ATP-sensitive potassium channels mediate vasodilatation produced by calcitonin gene-related peptide in human internal mammary but not gastroepiploic arteries

European Journal of Clinical Investigation

Volumn 27, Issue 11, 1997, Pages 960-966

  Luu, T N ^a   Dashwood, M R ^b   Tadjkarimi, S ^a   Chester, A H ^a   Yacoub, M H ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Arterial bypass grafts; Autoradiography; Calcitonin gene related peptide; Endothelium; K(ATP) channels

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE TRIPHOSPHATE; CALCITONIN GENE RELATED PEPTIDE; GLIBENCLAMIDE; GLYCERYL TRINITRATE; LEMAKALIM; N(G) METHYLARGININE; POTASSIUM CHANNEL;

ARTERY GRAFT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; GASTROEPIPLOIC ARTERY; HUMAN; HUMAN TISSUE; INTERNAL MAMMARY ARTERY; PRIORITY JOURNAL; VASODILATATION;

EID: 0030856342     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1997.2200764.x     Document Type: Article

References (31)

1. Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 1982;298:240-4.
2. Rosenfeld MG, Mermod JJ, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale WW, Evans RM. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 1983;304:129-35.
3. 125I] caicitonin gene-related peptide binding sites in coronary arteries. Eur J Pharmacol 1992;219:415-25.
4. Wharton J, Polak JM, Gordon I, et al. Immunohistochemical demonstration of human cardiac innervation before and after transplantation. Circ Res 1990;66:900-12.
5. Franco Cereceda A. Calcitonin gene-related peptide and human epicardial coronary arteries: presence, release and vasodilator effects. Br J Pharmacol 1991;102:506-10.
6. Del Bianco E, Perretti F, Tramontana M, Manzini S, Geppetti P. Calcitonin gene-related peptide in rat arterial and venous vessels: sensitivity to capsaicin, bradykinin and FMLP. Agents Actions 1991;34:376-80.
7. Franco Cereceda A. Calcitonin gene-related peptide and tachykinins in relation to local sensory control of cardiac contractility and coronary vascular tone. Acta Physiol Scand Suppl 1988;569:1-63.
8. Kawasaki H, Takasaki K, Saito A, Gota K. Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature 1998;335:164-7.
9. Han SP, Naes L, Westfall TC. Calcitonin gene-related peptide is the endogenous mediator of nonadrenergic-noncholinergic vasodilation in rat mesentery. J Pharmacol Exp Ther 1990;255:423-8.
10. Saito A, Masaki T, Uchiyama Y, Lee TJ, Goto K. Calcitonin gene-related peptide and vasodilator nerves in large cerebral arteries of cats. J Pharmacol Exp Ther 1989;248:455-62.
11. Franco Cereceda A, Lundberg JM, Dahlof C. Neuropeptide Y and sympathetic control of heart contractility and coronary vascular tone. Acta Physiol Scand 1985;124:361-9.
12. Brain SD, Williams TJ, Tippins JR, Morris HR, Maclntyre I. Calcitonin gene-related peptide is a potent vasodilator. Nature 1985;313:54-6.
13. McEwan JR, Benjamin N, Larkin S, Fuller RW, Dollery CT, Maclntyre I. Vasodilatation by calcitonin gene-related peptide and by substance P: a comparison of their effects on resistance and capacitance vessels of human forearms. Circulation 1988;77:1072-80.
14. O'Neil GS, Chester AH, Allen SP et al. Endothelial function of human gastroepiploic artery. Implications for its use as a bypass graft. J Thorac Cardiovasc Surg 1991;102:561-5.
15. Kubota M, Moseley JM, Butera L, Dusting GJ, Macdonald PS, Martin TJ. Calcitonin gene-related peptide stimulates cyclic AMP formation in rat aortic smooth muscle cells. Biochem Biophys Res Commun 1985;132:88-94.
16. Luu TN, Chester AH, O'Neil GS, Tadjkarimi S, Yacoub MH. Effects of vasoactive neuropeptides in human saphenous vein. Br Heart J 1992;67:474-7.
17. Kitazono T, Heistad DD, Faraci FM. Role of ATP-sensitive K + channels in CGRP-induced dilatation of basilar artery in vivo. Am J Physiol 1993;265:H581-H585.
18. Nelson MT, Huang Y, Brayden JE, Hescheler J, Standen NB. Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels. Nature 1990;344:770-3.
19. Luu TN, Dashwood MR, Chester AH, Muddle JR, Yacoub MH. Calcitonin gene-related peptide in healthy and atheromatous human epicardial coronary arteries. Function and receptor characterization. J Vasc Res 1995;32:93-9.
20. McCormack DG, Mak JC, Coupe MO, Barnes PJ. Calcitonin gene-related peptide vasodilation of human pulmonary vessels. J Appl Physiol 1989;67:1265-70.
21. Crossman D, McEwan J, MacDermot J, MacIntyre I. Dollery CT. Human calcitonin gene-related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells. Br J Pharmacol 1987;92:695-701.
22. Gray DW, Marshall I. Nitric oxide synthesis inhibitors attenuate calcitonin gene-related peptide endothelium-dependent vasorelaxation in rat aorta. Eur J Pharmacol 1992;212:37-42.
23. Gulbenkian S, Opgaard OS, Ekman R et al. Peptidergic innervation of human epicardial coronary arteries. Circ Res 1993;73:579-88.
24. Hua XY, Sana A, Gamse R, Theodorsson Norheim E, Brodin E, Lundberg JM. Capsaicin induced release of multiple tachykinins (substance P, neurokinin A and eledoisin-like material) from guinea-pig spinal cord and ureter. Neuroscience 1986;19:313-19.
25. Franco Cereceda A, Henke H, Lundberg JM, Petermann JB, Hokfelt T, Fischer JA. Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin. Crit Care Med 1987;8:399-410.
26. Lechleitner P, Genser N, Mair J et al. Calcitonin gene-related peptide in patients with and without early reperfusion after acute myocardial infarction. Am Heart J 1992;124:1433-9.
27. Jackson WF. Arteriolar tone is determined by activity of ATP-sensitive potassium channels. Am J Physiol 1993;265:H1797-803.
28. Cocks TM, King SJ, Angus JA. Glibenclamide is a competitive antagonist of the thromboxane A2 receptor in dog coronary artery in vitro. Br J Pharmacol 1990;100:375-8.
29. Dennis T, Fournier A, Cadieux A, Pomerleau F, Jolicoeur FB, St.Pierre S, Quirion R. hCGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery. J Pharmacol Exp Ther 1990;254:123-8.
30. Mimeault M, Fournier A, Dumont Y, St Pierre S, Quirion R. Comparative affinities and antagonistic potencies of various human calcitonin gene-related peptide fragments on calcitonin gene-related peptide receptors in brain and periphery. J Pharmacol Exp Ther 1991;258:1084-90.
31. Umeda Y, Arisawa M. Characterization of calcitonin gene-related peptide (CGRP) receptors in guinea pig lung. Jpn J Pharmacol 1989;51:377-84.