The repetitive domain of Trypanosoma cruzi trans-sialidase enhances the immune response against the catalytic domain

Journal of Infectious Diseases

Volumn 177, Issue 2, 1998, Pages 431-436

  Buscaglia, Carlos A ^b   Campetella, Oscar ^b   Leguizamón, Maria S ^b   Frasch, Alberto C C ^a  

^a UNIVERSIDAD NACIONAL DE SAN MARTÍN   (Argentina)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

SIALIDASE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA CRUZI;

EID: 0031931634     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/514199     Document Type: Article

References (15)

1. Schenkman S, Eichinger D, Pereira MEA, Nussenzweig V. Structural and functional properties of Trypanosoma trans-sialidase. Annu Rev Microbiol 1994;48:499-523.
2. Cazzulo JJ, Frasch ACC. SAPA/trans-sialidase and cruzipain: two antigens from Trypanosoma cruzi contain immunodominant but enzymatically inactive domains. FASEB J 1992;6:3259-64.
3. Schenkman S, Jiang MS, Hart GW, Nussenzweig V. A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells. Cell 1991;65:1117-26.
4. Ruiz RC, Rigoni VL, Gonzalez J, Yoshida N. The 35/50 kDa surface antigen of Trypanosoma cruzi metacyclic trypomastigotes, an adhesion molecule involved in host cell invasion. Parasite Immunol 1993;15:121-5.
5. Pereira MEA, Zhang K, Gong Y, Herrera EM, Ming M. Invasive phenotype of Trypanosoma cruzi restricted to a population expressing trans-sialidase. Infect Immun 1996;64:3884-92.
6. Chuenkova M, Pereira MEA. Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease. J Exp Med 1995;181:1693-703.
7. Pollevick G, Affranchino JL, Frasch ACC, Sanchez DO. The complete sequence of SAPA, a shed acute-phase antigen of Trypanosoma cruzi. Mol Biochem Parasitol 1991;47:247-50.
8. De Titto E, Araujo FG. Serum neuraminidase activity and hematological alterations in acute human Chagas disease. Clin Immunol Immunopathol 1988;46:157-61.
9. Leguizamón MS, Campetella OE, González Cappa SM, Frasch ACC. Mice infected with Trypanosoma cruzi produce antibodies against the enzymatic domain of trans-sialidase that inhibit its activity. Infect Immun 1994;62:3441-6.
10. Schenkman S, Chaves LB, Pontes de Carvalho L, Eichinger D. A proteolytic fragment of Trypanosoma cruzi trans-sialidase lacking the carboxyl-terminal domain is active, monomeric, and generates antibodies that inhibit enzymatic activity. J Biol Chem 1994;269:7970-5.
11. Campetella OE, Uttaro AD, Parodi AJ, Frasch ACC. A recombinant Trypanosoma cruzi trans-sialidase lacking the amino acid repeats retains the enzymatic activity. Mol Biochem Parasitol 1994;64:337-40.
12. Leguizamón MS, Campetella OE, Russomando G, et al. Antibodies inhibiting Trypanosoma cruzi trans-sialidase activity in sera from human infections. J Infect Dis 1994;170:1570-4.
13. Leguizamón MS, Russomando G, Luquetti A, et al. Long-lasting antibodies detected by a trans-sialidase inhibition assay of sera form parasite-free, serologically cured chagasic patients. J Infect Dis 1997;175:1272-5.
14. Affranchino JL, Ibáñez CF, Luquetti AO, et al. Identification of a Trypanosoma cruzi antigen that is shed during the acute phase of Chagas' disease. Mol Biochem Parasitol 1989;34:221-8.
15. Reyes MB, Lorca M, Muñoz P, Frasch ACC. Fetal IgG specificities against Trypanosoma cruzi antigens in infected newborns. Proc Natl Acad Sci USA 1990;87:2846-50.