The immunosuppressive drug mycophenolic acid reduces endothelin-1 synthesis in endothelial cells and renal epithelial cells

Clinical Science

Volumn 103, Issue SUPPL. 48, 2002, Pages

  Haug, Cornelia ^a   Schmid Kotsas, Alexandra ^a   Linder, Theresia ^a   Jehle, Peter M ^a   Bachem, Max G ^a   Gruenert, Adolf ^a   Rozdzinski, Eva ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Endothelial cells; Endothelin 1; Mycophenolic acid; Proximal tubule cells

Indexed keywords

CYCLOSPORIN A; DNA; ENDOTHELIN 1; IMMUNOSUPPRESSIVE AGENT; LACTATE DEHYDROGENASE; MESSENGER RNA; MYCOPHENOLIC ACID; TACROLIMUS;

CELL COUNT; CONFERENCE PAPER; CONTROLLED STUDY; DNA CONTENT; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME RELEASE; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY EPITHELIUM; KIDNEY FAILURE; KIDNEY PROXIMAL TUBULE; NEPHROTOXICITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN;

EID: 0036670240     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs103s076s     Document Type: Conference Paper

References (27)

1. Contribution of endothelin receptors in renal microvessels in acute cyclosporine-mediated vasoconstriction in rats
2. Effect of an endothelin-receptor antagonist on ischemic acute renal failure
3. A receptor antagonist in the rat
4. Endothelins in the normal and diseased kidney
5. Cyclosporine-induced synthesis of endothelin by cultured human endothelial cells
6. Endothelin release by rabbit proximal tubule cells: Modulatory effects of cyclosporine A, tacrolimus, HGF and EGF
7. FK 506 mechanism of nephrotoxicity: Stimulatory effect on endothelin secretion by cultured kidney cells and tubular cell toxicity in vitro
8. Effect of cyclosporin A on endothelin synthesis by cultured human renal cortical epithelial cells
9. Stimulation of endothelin mRNA and secretion in human endothelial cells by FK 506
10. Mycophenolate mofetil
11. Improvement of impaired renal function in heart transplant recipients treated with mycophenolate mofetil and low-dose cyclosporine
12. Mycophenolate mofetil in renal transplant recipients with cyclosporine-associated nephrotoxicity
13. Mycophenolate mofetil monotherapy in stable liver transplant patients with cyclosporine-induced renal impairment
14. Improvement of drug-induced chronic renal failure in lung transplantation
15. Mycophenolate mofetil-based, cyclosporine-free induction and maintenance immunosuppression
16. A simple, rapid and sensitive DNA assay procedure
17. Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin
18. Molecular structure of the human cytoplasmic β-actin gene: Interspecies homology of sequences in the introns
19. Acute cyclosporine-induced renal vasoconstriction is mediated by endothelin-1
20. Role of endothelin in FK 506-induced renal hypoperfusion in rats
21. FK506-induced endothelin release by cultured rat mesangial cells
22. Cyclosporine A induces endothelin-1 release from cultured rat vascular smooth muscle cells
23. Effects of BQ-123 on renal function and acute cyclosporine-induced renal dysfunction
24. Pharmacokinetics of mycophenolic acid (MPA) and determinants of MPA free fraction in pediatric and adult renal transplant recipients
25. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: Role of deoxyguanosine nucleotide depletion
26. Effects of mycophenolic acid on human renal proximal and distal tubular cells in vitro
27. Different inhibitory effects of immunosuppressive drugs on human and rat aortic smooth muscle and endothelial cell proliferation stimulated by platelet-derived growth factor or endothelial cell growth factor