N-acetylcysteine inhibits in vivo nitric oxide production by inducible nitric oxide synthase

Nitric Oxide - Biology and Chemistry

Volumn 5, Issue 4, 2001, Pages 349-360

  Bergamini, Stefania ^a   Rota, Cristina ^a   Staffieri, Mariagrazia ^a   Daneri, Francesca ^a   Bini, Anna ^a   Giovannini, Fabiola ^a   Tomasi, Aldo ^a   Iannone, Anna ^a   Canali, Raffaella ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione   (Italy)

Author keywords

Bacterial lipopolysaccharide; Dinitrosyl iron dithiolate complex; Electron paramagnetic resonance; Free radical; N acetylcysteine; Nitric oxide synthase; Nitrosyl hemoglobin

Indexed keywords

ACETYLCYSTEINE; BACTERIUM LIPOPOLYSACCHARIDE; CITRULLINE; DITHIOL DERIVATIVE; FREE RADICAL; HEMOGLOBIN; IRON COMPLEX; MESSENGER RNA; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME INDUCTION; ENZYME INHIBITION; HYPOTHERMIA; IN VIVO STUDY; LIVER; MALE; MONONUCLEAR CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UREA BLOOD LEVEL;

EID: 0034903034     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1006/niox.2001.0356     Document Type: Article

References (43)

1. Nitric oxide: Physiology, pathophysiology, and pharmacology
2. Endothelium-derived relaxing and contracting factors
3. Biosynthesis and metabolism of endothelium-derived nitric oxide
4. The L-arginine-nitric oxide pathway
5. Nitric oxide in septic shock
6. Nitric oxide as secretory product of mammalian cells
7. The inducible nitric oxide synthase in vascular and cardiac tissue
8. Alterations in nitric oxide production in various forms of circulatory shock
9. Inducible nitric oxide synthase in the liver: Regulation and function
10. Nonselective versus selective inhibition of inducible nitric oxide synthase in experimental endotoxic shock
11. Selective iNOS inhibition is superior to norepinephrine in the treatment of rat endotoxic shock
12. Detrimental effect of a non-selective nitric oxide synthase inhibitor on the energy state of the liver following acute endotoxemia in rabbits
13. Involvement and dual effects of nitric oxide in septic shock
14. Nitric oxide in sepsis and endotoxaemia
15. Butylated hydroxytoluene and N-acetylcysteine attenuates tumor necrosis factor-alpha (TNF-alpha) secretion and TNF-alpha mRNA expression in alveolar macrophages from human lung transplant recipients in vitro
16. N-acetylcysteine inhibits induction of No production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes
17. Nitric oxide regulates endotoxin-induced TNF-alpha production by human neutrophils
18. Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione
19. N-acetylcysteine and glutathione as inhibitors of tumor necrosis factor production
20. Effects of N-acetylcysteine in endotoxic shock
21. Does N-acetyl-L-cysteine influence cytokine response during early human septic shock?
22. N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock
23. The effects of intravenous antioxidants in patients with septic shock
24. Electron paramagnetic resonance characterization of rat neuronal NO production ex vivo
25. On the influence of allosteric effectors on the electron paramagnetic spectrum of nitric oxide hemoglobin
26. Multiple assays of the five urea cycle enzymes in human liver homogenates
27. Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction
28. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
29. Fever in rats after intravenous E. coli endotoxin administration
30. Hypothermia as an indicator of the acute effects of lipopolysaccharides: Comparison with serum levels of I11 beta, I16 and Tnf alpha
31. Isolation and identification of a paramagnetic complex from the livers of carcinogen-treated rats
32. EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft
33. EPR evidence for nitric oxide production from guanidino nitrogens of L-arginine in animal tissues in vivo
34. Nonheme iron-nitrosyl complex formation in rat hepatocytes: Detection by electron paramagnetic resonance spectroscopy
35. The L-arginine: Nitric oxide pathway
36. Prostaglandins and fever in rats
37. Fever produced in the rat by intracerebral E. coli endotoxin
38. Fever in rats after intravenous E. coli endotoxin administration
39. Nitric oxide (NO) and oxygen radicals, but not prostaglandins, modulate fever
40. S-nitrosylation of proteins with nitric oxide: Synthesis and characterization of biologically active compounds
41. Possible involvement of S-nitrosothiols in the activation of guanylate cyclase by nitroso compounds
42. Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes
43. Evidence for N-acetylcysteine-sensitive nitric oxide storage as dinitrosyl-iron complexes in lipopolysaccharide-treated rat aorta