Immunohistochemical staining for c-Kit (CD117) is a rare event in human colorectal carcinoma

Clinical Colorectal Cancer

Volumn 2, Issue 2, 2002, Pages 119-122

  Reed, Jennifer ^a   Ouban, Abderrahman ^a   Schickor, Frank K ^b   Muraca, Patrick ^b   Yeatman, Timothy ^a,c   Coppola, Domenico ^a,c  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b Clinomics BioSciences Inc   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Adenocarcinoma; C Kit expression; Cloacogenic carcinoma; Imatinib mesylate; Tissue microarray

Indexed keywords

ANTINEOPLASTIC AGENT; AVIDIN; BIOTIN; DNA; FORMALDEHYDE; PARAFFIN; PEROXIDASE; POLYCLONAL ANTIBODY; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANUS; ARTICLE; AUTOCRINE EFFECT; CANCER GROWTH; CANCER PATIENT; CANCER STAGING; CANCER TISSUE; CLINICAL ARTICLE; COLON ADENOMA; COLON MUCOSA; COLORECTAL CARCINOMA; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CYTOPLASM; DNA MICROARRAY; DRUG RESPONSE; DRUG TARGETING; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCIDENCE; MALE; PROGNOSIS; RECTUM; REGULATORY MECHANISM; SCORING SYSTEM; SCREENING TEST; TUMOR DIFFERENTIATION;

EID: 0036696432     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2002.n.018     Document Type: Article

References (35)

1. Alexander WS, Lyman SD, Wagner EF. Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells. Embo J 1991; 10:3683-3691.
2. Matsui Y, Zsebo KM, Hogan BL. Embryonic expression of a haematopoietic growth factor encoded by the S1 locus and the ligand for c-kit. Nature 1990; 347:667-669.
3. Zsebo KM, Williams DA, Geissler EN, et al. Stem cell factor is encoded at the S1 locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 1990; 63:213-224.
4. Beck D, Gross N, Brognara CB, et al. Expression of stem cell factor and its receptor by human neuroblastoma cells and tumors. Blood 1995; 86:3132-3138.
5. Timeus F, Crescenzio N, Valle P, et al. Stem cell factor suppresses apoptosis in neuroblastoma cell lines. Exp Hematol 1997; 25:1253-1260.
6. Turner AM, Zsebo KM, Martin F, et al. Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors. Blood 1992; 80:374-381.
7. Hibi K, Takahashi T, Sekido Y, et al. Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer. Oncogene 1991; 6:2291-2296.
8. DiPaola RS, Kuczynski WI, Onodera K, et al. Evidence for a functional kit receptor in melanoma, breast, and lung carcinoma cells. Cancer Gene Ther 1997; 4:176-182.
9. Hines SJ, Litz JS, Krystal GW. Coexpression of c-kit and stem cell factor in breast cancer results in enhanced sensitivity to members of the EGF family of growth factors. Breast Cancer Res Treat 1999; 58:1-10.
10. Bellone G, Silvestri S, Artusio E, et al. Growth stimulation of colorectal carcinoma cells via the c-kit receptor is inhibited by TGF-beta 1. J Cell Physiol 1997; 172:1-11.
11. Simak R, Capodieci P, Cohen DW, et al. Expression of c-kit and kit-ligand in benign and malignant prostatic tissues. Histol Histopathol 2000; 15:365-374.
12. Ashman LK, Ferrao P, Cole SR, et al. Effects of mutant c-Kit in early myeloid cells. Leuk Lymphoma 1999; 34:451-461.
13. Bernex F, De Sepulveda P, Kress C, et al. Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos. Development 1996; 122:3023-3033.
14. Vannucchi MG. Receptors in interstitial cells of Cajal: identification and possible physiological roles. Microsc Res Tech 1999; 47:325-335.
15. Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998; 279:577-580.
16. Bellone G, Carbone A, Sibona N, et al. Aberrant activation of c-kit protects colon carcinoma cells against apoptosis and enhances their invasive potential. Cancer Res 2001; 61:2200-2206.
17. Terris B, Bralet MP. [Tissue microarrays, or the advent of chips in pathology]. Ann Pathol 2002; 22:69-72.
18. Allred DC, Clark GM, Elledge R, et al. Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst 1993; 85:200-206.
19. Beahrs OH, Henson DE, Hutter RVP, et al, eds. American Joint Committe on Cancer. Manual for Staging of Cancer. 4th ed. Philadelphia, PA: JB Lippincott; 1988:75-82.
20. Yarden Y, Kuang WJ, Yang-Feng T, et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. Embo J 1987; 6:3341-3351.
21. Small D, Levenstein M, Kim E, et al. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci U S A 1994; 91:459-463.
22. Ishikawa K, Komuro T, Hirota S, et al. Ultrastructural identification of the c-kit-expressing interstitial cells in the rat stomach: a comparison of control and Ws/Ws mutant rats. Cell Tissue Res 1997; 289:137-143.
23. Nocka K, Majumder S, Chabot B, et al. Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice-evidence for an impaired c-kit kinase in mutant mice. Genes Dev 1989; 3:816-826.
24. Lavin ST, Southwell BR, Murphy R, et al. Activation of neurokinin 1 receptors on interstitial cells of Cajal of the guinea-pig small intestine by substance P. Histochem Cell Biol 1998; 110:263-271.
25. Kluppel M, Huizinga JD, Malysz J, et al. Development origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine. Dev Dyn 1998; 211:60-71.
26. Kindblom LG, Remotti HE, Aldenborg F, et al. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 1998; 152:1259-1269.
27. Miettinen M, Lasota J. Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001; 438:1-12.
28. Corless CL, McGreevey L, Haley A, et al. KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size. Am J Pathol 2002; 160:1567-1572.
29. Heinrich MC, Griffith DJ, Druker BJ, et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 2000; 96:925-932.
30. Kondoh G, Hayasaka N, Li Q, et al. An in vivo model for receptor tyrosine kinase autocrine/paracrine activation: auto-stimulated KIT receptor acts as a tumor promoting factor in papillomavirus-induced tumorigenesis. Oncogene 1995; 10:341-347.
31. Sekido Y, Obata Y, Ueda R, et al. Preferential expression of c-kit protooncogene transcripts in small cell lung cancer. Cancer Res 1991; 51:2416-2419.
32. Toyota M, Hinoda Y, Itoh F, et al. Complementary DNA cloning and characterization of truncated form of c-kit in human colon carcinoma cells. Cancer Res 1994; 54:272-275.
33. Toyota M, Hinoda Y, Takaoka A, et al. Expression of c-kit and kit ligand and in human colon carcinoma cells. Tumour Biol 1993; 14:295-302.
34. Hornick JL, Fletcher CD. Immunohistochemical staining for KIT (CD117) in soft tissue sarcomas is very limited in distribution. Am J Clin Pathol 2002; 117:188-193.
35. Jemal A, Thomas A, Murray T, et al. Cancer Statistics, 2002. CA Cancer J Clin 2002; 52:23-47.