Quantitative structure-activity relationship study of 2-arylsulfonyl-6-substituted benzonitriles as non-nucleoside reverse. Transcriptase inhibitors of HIV-1

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 17, Issue 4, 2002, Pages 219-225

  Sharma, B K ^a   Kumar, Rajendra ^a   Singh, P ^a  

^a SK Government College   (India)

Author keywords

2 Arylsulfonyl 6 substituted benzonitriles; Fujita Ban and Hansch approaches; Non nucleoside reverse transcriptase inhibitors of HIV 1; Physicochemical properties; QSAR analysis

Indexed keywords

ANTIVIRUS AGENT; BENZONITRILE DERIVATIVE; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZONITRILE; NITRILE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECT; HUMAN; IC 50;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

ANTI-HIV AGENTS; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; NITRILES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 0036700501     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636021000010932     Document Type: Article

References (12)

1. Montaner, J.S.G., Reiss, P., Cooper, D., Vella, S., Harris, M., Conway, B., Wainberg, M.A., Smith, D., Robinson, P., Hall, D., Myers, M. and Lange, J.M.A. (1998) J. Am. Med. Assoc. 279, 930-937.
2. To date six nucleosides have been approved by the FDA: AZT, 3TC, d4T, ddI, ddC and abacavir.
3. Moeremans, M., Raeymaeker, M.D., Broeck, R.V.D., Stoffels, P., Brabander, M.E., Cree, J.D., Hertogs, K., Pauwels, R., Staszewski, S. and Andries, K. (1995) Abstract of the 4th International Workshop on HIV Drug Resistance, Sardinia, Italy, July 6-9, p. 33.
4. Freimuth, W.W. (1996) Adv. Exp. Med. Bio. 394, 279 -289.
5. Young, S.D., Britcher, S.F., Tran, L.O., Payne, L.S., Lumma, W.C., Lyle, T.A., Huff, J.R., Anderson, P.S., Olsen, D.B., Carroll, S.S., Pettibone, D.J., O'Brien, J.A., Ball, R.G., Balani, S.K., Lin, J.H., Chen, I.-W., Schleif, W.A., Sardana, V.V, Long, W.J., Byrnes, V.W. and Emini, E.A. (1995) Antimicrob. Agents Chemother. 39, 2602-2605.
6. Hogg, R.S., Rhone, S.A., Yip, B., Sherlock, C., Conway, B., Schechter, M.T., O'Shaughnessy, M.V. and Montaner, J.S.G. (1998) AIDS 12, 279-284.
7. Palella, Jr, F.J., Delaney, K.M., Moorman, A.C., Loveless, M.O., Fuhrer, J., Satten, G.A., Aschman, D.J. and Holmberg, S.D. (1998) N. Engl. J. Med. 338, 853-860.
8. Chan, J.H., Hong, J.S., Hunter, III, R.N., Orr, F., Cowan, J.R., Sherman, D.B., Sparks, S.M., Reitter, B.E., Andrews, III, C.W., Hazen, R.J., Clair, M.S., Boone, L.R., Ferris, R.G., Creech, K.L., Roberts, G.B., Short, S.A., Weaver, K., Ott, R.J., Ren, J., Hopkins, A., Stuart, D.I. and Stammers, D.K. (2001) J. Med. Chem. 44, 1866-1882.
9. Fujita, T. and Ban, T. (1971) J. Med. Chem. 14, 148-152.
10. Hansch, C. and Leo, A.J. (1979) Substituents Constants for Correlation Analysis in Chemistry and Biology (John Wiley, New York).
11. Snedecor, G.W. and Cochran, W.G. (1967) Statistical Methods. (Iowa State University Press, Ames).
12. Draper, N.R. and Smith, H. (1966) Applied Regression Analysis (Wiley, New York).