Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: Implications for enzymic activity

Biochemical Journal

Volumn 366, Issue 2, 2002, Pages 399-404

  Lanone, Sophie ^a   Manivet, Philippe ^a   Callebert, Jacques ^a   Launay, Jean Marie ^a   Payen, Didier ^a   Aubier, Michel ^a   Boczkowski, Jorge ^a   Mebazaa, Alexandre ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

Author keywords

Peroxynitrite; Sepsis; Tyrosine nitration

Indexed keywords

MUSCULOSKELETAL SYSTEM; NITROGEN OXIDES; PATIENT MONITORING;

VIVO MODULATION;

ENZYMES;

NITRIC OXIDE SYNTHASE; PEROXYNITRITE; TYROSINE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NITRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; SEPSIS; SKELETAL MUSCLE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; NITRATES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS; SEPSIS; SPODOPTERA; TRANSFECTION; TYROSINE;

EID: 0036712607     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020339     Document Type: Article

References (27)

1. Nitric oxide in asthma. Pathogenic, therapeutic, or diagnostic?
2. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis
3. Expression of inducible nitric oxide synthase in failing and non-failing human heart
4. Inducible NO synthase II and neuronal NO synthase I are constitutively expressed in different structures of guinea pig skeletal muscle: Implications for contractile function
5. Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia
6. Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy
7. Nitration and inactivation of tyrosine hydroxylase by peroxynitrite
8. Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine
9. Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite
10. Muscular contractile failure in septic patients. Role of inducible nitric oxide synthase pathway
11. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways
12. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum
13. Sepsis is associated with reciprocal expressional modifications of constitutive nitric oxide synthase (NOS) in human skeletal muscle: Down-regulation of NOS1 and up-regulation of NOS3
14. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
15. Analysis of peptides and proteins containing nitrotyrosine by matrix-assisted laser desorption/ionization mass spectrometry
16. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate
17. Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation
18. CHARMM: A program for macromolecular energy, minimization and dynamics calculations
19. Factors determining the selectivity of protein tyrosine nitration
20. Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-L.
21. Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicity
22. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
23. Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders
24. Superoxide and peroxinitrite generation from inducible nitric oxide synthase in macrophages
25. Metabolic response to injury and sepsis: Changes in protein metabolism
26. Inactivation of the inducible nitric oxide synthase by peroxynitrite
27. Tyrosine phosphorylation of inducible nitric oxide synthase: Implications for potential post-translational regulation