Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway

Oncology Reports

Volumn 9, Issue 4, 2002, Pages 859-862

  Okaichi, Kumio ^a   Suzuki, Keiji ^a   Morita, Naoko ^a   Ikeda, Megumi ^a   Takahashi, Haruki ^a   Matsuda, Naoki ^a   Watanabe, Masami ^a   Okumura, Yutaka ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

p53; PI3 kinase; Radiosensitivity; Wortmannin

Indexed keywords

ANDROSTANE DERIVATIVE; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; ENZYME INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; RADIOSENSITIZING AGENT; WORTMANNIN;

ARTICLE; BRAIN TUMOR; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GLIOBLASTOMA; HUMAN; METABOLISM; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; SIGNAL TRANSDUCTION; X RAY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; BRAIN NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLIOBLASTOMA; HUMANS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; X-RAYS;

EID: 0036634336     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.9.4.859     Document Type: Article

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