Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and central cholinergic neurons in aged rats

Pharmacology Biochemistry and Behavior

Volumn 56, Issue 3, 1997, Pages 427-434

  Toide, K ^a   Shinoda, M ^a   Fujiwara, T ^a   Iwamoto, Y ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

(S) 2 (S) 2 (hydroxyacetyl) 1 pyrrolidinyl carbonyl N (ph enylmethyl) 1 pyrrolidinecarboxamide (JTP 4819); 3H choline; acetylcholine and choline content; aged rat; Alzheimer's disease; ChAT activity; Morris water maze; prolyl endopeptidase inhibitor; spatial memory; uptake

Indexed keywords

CHOLINE ACETYLTRANSFERASE; N BENZYL 2 [[2 (HYDROXYACETYL) 1 PYRROLIDINYL]CARBONYL] 1 PYRROLIDINECARBOXAMIDE; NEUROPEPTIDE; PROLYL ENDOPEPTIDASE INHIBITOR;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; HIPPOCAMPUS; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY;

ACETYLCHOLINE; AGING; ALZHEIMER DISEASE; ANIMALS; CEREBRAL CORTEX; CHOLINE O-ACETYLTRANSFERASE; DRUG EVALUATION, PRECLINICAL; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; NEURONS; PYRROLIDINES; RATS; RATS, INBRED F344; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS;

ANIMALIA;

EID: 0030959487     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00238-9     Document Type: Article

References (55)

