Adenoviral expression of protein-L-isoaspartyl methyltransferase (PIMT) partially attenuates the biochemical changes in PIMT-deficient mice

Journal of Neuroscience Research

Volumn 69, Issue 3, 2002, Pages 353-361

  Ogawara, Midori ^a   Takahashi, Mayumi ^a   Shimizu, Takahiko ^a   Nakajima, Mitsunari ^a   Setoguchi, Yasuhiro ^b   Shirasawa, Takuji ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

Adenovirus; Gene therapy; Isoaspartate; Neuron; PIMT deficient mice

Indexed keywords

ANTICONVULSIVE AGENT; METHYLTRANSFERASE; PROTEIN ISOASPARTYL METHYLTRANSFERASE; RECOMBINANT PIMT1; RECOMBINANT PIMT2; UNCLASSIFIED DRUG;

ADENOVIRUS; AGING; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CELL SPECIFICITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; EMBRYO; EMBRYO DEVELOPMENT; ENZYME DEFECT; ENZYME MECHANISM; EPILEPSY; FATALITY; GENE THERAPY; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE; SHORT SURVEY; SYMPTOM; VIRUS ATTENUATION; VIRUS EXPRESSION; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; BLOTTING, WESTERN; BRAIN; CELL CULTURE TECHNIQUES; EPILEPSY; FIBROBLASTS; GENE THERAPY; GENETIC VECTORS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MICE; MICE, TRANSGENIC; NEURONS; PROTEIN D-ASPARTATE-L-ISOASPARTATE METHYLTRANSFERASE; RECOMBINANT PROTEINS;

EID: 0036681983     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10302     Document Type: Short Survey

References (22)

1. Transfer of a foreign gene into the brain using adenovirus vectors
2. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors
3. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
4. Protein carboxyl methyltransferases: Two distinct classes of enzymes
5. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector
6. Aberant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in the protein-repair enzyme deficient mice
7. A simple and efficient method for purification of infectious recombinant adenovirus
8. Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice
9. Infection of replication-deficient adenoviral vector enhances IL-8 production in small airway epithelial cells more than in large airway epithelial cells
10. Alternative splicing of the human isoaspartyl protein carboxyl methyltransferase RNA leads to the generation of a C-terminal -RDEL sequence in isozyme II
11. Mouse embryos develop normally exo utero
12. Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro
13. Calcium affects the spontaneous degradation of aspartyl/asparaginyl residues in calmodulin
14. Intracellular distribution of mammalian protein kinase A catalytic subunit altered by conserved Asn2 deamidation
15. The type II isoform of bovine brain protein L-isoaspartyl methyltransferase has an endoplasmic reticulum retention signal (...RDEL) at its C-terminus
16. Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain
17. Stimulation of erythropoiesis by in vivo gene therapy: Physiologic consequences of transfer of the human erythropoietin gene to experimental animals using an adenovirus vector
18. Isoaspartate formation and neurodegeneration in Alzheimer's disease
19. Protein L-isoaspartyl methyltransferase: Developmentally regulated gene expression and protein localization in the central nervous system of aged rat
20. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
21. Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy
22. Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme