Preferential binding of the anticancer drug rViscumin (recombinant mistletoe lectin) to terminally α2-6-sialylated neolacto-series gangliosides

Glycobiology

Volumn 12, Issue 8, 2002, Pages 485-497

  Müthing, Johannes ^a   Burg, Monika ^b   Möckel, Babette ^c   Langer, Martin ^c   Metelmann Strupat, Wolfgang ^a   Werner, Andreas ^b   Neumann, Ulrich ^d   Peter Katalinic, Jasna ^a   Eck, Jürgen ^e  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b BIELEFELD UNIVERSITY   (Germany)

^c VISCUM AG   (Germany)

^d UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^e BRAIN AG   (Germany)

Author keywords

Gangliosides; Glycosphingolipids; Recombinant viscumin; Ricin; TLC immunostaining

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOHYDRATE BINDING PROTEIN; CELL RECEPTOR; CERAMIDE DERIVATIVE; GALACTOSE; GALAPTIN; GANGLIOSIDE; MONOCLONAL ANTIBODY; RIBOSOME PROTEIN; RICIN; SIALIC ACID; VISCUM ALBUM LECTIN; CELL SURFACE RECEPTOR; GLYCOSPHINGOLIPID; PLANT LECTIN; PLANT MEDICINAL PRODUCT; RECOMBINANT PROTEIN; RIBOSOME INACTIVATING PROTEIN, VISCUM; SIALIC ACID DERIVATIVE; TOXIN; VEGETABLE PROTEIN;

ALPHA CHAIN; ARTICLE; BETA CHAIN; BINDING ASSAY; BLADDER CARCINOMA; CARCINOMA CELL; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; ENZYME ACTIVE SITE; ESCHERICHIA COLI; GRANULOCYTE; HUMAN; HUMAN CELL; IC 50; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIALYLATION; ANIMAL; CARBOHYDRATE ANALYSIS; CELL CULTURE; CHEMISTRY; CHO CELL; COMPARATIVE STUDY; ENZYME SPECIFICITY; HAMSTER; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; STRUCTURE ACTIVITY RELATION;

ESCHERICHIA COLI; VISCUM; VISCUM ALBUM;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBOHYDRATE SEQUENCE; CHO CELLS; CRICETINAE; GANGLIOSIDES; GLYCOSPHINGOLIPIDS; HL-60 CELLS; HUMANS; PLANT LECTINS; PLANT PREPARATIONS; PLANT PROTEINS; PLANTS, MEDICINAL; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; RICIN; SIALIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TOXINS, BIOLOGICAL; TUMOR CELLS, CULTURED;

EID: 0036668101     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/cwf062     Document Type: Article

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