Effects of endothelin receptor antagonists on endothelin-1 and inducible nitric oxide synthase genes in a rat endotoxic shock model

Clinical Science

Volumn 103, Issue SUPPL. 48, 2002, Pages

  Hirata, Yukio ^a   Ishimaru, Shinya ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

ETA receptor; ETB receptor; Lipopolysaccharide; Nitric oxide

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; NITRIC OXIDE SYNTHASE; TAK 044;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; HEMODYNAMICS; HYPOTENSION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEPTIC SHOCK; SURVIVAL RATE;

EID: 0036670319     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs103s332s     Document Type: Conference Paper

References (14)

1. Endothelins
2. Endothelin antagonists
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4. Bosentan-improved cardiopulmonary vascular performance and increased plasma levels of endothelin-1 in porcine endotoxin shock
5. A novel method for real time quantitative RT-PCR
6. Plasma endothelin levels are increased during septic shock
7. Increased concentrations of endothelin-1 messenger RNA in tissues and endothelin-1 peptide in plasma in septic pigs: Modulation by betamethasone
8. Elevation of plasma endothelin concentrations during endotoxin shock in dogs
9. Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat
10. Improvement of renal dysfuncton in dogs with endotoxemia by a nonselective endothelin receptor antagonist
11. Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels
12. Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries
13. Comparison of the effects of selective endothelin ETA and ETB receptor antagonists in congestive heart failure
14. Clearance of circulating endothelin-1 by ETB receptors in rats