Liver glutathione concentrations in dogs and cats with naturally occurring liver disease

American Journal of Veterinary Research

Volumn 63, Issue 8, 2002, Pages 1187-1197

  Center, Sharon A ^a   Warner, Karen L ^a   Erb, Hollis N ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIVER PROTEIN; PYRIDINE DERIVATIVE;

AGED; ANIMAL TISSUE; ARTICLE; CAT; CONTROLLED STUDY; DOG; ENZYME ASSAY; EXTRAHEPATIC BILE DUCT OBSTRUCTION; FEMALE; HEPATITIS; LIPIDOSIS; LIVER BIOPSY; LIVER DISEASE; LIVER LEVEL; LIVER NECROSIS; LIVER SARCOMA; LIVER WEIGHT; LYMPHOSARCOMA; MALE; NONHUMAN; PROTEIN ANALYSIS; TISSUE LEVEL; VASCULAR DISEASE;

ANIMALIA; CANIS FAMILIARIS; FELIDAE; FELIS CATUS;

EID: 0036702090     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2002.63.1187     Document Type: Article

References (60)

1. Deleve LD, Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 1991;52:287-305.
2. Deneke SM, Fanburg BL. Regulation of cellular glutathione. Am J Physiol 1989;257:L163-L173.
3. Anderson ME, Meister A. Dynamic state of glutathione in blood plasma. J Biol Chem 1980;255:9530-9533.
4. Lauterberg BH, Smith CV, Mitchell JR. Regulation of hepatic glutathione homeostasis. In: JR Mitchell, MG Horning, eds. Drug metabolism and drug toxicity. New York: Raven Press, 1984;321-330.
5. Tribble DL, Aw TK, Jones DP. The pathophysiological significance of lipid peroxidation in oxidative cell injury. Hepatology 1987;7:377-386.
6. Losser M-R, Payen D. Mechanisms of liver damage. Semin Liver Dis 1996;16:356-367.
7. Paradis V, Kollinger M, Fabre M, et al. In situ detection of lipid peroxidation by-products in chronic liver diseases. Hepatology 1997;26:135-142.
8. Poulsen HE, Ranek L, Andreasen PB. The hepatic glutathione content in liver disease. Scand J Clin Lab Invest 1981;41:573-576.
9. Sieger CP, Bossen KH, Younes M, et al. Glutathione and glutathione-S-transferases in the normal and diseased human liver. Pharmacol Res Commun 1982;14:61-72.
10. Videla LA, Iturriaga H, Pino ME, et al. Content of hepatic reduced glutathione in chronic alcoholic patients: influence of the length of abstinence and liver necrosis. Clin Sci 1984;66:283-290.
11. Jewell SA, Di Monte D, Gentile A, et al. Decreased hepatic glutathione in chronic alcoholic patients. J Hepatol 1986;3:1-6.
12. Lauterburg BH, Velez ME. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988;29:1153-1157.
13. Vendemiale G, Altomare E, Trizio T, et al. Effects of oral s-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol 1989;24:407-415.
14. Mato JM, Corrales F, Martin-Duce A, et al. Mechanisms and consequences of the impaired trans-sulfuration pathway in liver disease: part 1. Drugs 1990;40:58-64.
15. Pisi E, Marchesini G. Mechanisms and consequences of the impaired trans-sulfuration pathway in liver disease: part II. Clinical consequences and potential for pharmacological intervention in cirrhosis. Drugs 1990;40:65-72.
16. Cabrero C, Martin Duce A, Ortiz P, et al. Specific loss of the high-melecular-weight form of s-adenosyl-L-methionine synthetase in human liver cirrhosis. Hepatology 1988;88:1530-1534.
17. Duce AM, Ortiz P, Cabrero C, et al. S-Adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 1988;8:65-68.
18. Griffth OW. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 1980;106:207-212.
19. Susuki H, Robinson MK, Rounds JD, et al. Glutathione deficiency accentuates hepatocellular fluid accumulation after ischemia-reperfusion. J Surg Res 1994;57:632-639.
20. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
21. Down TR, Wilfinger WW. Fluorometric quantification of DNA in cells and tissue. Anal Biochem 1983;131:538-547.
22. Tietze F. Enzyme method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969;27:502-521.
23. Hissin PJ, Hill R. A fluorormetric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976;74:214-226.
24. Nakano H, Boudjema K, Alexandre E, et al. Protective effects of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver. Hepatology 1995;22:539-545.
25. Slivka A, Spina MB, Cohen G. Reduced and oxidized glutathione in human and monkey brain. Neurosci Lett 1987;74:112-118.
26. Mourad T, Min K-L, Steghens J-P. Measurement of oxidized glutathione by enzymatic recycling coupled to bioluminescent detection. Anal Biochem 2000;283:146-152.
27. Park Y, Smith RD, Combs AB, et al. Prevention of acetaminophen-induced hepatotoxicity by dimethyl sulfoxide. Toxicology 1988;52:165-175.
28. Harding CO, Williams P, Wagner E, et al. Mice with genetic g-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility. J Biol Chem 1997; 272:12560-12567.
29. Will Y, Fischer KA, Horton RA, et al. Glutamy-Itranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function. Hepatology 2000;32:740-749.
