Intracerebroventricular administration of missense oligodeoxynucleotide induces interleukin-6 mRNA expression in brain and spleen of rats

Neuroscience Letters

Volumn 217, Issue 2-3, 1996, Pages 97-100

  Pezeshki, Gita ^a   Schöbitz, Bernd ^a   Pohl, Thomas ^a   Reul, Johannes M H M ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Interleukin 6 mRNA; Intracerebroventricular injection; Missense oligodeoxynucleotide

Indexed keywords

CORTICOSTERONE; CYTOKINE; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; FEVER; GENE EXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN;

EID: 0030592537     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)13068-8     Document Type: Article

References (22)

1. [1] Brakkee, J.H., Wiegant, V.M. and Gispen, W.H., A simple technique for rapid implantation of a permenant cannula into the rat brain ventricular system, Lab. Animal Sci., 29 (1979) 78-81.
2. [2] Chomczynski, P. and Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem., 162 (1987) 156-159.
3. [3] Damas, P., Ledoux, D., Nys, M., Vrindts, Y., de Groote, D., Franchimont, P. and Lamy, M., Cytokine serum level during severe sepsis in human IL-6 as a marker of severity, Ann. Surg., 215 (1992) 356-362.
4. [4] De Simoni, M.G., Del Bo, R., De Luigi, A., Simard, S. and Forloni, G., Central endotoxin induces different patterns of interleukin (IL)-1β(3 and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery, Endocrinology, 136 (1995) 897-902.
5. [5] Hack, C.E., De Groot, E.R. and Felt-Bersma, R.J., F, Nuijens, J.H., Strack Van Schijndel, R.J.M., Eerenberg-Belmer, A.J.M., Thijs, L.G. and Aarden, L.A., Increased plasma levels of interleukin-6 in sepsis, Blood, 74 (1989) 1704-1710.
6. [6] Hélène, C. and Toulmé, J.J., Specific regulation of gene expression by antisense, sense and antigene nucleic acids, Biochim. Biophys. Acta, 1049 (1990) 99-125.
7. [7] Helle, M., Boeiji, L. and Aarden, L.A., Functional discrimination between interleukin 6 and interleukin 1, Eur. J. Immunol., 18 (1988) 1535-1540.
8. [8] Landgraf, R., Gerstberger, R., Montkowski, A., Probst, J.C., Wotjak, C.T., Holsboer, F. and Engelmann, M., V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats, J. Neurosci., 15 (1995) 4250-4258.
9. [9] Linthorst, A.C.E., Flachskamm, C., Holsboer, F. and Reul, J.M.H.M., Intraperitoneal administration of bacterial endotoxin enhances noradrenergic neurotranmission in the rat preoptic area: relationship with body temperature and hypothalamic-pituitary-adrenocortical axis activity, Eur. J. Neurosci., 7 (1995) 2418-2430.
10. [10] Muramami, N., Fukata, J., Tsukada, T., Kobayashi, H., Ebisui, O., Segawa, H., Muro, S., Imura, H. and Nakao, K., Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic acid in the rat hypothalamus, pituitary, adrenal gland, and spleen, Endocrinology, 133 (1993) 2574-2578.
11. [11] Neckers, L. and Whitesell, L., Antisense technology: biological utility and practical considerations, Am. J. Physiol., 265 (1993) L1-L12.
12. [12] Nijsten, M.W.N., de Groot, E.R., ten Dius, H.J., Klasen, H.J., Hack, C.E. and Aarden, L.A., Serum levels of interleukin-6 and acute phase responses, Lancet, 2 (1987) 921.
13. [13] Northmann, W., Braciak, T.A., Hattori, M. and Fey, G.H., Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells, J. Biol. Chem., 264 (1989) 16072-16082.
14. [14] Pezeshki, G., Pohl, T. and Schöbitz, B., Corticosterone controls interleukin-1β expression and sickness behavior in the rat, J. Neuroendocrinol., 8 (1995) 129-135.
15. [15] Sambrook, J., Fritsch, E.F. and Maniatis, T., Molecular Cloning, A Laboratory Manual, Cold Spring Harbour Laboratory Press, Cold Spring, New York, 1989, pp. 7.39-7.52.
16. [16] Schöbitz, B., van den Dobbelsteen, M., Holsboer, F., Sutanto, W. and de Kloet, E.R., Regulation of interleukin 6 gene expression in rat, Endocrinology, 132 (1993) 1569-1576.
17. [17] Schöbitz, B., de Kloet, E.R., Sutanto, W. and Holsboer, F., Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain, Eur. J. Neurosci., 5 (1993) 1426-1435.
18. [18] Schöbitz, B., Reul, J.M.H.M. and Holsboer, F., The role of the hypothalamic-pituitary-adrenocortical system during inflammatory conditions, Crit. Rev. Neurobiol., 8 (1994) 263-291.
19. [19] Skutella, T., Criswell, H., Moy, S., Probst, J.C., Breese, G.R., Jirikowski, G.F. and Holsboer, F., Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat, NeuroReport, 5 (1994) 2181-2185.
20. [20] Waage, A., Kaufmann, C., Espevik, T. and Husby, G., Interleukin-6 in synovial fluid from patients with arthritis, Clin. Immunol. Immunopathol., 50 (1989) 394-398.
21. [21] Wahlestedt, C., Merlo Pich, E., Koob, G.F., Yee, F, and Heilig, M., Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotide, Science, 259 (1993) 528-531.
22. [22] Whitesell, L., Geselowitz, D., Chavany, C., Fahmy, B., Walbridge, S., Alger, J.R. and Neckers, L.M., Stability, clearance, and disposition of intraventricular administered oligodeoxynucleotides: implications of therapeutic application within the central nervous system, Proc. Natl. Acad. Sci. USA, 90 (1993) 4665-4669.