The neurobiology of treatment response to antidepressants and mood stabilizing medications

Journal of Psychiatry and Neuroscience

Volumn 27, Issue 4, 2002, Pages 260-265

  Young, L Trevor ^a   Bakish, David ^a   Beaulieu, Serge ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Adenylate cyclase; Antidepressive agents; Antimanic agents; Apoptosis; Bipolar disorder; Brain derived neurotrophic factor; Depressive disorder; Electroconvulsive therapy; Gene expression; GTP binding proteins; Hippocampus; Lithium carbonate; Prefrontal cortex

Indexed keywords

ADENYLATE CYCLASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FLUOXETINE; LITHIUM; MESSENGER RNA; MONOAMINE OXIDASE INHIBITOR; PROTEIN BCL 2; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

AFFECTIVE NEUROSIS; AMYGDALOID NUCLEUS; ARTICLE; CELL SURVIVAL; DEPRESSION; DISEASE COURSE; DRUG MECHANISM; ELECTROCONVULSIVE THERAPY; GENE EXPRESSION REGULATION; GENE TARGETING; HIPPOCAMPUS; HUMAN; IMMUNOREACTIVITY; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; NEUROBIOLOGY; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PREFRONTAL CORTEX; TREATMENT OUTCOME;

ADENYLATE CYCLASE; ANTIDEPRESSIVE AGENTS; BRAIN; CREB-BINDING PROTEIN; CYCLIC AMP; DEPRESSIVE DISORDER, MAJOR; HUMANS; N-METHYLASPARTATE; NUCLEAR PROTEINS; TRANS-ACTIVATORS;

EID: 0036655383     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Neuronal plasticity and survival in mood disorders
2. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
3. cAMP response element-mediated gene transcription in upregulated by chronic antidepressant
4. G-protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: Effects of diagnosis, suicide, and treatment at the time of death
5. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
6. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
7. Repeated electroconvulsive shock extends the duration of enhanced gene expression for BDNF in rat brain compared with a single administration
8. Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures
9. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
10. The adult rat hippocampus contains primordial neural stem cells
11. Learning enhances adult neurogenesis in the hippocampal formation
12. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx
13. Long-term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity
14. Glycogen synthase kinase-3 beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium
15. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
16. Cyclic AMP responsiveness element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells
17. Enhancement of hippocampal neurogenesis by lithium
18. Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation
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20. Differential G-protein measures in mononuclear leukocytes of patients with bipolar mood disorder are state dependent
21. Hyperfunctional G-proteins in mononuclear leukocytes of patients with mania
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