Interplay of ionic and structural heterogeneity on functional action potential duration gradients: Implications for arrhythmogenesis

Chaos

Volumn 12, Issue 3, 2002, Pages 819-828

  Sampson, Kevin J ^a   Henriquez, Craig S ^a  

^a Duke University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0036710728     PISSN: 10541500     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.1497735     Document Type: Article

References (36)

1. J. Hah and G.K. Moe, "Nonuniform recovery of excitability in ventricular muscle," Circ. Res. 14, 44 (1964).
2. M.A. Allessie, F.I.M. Bonke, and F.J.G. Schopman, "Circus movement in rabbit atria muscle as a mechanism of tachycardia," Circ. Res. 33, 54 (1973).
3. M.S. Spach, P.C. Dolber, and P.A.W. Anderson, "Multiple regional differences in cellular properties that regulate repolarization and contraction in the right atrium of adult and newborn dogs," Circ. Res. 65, 1594 (1989).
4. S. Sicouri and C. Antzelevitch, "Electrophysiologic characteristics of M cells in the canine left ventricular free wall," J. Cardiovasc. Electrophysiol. 6, 591 (1995).
5. R.W. Joyner, "Modulation of repolarization by electrotonic interactions," Jpn. Heart J. 27, 167 (1986).
6. M.D. Lesh, M. Pring, and J.F. Spear, "Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium: A computer modeling study," Circ. Res. 65, 1426 (1989).
7. C. Antzelevitch et al., "Influence of transmural repolarization gradients on the electro-physiology and pharmacology of ventricular myocardium. Cellular basis for the brugada and long-QT syndrome," Philos. Trans. R. Soc. London, Ser. A 359, 1201 (2001).
8. W.E. Cascio, T.A. Johnson, and L.S. Gettes, "Electrophysiologic changes in ischemic ventricular myocardium: I. Influence of ionic, metabolic, and energetic changes," J. Cardiovasc. Electrophysiol. 6, 1 (1995).
9. K.R. Laurita, S.D. Girouard, F.G. Akar, and D.S. Rosenbaum, "Modulated dispersion explains changes in arrhythmia volnerability during premature stimulation of the heart," Circulation 98, 2774 (1998).
10. Ks heterogeneity on action potential duration and its rate dependance: A simulation study," Circulation 99, 2466 (1999).
11. J.M. Pastore, S.D. Girouard, K.R. Laurita, F.G. Akar, and D.S. Rosenbaum, "Mechanism linking T-wave alternans to the genesis of cardiac fibrillation," Circulation 99, 1385 (1999).
12. Z. Qu, A. Garfinkel, P.-S. Chen, and J.N. Weiss, "Mechanisms of discordant alternans and induction of re-entry in simulated cardiac tissue," Circulation 102, 1664 (2000).
13. M.A. Watanabe, F. Fenton, S.J. Evans, H.M. Hastings, and A. Karma, "Mechanisms for discordant alternans," J. Cardiovasc. Electrophysiol. 12, 196 (2001).
14. M. Gotoh et al., "Anisotropic repolarization in ventricular tissue," Am. J. Physiol. 41, H107 (1997).
15. T. Osaka, I. Kodama, N. Tsuboi, J. Toyama, and K. Yamad, "Effects of activation sequence and anisotropic cellular geometry on the repolarization phase of action potential of dog ventricular muscle," Circulation 76, 226 (1987).
16. B.M. Steinhaus, K.W. Spitzer, and S. Isomura, "Action potential collision in heart tissue - Computer simulations and tissue experiment," IEEE Trans. Biomed. Eng. 32, 731 (1985).
17. K.J. Sampson and C.S. Henriquez, "Simulation and prediction of functional block in the presence of structural and ionic heterogeneity," Am. J. Physiol. 281, H2597 (2001).
18. K.R. Laurita and D.S. Rosenbaum, "Interdependence of modulated dispersion and tissue structure in the mechanism of unidirectional block," Circ. Res. 87, 922 (2000).
19. J.M. Pastore and D.S. Rosenbaum, "Role of structural barriers in the mechanism of alternans-induced re-entry," Circ. Res. 87, 1157 (2000).
20. Y. Wang and Y. Rudy, "Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism," Am. J. Physiol. 278, H1019 (2000).
21. M. Courtemanche, L. Glass, and J. Keener, "Instabilities of a propagating pulse in a ring of excitable media," Phys. Rev. Lett. 70, 2182 (1993).
22. V.G. Fast and A.G. Kléber, "Cardiac tissue geometry as a determinant of unidirectional conduction block: Assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model," Cardiovasc. Res. 29, 697 (1995).
23. P. Comtois and A. Vinet, "Curvature effects on activation speed and repolarization in an ionic model of cardiac myocytes," Phys. Rev. E 60, 4619 (1999).
24. M.S. Spach et al., "The discontinuous nature of propagation in normal canine cardiac muscle: Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents," Circ. Res. 48, 39 (1981).
25. F. Fenton and A. Karma, "Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation," Chaos 8, 20 (1998).
26. C.H. Luo and Y. Rudy, "A model of the ventricular cardiac action potential: Depolarization, repolarization and their interaction," Circ. Res. 68, 1501 (1991).
27. D.J. Rose, H. Shao, and C.S. Henriquez, "Discretization of anisotropic convection-diffusion equations, convective M-matrices and their iterative solution," VLSI Des. 10, 485 (2000).
28. R.C. Penland, D.M. Harrild, and C.S. Henriquez, "Modeling impulse propagation and extracellular potential distributions in anisotropic cardiac tissue using a finite volume element discretization," Comput. Vis. Sci. 4, 215 (2002).
29. J.B. Pormann, "A modular simulation system for the bidomain equations," Ph.D. thesis, Duke University, Durham, NC, 1999.
30. K.J. Sampson and C.S. Henriquez, "Impact of geometry on action potential duration (APD) dispersion in cardiac tissue (abstract only)," Ann. Biomed. Eng. 29, 52 (2001).
31. G.K. Moe, W.C. Rheinboldt, and J.A. Abildskov, "A computer model of atrial fibrillation," Am. Heart J. 67, 200 (1964).
32. A.T. Winfree, "Electrical instability in cardiac muscle: phase singularities and rotors," J. Theor. Biol. 138, 353 (1989).
33. A.T. Winfree, "Various ways to make phase singularities by electric shock," J. Cardiovasc. Electrophysiol. 11, 286 (2000).
34. A.M. Street and R. Plonsey, "Propagation in cardiac tissue adjacent to connective tissue: two-dimensional modeling studies," IEEE Trans. Biomed. Eng. 46, 19 (1999).
35. D.M. Harrild and C.S. Henriquez, "A finite volume model of cardiac propagation," Ann. Biomed. Eng. 25, 315 (1997).
36. D.M. Harrild, R.C. Penland, and C.S. Henriquez, "A flexible method for simulating cardiac conduction in three-dimensional complex geometries," J. Electrocardiol. 33, 241 (2000).