Aminoguanidine, an inducible nitric oxide synthase inhibitor, plus N-acetylcysteine treatment reduce the lipopolysaccharide-augmented hepatotoxicity in rats with cirrhosis

Human and Experimental Toxicology

Volumn 21, Issue 7, 2002, Pages 359-364

  Dogiru Abbasogilu S ^a   Balkan, J ^a   Kanbagilo O ^a   Cevikbas, U ^a   Aykac Toker, G ^a   Uysal, M ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Inducible nitric oxide synthase inhibitor; Lipopolysaccharide; Liver cirrhosis; N acetylcysteine; Oxidative stress; Thioacetamide

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALKADIENE; ALPHA TOCOPHEROL; AMINOGUANIDINE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLUTATHIONE; LIPID; MALONALDEHYDE; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; SUPEROXIDE DISMUTASE; TAP WATER; THIOACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; LIVER CIRRHOSIS; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ACETYLCYSTEINE; ANALYSIS OF VARIANCE; ANIMALS; FREE RADICAL SCAVENGERS; GUANIDINES; LIPOPOLYSACCHARIDES; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; RATS; RATS, WISTAR;

ANIMALIA; ESCHERICHIA COLI;

EID: 0036656052     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327102ht256oa     Document Type: Article

References (37)

1. The induction of lipid peroxidation by E. coli lipopolysaccharide on rat hepatocytes as an important factor in the etiology of endotoxic liver damage
2. Role of reactive oxygen intermediates in lipopolysaccharide-mediated hepatic injury in the rat
3. The effects of N-acetyl cysteine treatment and nitric oxide synthase inhibition on oxidative stress induced by E. coli endotoxin
4. The effect of N-acetyl-cysteine And ω-nitro-L-arginine methyl ester treatment on lipopolysaccharide-induced oxidative stress in lung of rats
5. Changes in tissue antioxidant enzyme activities and lipid peroxides in endotoxin-induced multiple organ failure
6. Expression of inducible nitric oxide synthase in endotoxemic rat hepatocytes is dependent on the cellular glutathione status
7. Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney
8. Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA
9. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide
10. Peroxynitrite: A two-faced metabolite of nitric oxide
11. Protective and pathological roles of nitric oxide in endotoxin shock
12. Effects of nitric oxide synthase inhibition in lipopolysaccharide-induced sepsis in mice
13. Lung protection by a thiol-containing antioxidant: N-acetylcysteine
14. N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor
15. Protective effects of N-acetyl-L-cysteine in endotoxemia
16. Effect of N-acetyl-L-cysteine on sepsis in mice
17. Prognostic value of plasma endotoxin levels in patients with cirrhosis
18. Increased sensitivity to endotoxemia in the bile duct-ligated cirrhotic rat
19. Effects of lipopolysaccharide on TNF-a production, hepatic NOS2 activity, and hepatic toxicity in rats with cirrhosis
20. Taurine has protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress
21. Measurement of nitrate and nitrite in extracellular fluids: A window to systemic nitric oxide metabolism
22. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction
23. Microsomal lipid peroxidation
24. Improved method for the determination of blood glutathione
25. Vitamin E analysis methods for animal tissues
26. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids
27. Erythrocyte superoxide dismutase activity and other parameters of copper status in rats ingesting lead acetate
28. Glutathione peroxidase activity in selenium-deficient rat liver
29. Protein measurement with the folin phenol reagent
30. Animal models of liver fibrosis
31. Stimulation of lipid peroxidation and impairment of glutathione-dependent defence system in the liver of rats repeatedly treated with carbon tetrachloride
32. Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats
33. Expression of iNOS during development of liver fibrosis in rats
34. Effects of chronic nitric oxide activation or inhibition on early hepatic fibrosis in rats with bile duct ligation
35. Selective inhibition of inducible nitric oxide synthase by aminoguanidine
36. Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia
37. N-acetylcysteine inhibits in vivo nitric oxide production by inducible nitric oxide synthase