM-1) or intercellular adhesion molecule-1 (ICAM-1))
9. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders
10. Adhesive protein receptors on hematopoietic cells
11. Adhesion molecules in inflammatory bowel disease
12. Recent developments in the immunology of inflammatory bowel disease
13. Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease
14. Intestinal inflammation in adhesion molecule-deficient mice: An assessment of P-selectin alone and in combination with ICAM-1 or E-selectin
15. Immunotherapy of inflammatory bowel diseases: Current concepts and future perspectives
16. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-KB abrogates established experimental colitis in mice
17. CEA adhesion molecules: Multifunctional proteins with signal-regulatory properties
18. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis and arthritis in HLA-B27/human β2 microglobulin transgenic rats
19. VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis
20. Cytokines in intestinal inflammation: Pathophysiological and clinical considerations
21. Development of an oral formulation for ICAM-1 antisense oligonucleotides
22. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats
23. Changed colonic profile of P-selectin, platelet-endothelial cell adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), ICAM-2 and ICAM-3 in inflammatory bowel disease
24. Antibodies to intercellular adhesion molecule-1 ameliorate the inflammatory response in acetic acid-induced inflammatory bowel disease
25. A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease
26. Crohn's disease, ulcerative colitis and normal intestinal lymphocytes express integrins in dissimilar patterns
27. A comparative analysis of two models of colitis in rats
28. Role of P-selectin and intercellular adhesion molecule-1 in TNB-induced colitis in rats