Imaging expression of adenoviral HSV1-tk suicide gene transfer using the nucleoside analogue FIRU

European Journal of Nuclear Medicine

Volumn 29, Issue 7, 2002, Pages 939-947

  Nanda, Dharmin ^a,b,c   De Jong, Marion ^a,b,c   Vogels, Ronald ^a,b,c   Havenga, Menzo ^a,b,c   Driesse, Maarten ^a,b,c   Bakker, Willem ^a,b,c   Bijster, Magda ^a,b,c   Avezaat, Cees ^a,b,c   Cox, Peter ^a,b,c   Morin, Kevin ^a,b,c   Naimi, Ebrahim ^a,b,c   Knaus, Edward ^a,b,c   Wiebe, Leonard ^a,b,c   Smitt, Peter ^a,b,c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF ALBERTA   (Canada)

^c CRUCELL HOLLAND BV   (Netherlands)

Author keywords

Gene therapy; HSV1 tk; Imaging; Radio labelled FIRU

Indexed keywords

1 (2 FLUORO 2 DEOXY BETA DEXTRO RIBOFURANOSYL) 5 IODOURACIL; 1 (2 FLUORO 2 DEOXY BETA DEXTRO RIBOFURANOSYL) 5 TRIBUTYLSTANNYLURACIL; FIALURIDINE; IODINE 123; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; URACIL DERIVATIVE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; NUCLEOSIDE; RADIOACTIVE IODINE; RADIOPHARMACEUTICAL AGENT; TUMOR MARKER; URACIL ARABINOSIDE;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BODY DISTRIBUTION; BRAIN LEVEL; CELL LINE; CELL STRAIN; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; GLIOSARCOMA; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMAGING; IN VIVO STUDY; INCUBATION TIME; KIDNEY CLEARANCE; MOUSE; MUSCLE LEVEL; NONHUMAN; PROMOTER REGION; RADIOACTIVITY; RADIOIODINATION; RAT; SCINTILLATION CAMERA; SUICIDE GENE; TIME; TISSUE LEVEL; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENE THERAPY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; GLIOMA; HERPES SIMPLEX VIRUS 1; METABOLISM; METHODOLOGY; REPORTER GENE; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

ADENOVIRIDAE; ANIMAL; ARABINOFURANOSYLURACIL; COMPARATIVE STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, VIRAL; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; GLIOMA; HERPESVIRUS 1, HUMAN; HUMAN; IODINE RADIOISOTOPES; MICE; NUCLEOSIDES; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; TRANSDUCTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; ANIMALS; HUMANS;

EID: 0036651731     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-002-0839-9     Document Type: Article

References (36)

1. Imaging the expression of transfected genes in vivo
2. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gene therapy
3. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography
4. Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo
5. A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase
6. In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: Early kinetics of radiolabelled FIAU
7. Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir
8. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography
9. [(11)C]FMAU and [(18)F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections
10. Immunogene therapy of cancer
11. Clinical trials of adenoviral-mediated suicide gene therapy of malignant gliomas
12. Drug sensitivity ("suicide") genes for selective cancer chemotherapy
13. Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells
14. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B
15. Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells
16. Radiolabelled pyrimidine nucleosides to monitor the expression of HSV-1 thymidine kinase in gene therapy
17. 125I]iodovinyl)-2′-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy
18. Iodine-131 labelled octreotide: Not an option for somatostatin receptor therapy
19. Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors
20. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
21. Treatment of malignant gliomas with a replication competent adenoviral vectors
22. New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses
23. Analytical anion-exchange HPLC of recombinant type-5 adenoviral particles
24. Characterization of 911: A new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors
25. 131I-labeled 5-halo-1-(2-fluoro-2-deoxy-beta-D-ribofuranosyl)uracils
26. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
27. Engraftment of immune-deficient mice with human hematopoietic stem cells
28. Synergy between the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan
29. Visualizing gene expression in living mammals using a bioluminescent reporter
30. Assessing gene expression in vivo: Magnetic resonance imaging and spectroscopy
31. 188Re
32. Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals
33. 124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression
34. Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo
35. 124I-FIAU in cat and man
36. Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase