An adenosine A2A agonist, ATL-146e, reduces paralysis and apoptosis during rabbit spinal cord reperfusion

Journal of Vascular Surgery

Volumn 34, Issue 3, 2001, Pages 482-488

  Cassada, David C ^b   Tribble, Curtis G ^b   Laubach, Victor E ^b   Nguyen, Bao Ngoc ^b   Rieger, Jayson M ^b   Linden, Joel ^b   Kaza, Aditya K ^b   Long, Stewart M ^b   Kron, Irving L ^b   Kern, John A ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 [6 AMINO 9 (5 ETHYLCARBAMOYL 3,4 DIHYDROXYTETRAHYDRO 2 FURYL) 9H PURIN 2 YL] 2 PROPYNYL]CYCLOHEXANECARBOXYLIC ACID METHYL ESTER; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; PURINE DERIVATIVE;

ANIMAL; APOPTOSIS; ARTICLE; DRUG EFFECT; DRUG POTENTIATION; ISCHEMIA; PARALYSIS; RABBIT; REPERFUSION; SPINAL CORD; VASCULARIZATION;

ANIMALS; APOPTOSIS; CYCLOHEXANECARBOXYLIC ACIDS; ISCHEMIA; PARALYSIS; PURINES; RABBITS; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; REPERFUSION; SPINAL CORD;

EID: 0035463187     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1067/mva.2001.117996     Document Type: Article

References (30)

1. Cox GS, O'Hara PJ, Hertzer NR, Piedmonte MR, Krajewski LP, Beven EG. Thoracoabdominal aneurysm repair: a representative experience. J Vasc Surg 1992;15:780-7.
2. Crawford ES, Crawford JL, Sari HJ, Coselli JS, Hess KR, Brooks B, et al. Thoracoabdominal aortic aneurysms: preoperative and intraoperative factors determining immediate and long-term results of operations in 605 patients. J Vasc Surg 1986;3:389-404.
3. Ross SD, Kron IL, Parrino PE, Shockey KS, Kern JA, Tribble CG. Preservation of intercostal arteries during thoracoabdominal aortic aneurysm surgery: a retrospective study. J Thorac Cardiovasc Surg 1999;118:17-25.
4. Frank SM, Parker SD, Rock P, Gorman RB, Kelly S, Beattie C, et al. Moderate hypothermia, with partial bypass and segmental sequential repair for thoracoabdominal aortic aneurysm. J Vasc Surg 1994;19: 687-97.
5. Herold JA, Kron IL, Langenburg SE, Blackbourne LH, Tribble CG. Complete prevention of postischemic spinal cord injury by means of regional infusion with hypothermie saline and adenosine. J Thorac Cardiovasc Surg 1994;107:536-41.
6. Berguer R, Porto J, Fedoronko B, Dragovic L. Selective deep hypothermia of the spinal cord prevents paraplegia after aortic cross-clamping in the dog model. J Vasc Surg 1992;15:62-71.
7. Laschinger JC, Cunningham JN Jr, Cooper MM, Krieger K, Nathan IM, Spencer FC. Prevention of ischemic spinal cord injury following aortic cross-clamping: use of corticosteroids. Ann Thorac Surg 1984;38:500-7.
8. Kanellopoulos GK, Kato H, Wu Y, Dougenis D, Mackey M, Hsu CY, et al. Neuronal cell death in the ischemic spinal cord: the effect of methylprednisolone. Ann Thorac Surg 1997;64:1279-85.
9. Parrino PE, Kron IL, Ross SD, Shockey KS, Fisher MJ, Gaughen JR Jr, et al. Spinal cord protection during aortic cross-clamping using retrograde venous perfusion. Ann Thorac Surg 1999;67:1589-94.
10. Santicioli P, Delbiancho E, Maggi C. Adenosine Al receptors mediate the presynaptic inhibition of calcitonin gene-related peptide release by adenosine in the rat spinal cord. Eur J Pharmacol 1993;231:139-42.
11. Lukacova N. The relevance of ischemic preconditioning and tolerance in the neuroprotectivity of ischemia-induced neuronal damage: an up-to-date review. Biologia 1999;54:29-34.
12. Sakurai M, Hayashi T, Abe K, Aoki M, Sadahiro M, Tabayashi K. Enhancement of heat shock protein expression after transient ischemia in the preconditioned spinal cord of rabbits. J Vasc Surg 1998;27:720-5.
13. Matsumoto M, Ohtake K, Wakamatsu H, Oka S, Kiyoshima T, Nakakimura K, et al. The time course of acquisition of ischemic tolerance and induction of heat shock protein 70 after a brief period of ischemia in the spinal cord in rabbits. Anesth Analg 2001;92: 418-23.
14. States B, Honkaniemi J, Weinstein P, Sharp F. DNA fragmentation and HSP 70 protein induction in hippocampus and cortex occurs in separate neurons following permanent middle cerebral artery occlusion. J Cereb Blood flow Metab 1996;16:1165-75.
15. Leong KG, Karsan A. Signaling pathways mediated by tumor necrosis factor alpha [in process citation]. Histol Histopathol 2000;15:1303-25.
16. Chol Ha H, Snyder S, Poly(ADP-ribose) Polymerase-1 in the nervous system. Neurobiol Dis 2000;7:225-39.
17. Shackelford DA, Tobaru T, Zhang S, Zivin JA. Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion. J Neurosci 1999;19:4727-38.
18. Okusa MD, Linden J, Huang L, Rieger JM, Macdonald TL, Huynh LP. A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion. Am J Physiol Renal Physiol 2000;279:F809-18.
19. Rieger JM, Brown ML, Sullivan GW, Linden J, Macdonald TL. Design, synthesis, and evaluation of novel adenosine A2A receptor agonists. J Med Chem 2001;44:531-9.
20. Sullivan GW, Rieger JM, Scheld WM, Macdonald TL, Llnden J. Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A2A receptor agonists. Br J Pharmcol 2001;132:1017-26.
21. Ross SD, Kern JA, Gangemi JJ, St Laurent CR, Shockey KS, Kron IL, et al. Hypothermie retrograde venous perfusion with adenosine cools the spinal cord and reduces the risk of paraplegia after thoracic aortic clamping. J Thorac Cardiovasc Surg 2000;119:588-95.
22. Liang BT, Jacobson KA. A physiological role of the adenosine A3 receptor: sustained cardioprotection. Proc Natl Acad Sci U S A 1998;95:6995-9.
23. Jordan JE, Zhao ZQ, Sato H, Taft S, Vinten-Johansen J. Adenosine A2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence. J Pharmacol Exp Ther 1997;280:301-9.
24. Cassada D, Tribble C, Gangemi J, Kaza A, Long S, Rieger J, et al. Adenosine agonist reduces spinal cord reperfusion injury in a time dependent fashion. Surgery. In press 2001.
25. Chen J, Simon R. Ischemic tolerance in the brain. Neurology 1997;48:306-11.
26. de Haan P, Vanicky I, Jacobs MJ, Bakker O, Lips J, Meylaerts SA, et al. Effect of ischemic pretreatment on heat shock protein 72, neurologic outcome, and histopathologic outcome in a rabbit model of spinal cord ischemia. J Thorac Cardiovasc Surg 2000;120:513-9.
27. Kouchoukos NT, Rokkas CK. Regarding "observations on delayed neurologic deficit after thoracoabdominai aortic aneurysm." J Vasc Surg 1998;27:389-92.
28. Sakurai M, Hayashi T, Abe K, Sadahiro M, Tabayashi K. Delayed and selective motor neuron death after transient spinal cord ischemia: a role of apoptosis? [see comments]. J Thorac Cardiovasc Surg 1998;115: 1310-5.
29. Hasko G, Kuhel DG, Chen JF, Schwarzschild MA, Deitch EA, Mabley JG, et al. Adenosine inhibits IL-12 and TNF-alpha production via adenosine A2a receptor-dependent and independent mechanisms [in process citation]. FASEB J 2000;14:2065-74.
30. Sakurai M, Hayashi T, Abe K, Sadahiro M, Tabayashi K. Delayed selective motor neuron death and fas antigen induction after spinal cord ischemia in rabbits. Brain Res 1998;797:23-8.