HSP90α, HSP90β, and p53 expression following in vitro hyperthermia exposure in gestation day 10 rat embryos

Toxicological Sciences

Volumn 69, Issue 1, 2002, Pages 183-190

  Dugyala, Raviprakash R ^a,d   Claggett, Thomas W ^a   Kimmel, Gary L ^b,c   Kimmel, Carole A ^b,c  

^a CHARLES RIVER LABORATORIES   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Developmental toxicity; HSP90; Hyperthermia; p53; Rat embryo culture

Indexed keywords

FORMALDEHYDE; HEAT SHOCK PROTEIN 90; PARAFFIN; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; GESTATIONAL AGE; HYPERTHERMIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAMMAL; MESODERM; NEURAL TUBE; NEUROEPITHELIUM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SOMITE; TEMPERATURE; THERMAL EXPOSURE; TIME; TISSUE SECTION; ANIMAL; BIOSYNTHESIS; CYTOLOGY; FEMALE; FEVER; GENE EXPRESSION REGULATION; GENETICS; HEAT; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT; TUMOR SUPPRESSOR GENE;

ANIMALIA; MAMMALIA;

ANIMALS; EMBRYO; FEMALE; FEVER; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, P53; HEAT; HSP90 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; ORGAN CULTURE TECHNIQUES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036708568     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.1.183     Document Type: Article

References (36)