30. Adachi T, Yasutake A, Hirayama K. Influence of dietary protein levels on the fate of methylmercury and glutathione metabolism in mice. Toxicology 1992;72:17-26.
31. Hjelle JJ, Brzeznicka EA, Klaassen CD. Comparison of the effects of sodium sulfate and n-acetylcysteine on the hepatotoxicity of acetaminophen in mice. J Pharmacol Exp Ther 1986;236:526-534.
32. Gerard-Monnier D, Fougeat S, Chaudiere J. Glutathione and cysteine depletion in rats and mice following acute intoxication with diethylmaleate. Biochem Pharmacol 1992;43:451-456.
33. Wong BK, Chan HC, Corcoran GB. Selective effects of n-acetylcysteine stereoisomers on hepatic glutathione and plasma sulfate in mice. Toxicol Appl Pharmacol 1986;86:421-429.
34. Sastre J, Pallardo FV, Llopis J, et al. Glutathione depletion by hyperphagia-induced obesity. Life Sci 1989;45:183-187.
35. Hjelle JJ, Brzenznicha EA, Klaassen CD. Comparison of the effects of sodium sulfate an n-acetylcysteine on the hepatotoxicity of acetaminophen in mice. J Pharmacol Exp Ther 1986;236:526534.
36. Griffith OW, Meister A. Glutathione: interorgan translocation, turnover, and metabolism. Proc Natl Acad Sci U S A 1979;76:5606-5610.
37. Sies H, Brigelius R, Akerboom TPM. Intrahepatic glutathione status. In: Larsson A, Orrenius S, Holmgren A, eds. Functions of glutathione: biochemical, physiological, toxicological, and clinical aspects. New York: Raven Press, 1983;51-64.
38. Ortega L, Landa Garcia JI, Torres Garcia A, et al. Acetaminophen-induced fulminant hepatic failure in dogs. Hepatology 1985;5:673-676.
39. Francavilla A, Makowka L, Polimeno L, et al. A dog model for acetaminophen-induced fulminant hepatic failure. Gastroenterology 1989;96:470-478.
40. Kelly JH, Koussayer T, He DE, et al. An improved model of acetaminophen-induced fulminant hepatic failure in dogs. Hepatology 1992;15:329-335.
41. Lauterburg BH, Velez ME. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988;29:1153-1157.
42. Draganov P, Durrence H, Cox C, et al. Alcohol-acetaminophen syndrome. Even moderate social drinkers are at risk. Postgrad Med 2000;107:189-195.
43. Lieber CS. Alcoholic liver disease: new insights in pathogenesis lead to new treatments. J Hepatol 2000:32(suppl 1):113-128.
44. Lu SC. Methionine adensyltransferase and liver disease: its all about SAM. Gastroenterology 1998;114:403-407.
45. Horowitz JH, Rypins EB, Henderson JM, et al. Evidence for impairment of transsulfuration pathway in cirrhosis. Gastroenterology 1981;81:668-675.
46. Chawla RK, Bonkovsky, Galambo JT. Biochemistry and pharmacology of s-Adenosyl-L-Methionine and rationale for its use in liver disease. Drugs 1990;40:98-110.
47. Ookhtens M, Lyon I, Kaplowitz N. Effect of age on the sinusoidal release of hepatic glutathione from the perfused rat liver. Biochem Pharmacacol 1987;36:4015-4017.
48. Ookhtens M, Maddatu T. Mechanism of changes in hepatic sinusoidal and biliary glutathione efflux with age in the rat. Am J Physiol 1991;261:C648-G656.
49. Anderson ME. Enzymatic and chemical methods for determination of glutathione. In: Dolphin D, Poulson R, Avramovic O, eds. Glutathione: chemical, biochemical and medical aspects. Vol A. New York: John Wiley & Sons, 1989;339-365.
50. Griffith OW, Meister A. Origin and turnover of mitochondrial glutathione. Proc Natl Acad Sci U S A 1985;82:4668-4672.
51. Olafsdottir K, Reed DJ. Retention of oxidized glutathione by isolated rat liver mitochondria during hyperperoxide treatment. Biochim Biophys Acta 1988;964:377-382.
52. Hwang C, Sinskey AJ, Lodish HF. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 1992;257:1496-1502.
53. Wahllander A, Soboll S, Sies H. Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH s-tranferases. FEBS Lett 1979;97:138-140.
54. Meredith MJ, Reed DJ. Status of the mitochondrial pool of glutathione in the isolated hepatocyte. J Biol Chem 1982;257:3747-3753.
55. Smith MT, Loveridge N, Wills ED. The distribution of glutathione in the rat liver lobule. Biochem J 1979;182:103-108.
56. Penttila KE. Role of cysteine and taurine in regulating glutathione synthesis by periportal and perivenous hepatocytes. Biochem J 1990;269:659-664.
57. Kera Y, Penttila KE, Lindros KO. Glutathione replenishment capacity is lower in isolated perivenous than in peripheral hepatocytes. Biochem J 1988;254:411-417.
58. Lauterburg BH, Smith CV, Hughes H, et al. Biliary excretion of glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. J Clin Invest 1984;73:124-133.
59. Ookhtens M, Lyon I. Fernandez-Checa JC. et al. Inhibition of glutathione efflux in the perfured rat liver and isolated hepatocytes by organic anions and bilirubin: kinetics, sidedness, and molecular forms. J Clin Invest 1988;82:608-616.
60. Aw TY, Ookthens M, Kaplowitz N. Mechanisms of inhibition glutathione efflux by methionine from isolated rat hepatocytes. Am J Physiol 1986;251:G354-G361.