1. Aoyagi, T.; Wada, T.; Nagai, M.; Kojima, F.; Harada, S.; Takeuchi, T.; Takahashi, H.; Hirokawa, K.; Tsumita, T. Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease. Experientia 46:94-97; 1990.
2. Bartus, R. T.; Dean III, R. L.; Beer, B.; Lippa, A. S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-417; 1982.
3. Beal, M. F.; Mazurek, M. F. Substance P-like immunoreactivity is reduced in Alzheimer's disease cerebral cortex. Neurology 37:1205-1209; 1987.
4. Coyle, J. T.; Donald, L. P.; Delong, M. R. Alzheimer's disease: A disorder of cortical cholinergic innervation. Science 219:1184-1190; 1983.
5. De Wied, D.; Gaffori, O.; Ree, J. M.; Jong, W. Central target for the behavioral effects of vasopressin neuropeptides. Nature 308:276-280; 1984.
6. Ferrier, I. N.; Cross, A. J.; Johnson, J. A.; Robrets, G. W.; Crow, T. J.; Corsellis, J. A. N.; Lee, Y. C.; O'Shaughnessy, D.; Adrian, T. J.; McGregor, G. P.; Baracesehamilton, A. J.; Bloom, S. R. Neuropeptides in Alzheimer type dementia. J. Neurol. Sci. 62:159-170; 1983.
7. Gibson, A. M.; Edwardson, J. A.; McDermott, J. R. Post mortem levels of some brain peptidases in Alzheimer's disease: Reduction in proline endopeptidase activity in cerebral cortex. Neurosci. Res. Commun. 9:73-81; 1991.
8. Giovannini, M. G.; Casamenti, F.; Nistri, A.; Paoli, F.; Pepeu, G. Effect of thyrotropin releasing hormone (TRH) on acetylcholine release from different brain areas investigated by microdialysis. Br. J. Pharmacol. 102:363-368; 1991.
9. 3H] dopa in various regions of the brain. J. Neurochem. 13: 655-669; 1966.
10. Griffiths, E. C.; Baris, C.; Visser, T. J.; Klootwijk, W. Thyrotropin- releasing hormone inactivation by human postmortem brain. Regul. Peptides 10:145-155; 1985.
11. Hasenohrl, R. U.; Huston, J. P.; Schuurman, T. Neuropeptide substance P improves water maze performance in aged rats. Psychopharmacology 101:23-26; 1990.
12. Husain, M. M.; Nemeroff, C. B. Neuropeptides and Alzheimer's disease. J. Am. Geriatr. Soc. 38:918-925; 1990.
13. Huston, J. P.; Hasenohrl, R. U.; Gerhardt, P.; Schwarting, R. K. W. Sequences-specific effects of neurokinin substance P on memory, reinforcement and brain dopamine activity. Psychopharmacology 112:147-162, 1993.
14. Ichai, C.; Chevallier, N.; Delaere, P.; Dournaud, P.; Epelbaum, J.; Hauw, J. J.; Vincent, J. J.; Checler, F. Influence of region-specific alterations of neuropeptidase content on the catabolic fates of neuropeptides in Alzheimer's disease. J. Neurochem. 62:645-655; 1994.
15. Iwasaki, Y.; Kinoshita, M.; Ikeda, K.; Takamiya, K.; Shiojima, T. Tropic effect of various neuropeptides on the cultured ventral spinal cord of rat embryo. Neurosci. lett. 101:316-320; 1989.
16. Kalwant, S.; Porter, A. G. Purification and characterization of human brain prolyl endopeptidase. Biochem. J. 276:237-244; 1991.
17. Kaneda, N.; Nagatsu, T. Highly sensitive assay for choline acetyl-transferase activity by high-performance liquid chromatography with electrochemical detection. J. Chromatogra. 341:23-30; 1985.
18. Kato, T.; Nakano, T.; Kojima, K.; Nagatsu, T.; Sakakibara, S. Changes in prolyl endopeptidase during maturation of rat brain and hydrolysis of Substance P by the purified enzyme. J. Neurochem. 35:527-535: 1980.
19. th Inter. Symp. Med. Chem. Abstr. 06; 1994.
20. Koida, M.; Walter, R. Post-proline cleaving enzyme. J. Biol. Chem. 251:7593-7599; 1976.
21. Lippa, A. S.; Pelham, R. W.; Beer, B.; Critchett, D. J.; Dean, R. L.; Bartus, R. T. Brain cholinergic dysfunction and memory in aged rats. Neurobiol. Aging 1:13-19; 1980.
22. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with folin phenol reagent. J. Biol. Chem. 193:265-275; 1951.
23. Luciano, A.; Alema, G. S.; Imperato, A.; Massimo, C.; Ramacci, M. T.; Scrocco, M. G. Aging of the cholinergic synapse in the rats hippocampus: Effect of acetyl-L-carnitine, in: Cholinergic basis for Alzheimer Therapy, In Becker, R.; Giacobini, E. Eds. Boston, Birkhauser; 1991: 134.
24. Matsuoka, N.; Maeda, N.; Yamazaki, M.; Ohkubo, Y.; Yamaguchi, I. Effect of FR121196, a novel cognitive enhancer, on the memory impairment of rats in passive avoidance and radial arm maze tasks. J. Pharmacol. Exp. Ther. 263:436-444; 1992.
25. Mattioli, R.; Schwarting, R. K.; Huston, J. P. Recovery from unilateral 6-hydroxydopamine lesion of substantia nigra promoted by the neurotachykinin substance P 1-11. Neuroscience 48:595-605; 1992.
26. McDonald, R.; White, N. M. Parallel information processing in the water maze: Evidence for independent memory systems involving dorsal striatum and hippocampus. Behav. Neural. Biol. 61:260-270; 1994.
27. Miyazaki, A.; Toide, K.; Sasaki, Y.; Ichitani, Y.; Iwasaki, T. Effects of a prolyl endopeptidase inhibitor, JTP-4819, on radial maze performance in hippocampal-lesioned rats. Jpn. J. Psychopharmacol. 15:522, 1995.
