New anti-MRSA and anti-VRE carbapenems: Synthesis and structure-activity relationships of 1β-metyl-2-(thiazol-2-ylthio)carbapenems

Journal of Antibiotics

Volumn 55, Issue 8, 2002, Pages 722-757

  Sunagawa, Makoto ^a   Itoh, Masanori ^a   Kubota, Kubota ^a   Sasaki, Akira ^a   Ueda, Yutaka ^a   Angehrn, Peter ^a   Bourson, Anne ^a   Goetschi, Erwin ^a   Hebeisen, Paul ^a   Then, Rudolf L ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1BETA METHYL 2 (4 ARYLTHIAZOL 2 YLTHIO)CARBAPENEM DERIVATIVE; 1BETA METHYL 2 (THIAZOL 2 YLTHIO) CARBAPENEM DERIVATIVE; 3 [[4 [3 [AMINO(IMINO)METHYL]PHENYL] 1,3 THIAZOL 2 YL]THIO] 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 3 [[4 [4 [AMINO(IMINO)METHYL]PHENYL] 1,3 THIAZOL 2 YL]THIO] 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 1 AZABICYCLO[3.2.0.]HEPT 2 ENE 2 CARBOXYLIC ACID; 3 [[4 [5 [[1 (2 AMINO 2 OXOETHYL)PYRROLIDINIUM 1 YL]METHYL]THIEN 2 YL] 1,3 THIAZOL 2 YL]THIO] 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 3 [[4 [5 [[ETHYL(DIMETHYL)AMMONIO]METHYL]THIEN 2 YL] 1,3 THIAZOL 2 YL]THIO] 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 1 AZABICYCLO[3.2.0HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 3 [[4 [5 [[(2 HYDROXYETHYL)(DIMETHYL)AMMONIO]METHYL]THIEN 2 YL] 1,3 THIAZOL 2 YL]THIO] 4 METHYL 7 OXO 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 3 [[4 [5 [[1 (2 HYDROXYETHYL)PYRROLIDINIUM 1 YL]METHYL]THIEN 2 YL] 1,3 THIAZOL 2 YL]THIO] 4 METHYL 7 OXO 1 AZABICCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 3 [[4 [3 [(1 METHYLPYRROLIDINIUM 1 YL)METHYL]PHENYL] 1,3 THIAZOL 2 YL]THIO] 7 OXO 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 3 [[4 [4 [(1 METHYL 1H IMIDAZOL 3 IUM 3 YL)METHYL]PHENYL] 1,3 THIAZOL 2 YL]THIO] 7 OXO 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 3 [[4 [5 [(1 METHYL 1H IMIDAZOL 3 IUM 3 YL)METHYL]THIEN 2 YL] 1,3 THIAZOL 2 YL]THIO] 7 OXO 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 3 [[4 [5 [(1 METHYLPYRROLIDINIUM 1 YL)METHYL]THIEN 2 YL] 1,3 THIAZOL 2 YL]THIO] 7 OXO 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 3 [(4PIPERIDIN 4 YL 1,3 THIAZOL 2 YL)THIO] 1 AZABICYCLO [3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 3 [[4 (1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1,3 THIAZOL 2 YL]THIO] 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 3 [[4 [3 (PYRIDIUM 1 YLMETHYL)PHENYL] 1,3 THIAZOL 2 YL] THIO] 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 3 [[4 [4 (PYRIDINIUM 1 YLMETHYL)PHENYL] 1,3 THIAZOL 2 YL] THIO] 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 3 [[4 [5 (PYRIDINIUM 1 YLMETHYL)THIEN 2 YL] 1,3 THIAZOL 2 YL]THIO] 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; 6 [1 HYDROXYETHYL] 4 METHYL 7 OXO 3 [[4 [PYRROLIDIN 3 YL] 1,3 THIAZOL 2 YL]THIO] 1 AZABICYCLO[3.2.0]HEPT 2 ENE 2 CARBOXYLIC ACID; ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE; IMIPENEM; ISOQUINOLINE DERIVATIVE; LINEZOLID; MEROPENEM; PYRIDINE DERIVATIVE; SM 17466; SM 197436; SM 232721; SM 232724; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC BIOSYNTHESIS; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENTEROCOCCUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

EID: 0036672350     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.55.722     Document Type: Article

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