1. Aligue, R., Akhavan-Niak, H., and Russell, P. (1994). A role for HSP90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with HSP90. EMBO J. 13, 6099-6106.
2. Almog, N., and Rotter, V. (1997). Involvement of p53 in cell differentiation and development. Biochim. Biophys. Acta 1333, F1-F27.
3. Blagosklonny, M. V., Toretsky, J., Bohen, S., and Neckers, L. (1996). Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90. Proc. Natl. Acad. Sci. U.S.A. 93, 8379-8383.
4. Bolaris, S., Bozas, E., Benekou, A., Philippidis, H., and Stylianopoulou, F. (2001). In utero radiation-induced apoptosis and p53 gene expression in the developing rat brain. Int. J. Radiat. Biol. 77, 71-81.
5. Breen, J. G., Claggett, T. W., Kimmel, G. L., and Kimmel, C. A. (1999). Heat shock during rat embryo development in vitro results in decreased mitosis and abundant cell death. Rep. Toxicol. 13, 31-39.
6. Craig, E. A., Weissman, J. S., and Horwich. A. L. (1994). Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell. Cell 78, 365-372.
7. Cuff, J. M., Kimmel, G. L., Kimmel, C. A., Heredia, D. J., Tudor, N., and Chen, J. (1993). The relationship between abnormal somite development and thoracic skeletal defects in rats following heat exposure. Teratology 48, 259-266.
8. Dasgupta, G., and Momand, J. (1997). Geldanamycin prevents nuclear translocation of mutant p53. Exp. Cell Res. 237, 29-37.
9. Edwards, M. J. (1971). The experimental production of clubfoot in guinea-pigs by maternal hyperthermia during gestation. J. Pathol. 103, 49-53.
10. Edwards, M. J., Walsh, D. A., and Li, Z. (1997). Hyperthermia, teratogenesis and the heat shock response in mammalian embryos in culture. Int. J. Dev. Biol. 41, 345-358.
11. Graham, J. M., Edwards, M. J., and Edwards, M. J. (1998). Teratogen update: Gestational effects of maternal hyperthermia due to febrile illness and resultant patterns of defects in humans. Teratology 58, 209-221.
12. Hainaut, P., Butcher, S., and Milner, J. (1995). Temperature sensitivity for conformation is an intrinsic property of wild-type p53. Br. J. Cancer 71, 227-231.
13. Hoever, M., Clement, J. H., Wedlich, D., Montenarh, M., and Knochel, W. (1994). Overexpression of wild-type p53 interferes with normal development in xenopus laevis embryos. Oncogene 9, 109-120.
14. Kapron-Bras, C. M., and Hales, B. F. (1991). Heat-shock induced tolerance to the embryotoxic effects of hyperthermia and cadmium in mouse embryos in vitro. Teratology 43, 83-94.
15. Kimmel, C. A., Cuff, J. M., Kimmel, G. L., Heredia, D. J., Tudor, N., Silverman, P. M., and Chen, J. (1993a). Skeletal development following heat exposure in the rat. Teratology 47, 229-242.
16. Kimmel, G. L., Cuff, J. M., Kimmel, C. A., Heredia, D. J., Tudor, N., and Silverman, P. M. (1993b). Embryonic development in vitro following short-duration exposure to heat. Teratology 47, 243-251.
17. Krone, P. H., and Sass, J. B. (1994). HSP 90α and HSP 90β genes are present in the zebrafish and are differentially regulated in developing embryos. Biochem. Biophys. Res. Commun. 204, 746-752.
18. Mirkes, P. E. (1985). Effects of acute exposure to elevated temperatures on rat embryo growth and development in vitro. Teratology 32, 259-266.
19. Mirkes, P. E. (1987). Hyperthermia-induced heat shock response and thermotolerance in postimplantation rat embryos. Dev. Biol. 119, 115-122.
20. Mirkes, P. E., Cornel, L. M., Park, H. W., and Cunningham, M. L. (1997). Induction of thermotolerance in early postimplantation rat embryos is associated with increased resistance to hyperthermia-induced apoptosis. Teratology 56, 210-219.
21. Moore, S. K., Kozak, C., Robinson, E. A., Ullrich, S. J., Appella, E. (1989). Murine 86- and 84-kDa heat shock proteins, cDNA sequences, chromosome assignments, and evolutionary origins. J. Biol. Chem. 264, 5343-5351.
22. Nakamura, T., Pichel, J. G., Williams-Simons, L., Westphal, H. (1995). An apoptic defect in lens differentiation caused by human p53 is rescued by a mutant allele. Proc. Natl. Acad. Sci. U.S.A. 92, 6142-6146.
23. Nilsen, N. O. (1984). Vascular abnormalities due to hyperthermia in chick embryos. Teratology 30, 237-251.
24. Ohnishi, T., Matsumoto, H., Takahashi, A., Shimura, M., and Majima, H. J. (1995). Accumulation of mutant p53 and HSP72 by heat treatment, and their association in a human glioblastoma cell line. Int. J. Hyperthermia 11, 663-671.
25. Pratt, W. B. (1998). The HSP90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors. Proc. Soc. Exp. Biol. Med. 217, 420-434.
26. Rebbe, N. F., Hickman, W. S., Ley, T. J., Stafford, D. W., and Hickman, S. (1989). Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. J. Biol. Chem. 264, 15006-15011.
27. Richter, K., and Buchner, J. (2001). HSP90: Chaperoning signal transduction. J. Cell. Physiol. 188, 281-290.
28. Sass, J. B., and Krone, P. H. (1997). HSP90 gene expression may be a conserved feature of vertebrate somitogenesis. Exp. Cell Res. 233, 391-394.
29. Sah, V. P., Attardi, L. D., Mulligan, G. J., Williams, B. O., Bronson, R. T., and Jacks, T. (1995). A subset of p53-deficient embryos exhibit exencephaly. Nature Genet. 10, 175-180.
30. Selkirk, J. K., Merrick, B. A., Stackhouse, B. L., He, C. (1994). Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins HSP70 and HSP90 in the human mammary tumor, T47D, cell line. Appl. Theor. Electrophor. 4, 11-18.
31. Walsh, D. A., Klein, N. W., Hightower, L. E., and Edwards, M. J. (1987). Heat shock and thermotolerance during early rat embryo development. Teratology 36, 181-191.
32. Walsh, D., Li, K., Wass, J., Dolnikov, A., Zeng, F., Zhe, L., and Edwards, M. (1993). Heat-shock gene expression and cell cycle changes during mammalian embryonic development. Dev. Genet. 14, 127-136.
33. Walsh, D. A., Li, K., Wass, J., Dolnikov, A., Zeng, F., Yan, W., and Edwards, M. J. (1994). Heat shock genes and cell cycle regulation during early mammalian development. Environ. Med. 38, 1-6.
34. Whitesell, L., Sutphin, P. D., Pulcini, E. J., Martinez, J. D., and Cook, P. H. (1998). The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an HSP90-binding agent. Mol. Cell. Biol. 18, 1517-1524.
35. Wilkinson, J. M., and Pollard, I. (1993). Immunohistochemical localisation of the 90, 70, and 25 kDa heat shock proteins in control and caffeine treated rat embryos. Anat. Anz. 175, 561-566.
36. Wubah, J. A., Ibrahim, M. M., Gao, X., Nguyen, D., Pisano, M. M., and Knudsen, T. B. (1996). Teratogen-induced eye defects mediated by p53-dependent apoptosis. Curr. Biol. 6, 60-69.