A neutral theory predicts multigenic aging and increased concentrations of deleterious mutations on the mitochondrial and Y chromosomes

Free Radical Biology and Medicine

Volumn 33, Issue 5, 2002, Pages 605-610

  Cortopassi, Gino A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fixation; Free radicals; Mitochondrial genome; Mutation; Population genetics

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

AGING; AUTOSOME; CELL NUCLEUS; CONCENTRATION (PARAMETERS); DNA SEQUENCE; GENE FREQUENCY; GENE FUNCTION; GENE MUTATION; GENE NUMBER; GENE TRANSFER; GENETIC TRAIT; GENOME SIZE; HUMAN; HUMAN GENOME; LIFESPAN; MITOCHONDRIAL GENETICS; MOLECULAR EVOLUTION; MUTATION; POPULATION GENETICS; POPULATION SIZE; PREDICTION; PRIORITY JOURNAL; RECOMBINANT GENE; REVIEW; SOMATIC MUTATION; THEORY; Y CHROMOSOME;

ANETHUM GRAVEOLENS;

EID: 0036709813     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00966-8     Document Type: Article

References (29)

1. Fristrom J.W., Spieth P.T. Principles of genetics. 1980;Chiron Press, New York.
2. Fisher R.A. The genetical theory of natural selection. 1930;Oxford University Press, Oxford, UK.
3. Medawar P.B. Old age and natural death. Mech. Dev. 1:1946;30-56.
4. Medawar P.B. An unsolved problem of biology. 1952;H. K. Lewis, London.
5. Williams G.C. Pleiotropy, natural selection, and the evolution of senescence. Evolution. 11:1957;398-411.
6. Hamilton W.D. The moulding of senescence by natural selection. J. Theor. Biol. 12:1966;12-45.
7. Charlesworth B. Evolution in age-structured populations. 1994;Cambridge University Press, Cambridge, UK.
8. Charlesworth B. Fisher, Medawar, Hamilton and the evolution of aging. Genetics. 156:2000;927-931.
9. Horai S., Satta Y., Hayasaka K., Kondo R., Inoue T., Ishida T., Hayashi S., Takahata N. Man's place in Hominoidea revealed by mitochondrial DNA genealogy. J. Mol. Evol. 35:1992;32-43.
10. Cann R.L., Stoneking M., Wilson A.C. Mitochondrial DNA and human evolution. Nature. 325:1987;31-36.
11. Rose M.R. The evolutionary biology of aging. 1991;Oxford University Press, Oxford, UK.
12. Cortopassi G.A. Fixation of deleterious alleles, evolution, and human aging. Mech. Aging Dev. 123:2002;851-855.
13. Muller H.J. The relation of recombination to mutational advance. Mutat. Res. 1:1964;2-9.
14. Charlesworth B., Charlesworth D. The degeneration of Y chromosomes. Phil. Trans. R. Soc. Lond. B355:2000;1563-1572.
15. Jenuth J.P., Perterson A.C., Fu K., Shoubridge E.A. Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA. Nat. Genet. 14:1996;146-151.
16. Howell N., Ghosh S.S., Fahy E., Bindoff L.A. Longitudinal analysis of the segregation of mtDNA mutations in heteroplasmic individuals. J. Neurol. Sci. 172:2000;1-6.
17. Lynch M. Mutation accumulation in transfer RNAs molecular evidence for Muller's ratchet in mitochondrial genomes . Mol. Biol. Evol. 13:(1):1996;209-220.
18. Lynch M. Mutation accumulation in nuclear, organelle, and prokaryotic transfer RNA genes. Mol. Biol. Evol. 14:1997;914-925.
19. Moran N.A. Acelerated evolution and Muller's rachet in endosymbiotic bacteria. Proc. Natl. Acad. Sci. USA. 93:1996;2873-2878.
20. Wernegreen J.J., Moran N.A. Evidence for genetic drift in endosymbionts (Buchnera) analyses of protein-coding genes . Mol. Biol. Evol. 16:1999;83-97.
21. Brown W.M., George M. Jr, Wilson A.C. Rapid evolution of animal mitochondrial DNA. Proc. Natl. Acad. Sci. USA. 76:1979;1967-1971.
22. Enriquez J.A., Chomyn A., Attardi G. MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNA(Lys) and premature translation termination. Nat. Genet. 10:1995;47-55.
23. Schon E.A., Rizzuto R., Moraes C.T., Nakase H., Zeviani M., DiMauro S. A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA. Science. 244:1989;346-349.
24. Cortopassi G.A., Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucl. Acids Res. 18:1990;6927-6933.
25. Brierley E.J., Johnson M.A., Lightowlers R.N., James O.F., Turnbull D.M. Role of mitochondrial DNA mutations in human aging implications for the central nervous system and muscle . Ann. Neurol. 43:1998;217-223.
26. Johnston W., Karpati G., Carpenter S., Arnold D., Shoubridge E.A. Late-onset mitochondrial myopathy. Ann. Neurol. 37:1995;16-23.
27. Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 273:1996;59-63.
28. Wong A., Cavelier L., Collins-Schramm H.E., Seldin M.F., McGrogan M., Savontaus M.-L., Cortopassi G.A. Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells. Hum. Mol. Genet. 11:2002;1-8.
29. Geromel V., Kadhom N., Cebalos-Picot I., Ouari O., Polidori A., Munnich A., Rotig A., Rustin P. Superoxide-induced massive apoptosis in cultured skin fibroblasts harboring the neurogenic ataxia retinitis pigmentosa (NARP) mutation in the ATPase-6 gene of the mitochondrial DNA. Hum. Mol. Genet. 15:2001;1221-1228.