28. Morris, R. G. M. Spatial localization does not require the presence of local cues. Learn, motiv. 12:239-260; 1981.
29. Perry, E. K. The cholinergic hypothesis. Ten years on. Br. Med. Bull. 42:63-69; 1986.
30. 2-muscarinic receptorantagonist in aged memory-impaired rats. J. Neurosci. 15:1455-1462; 1995.
31. Rossor, M. N.; Emson, P. C.; Dawbarn, D.; Mountjoy C. Q.; Roth, M. Neuropeptide and dementia. Progr. Brain. Res. 66:143-159; 1986.
32. Sarter, M. Taking stock of cognition enhancers. Trends Pharmacol. Sci. 12:456-461; 1991.
33. Schlesinger, K.; Lipsitz, D. U.; Peck, P. L.; Pelleymounter, M. A.; Stewart, J. M.; Chase, C. N. Substance P enhancement of passive and active avoidance conditioning in mice. Pharmacol. Biochem. Behav. 19:655-661; 1983.
34. Shinoda, M.; Matsuo, A.; Toide, K. Pharmacological studies of a novelprolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion. Eur. J. Pharmacol. 305:31-38; 1996.
35. Shinoda, M.; Okamiya, K.; Toide, K. Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats. Jap. J. Pharmacol. 69:273-276; 1995.
36. Sutherland, R. J.; Rudy, J. W. Place learning in the Morris place navigation task is impaired by damage to the hippocampal formation even if the temporal demands are reduced. Psychobiology 16:157-163; 1988.
37. Taira, K.; Kaneto, H. Experimental models for studying the avoidance response in mice and the anti-amnesic effect of prolyl endopeptidase inhibitors. Folia Pharmacol. Japan. 89:243-252; 1987
38. Taylor, W. L.; Dixon, J. E. Catabolism of neuropeptides by a brain proline endopeptidase. Biochem. Biophy. Res. Commun. 94:9-15; 1980.
39. Terwel, D.; Markerink, M.; Jolles, J. Peptidases are affected differently in neocortical regions of brains from patients with Alzheimer's disease. Dementia 3:108-113; 1992.
40. Toide, K. Effects of aniracetam on one-trial passive avoidance tests and cholinergic neurons in discrete brain regions of rats. Arch. int. Pharmacodyn. 298:25-37; 1989.
41. Toide, K.; Fujiwara, T.; Iwamoto, Y.; Shinoda, M.; Okamiya, K.; Kato, T. Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain. Naunyn-Schmied. Arch. Pharm. 353:355-362; 1996.
42. Toide, K.; Iwamoto, Y.; Fujiwara, T.; Abe, H. JTP-481 9: A novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer. J. Pharmacol. Exp. Ther. 274:1370-1378; 1995.
43. Toide, K.; Iwamoto, Y.; Fujiwara, T.; Okamiya, K. A novel prolyl endopeptidase (PEP) inhibitor, JTP-4819, activates peptidergic-cholinergic neurotransmission as a cognitive enhancer: Implications and mechanism of action. In: Louilot, A.; Durkin, T.; Spampinate, U.; Cador, M., eds. Proceedings of the 6th International Conference in Neuroscience Monitoring Molecules in Neuroscience, Acheve d'imprimer sur les presses, 273-274; 1994.
44. Toide, K.; Okamiya, K.; Iwamoto, Y.; Kato, T. Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on PEP activity and substance P- and arginine-vasopressin-like immunoreactivity in the brains of aged rats. J. Neurochem. 65:234-240; 1995.
45. Toide, K.; Shinoda, M.; Takase, M.; Iwata, K.; Yoshida, H. Effects of a novel thyrotropin-releasing hormone analogue, JTP-4819, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. Eur. J. Pharmacol. 233:21-28; 1993.
46. Turner, A. J. Processing and metabolism of neuropeptides. Essays Biochem. 22:69-119; 1986.
47. Walter, R.; Shlank, H.; Glass, J. D.; Schwartz, I. L.; Kerenyi, T. D. Leucylglycinamide released from oxytocin by human enzyme. Science (Wash., DC) 173:827-829; 1971.
48. Walter, R.; Simmons, W. H.; Yoshimoto, T. Proline specific endo- and exopeptidases. Mol. Cell. Biochem. 30:111-127; 1980.
49. Whitehouse, P. J.; Price, D. L.; Struble, R. G.; Clark, A. W.; Coyle, J. T.; Delong, M. R. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 215:1237-1239; 1982.
50. Whitty, C. J.; Kapatos, G.; Bannon, M. J. Neurotropic effects of substance P on hippocampal neurons in vitro. Neurosci. Lett. 164:141-144; 1993.
51. Wilk, S. Minireview prolyl endopeptidase. Life Sci. 33:2149-2157; 1983.
52. Williams, L. R.; Rylett, R. J. Exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of Fisher 344 male rats. J. Neurochem. 55:1042-1049; 1990.
53. Yoshimoto, T. Proline specific peptidases and their specific inhibitors. Yakugaku Zasshi 111:345-358, 1991.
54. Yoshimoto, T.; Nishimura, T.; Kita, T.; Tsuru, D. Post-proline cleaving enzyme (Prolyl endopeptidase) from bovine brain. Biochemistry 94:1179-1190; 1983.
55. Yoshimoto, T.; Ogita, K.; Walter, R.; Koida, M.; Tsuru, D. Synthesis of a new fluorogenic substrate and distribution of the endopeptidase in rat tissues and body fluids of man. Biochim. Biophys. Acta. 569:184-192; 1979.