Increased cytotoxicity of carbon tetrachloride in a human hepatoma cell line overexpressing cytochrome P450 2E1

Journal of International Medical Research

Volumn 30, Issue 4, 2002, Pages 400-405

  Takahashi, S ^a   Takahashi, T ^a   Mizobuchi, S ^a   Matsumi, M ^a   Morita, K ^a   Miyazaki, M ^a   Namba, M ^a   Akagi, R ^a   Hirakawa, M ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Carbon tetrachloride; CYP2E1; Hepatotoxicity; HSP70; Oxidative stress

Indexed keywords

CARBON TETRACHLORIDE; CYTOCHROME P450 2E1; FREE RADICAL; HALOTHANE; HEAT SHOCK PROTEIN 70; INHALATION ANESTHETIC AGENT; ISOFLURANE; MESSENGER RNA;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; EXPOSURE; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER TOXICITY; NORTHERN BLOTTING; OXIDATIVE STRESS; PROTEIN EXPRESSION;

EID: 0036630145     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000203000406     Document Type: Article

References (18)

1. The organ toxicity of inhaled anesthetics
2. Bioactivation of halogenated hydrocarbons by cytochrome P4502E1
3. Free-radical mechanisms in tissue injury
4. Carbon tetrachloride-induced lipid peroxidation dependent on an ethanol-inducible form of rabbit liver microsomal cytochrome P-450
5. Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of p450 2E1-related cytotoxicity
6. Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1
7. Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1
8. Establishment and some characteristics of human hepatoma cell lines
9. Protective effect of heme oxygenase induction in ischemic acute renal failure
10. Prevention of halothane-induced hepatotoxicity by hemin pretreatment: Protective role of heme oxygenase-1 induction
11. Gene expression of heme oxygenase-1 during glial activation by lipopolysaccharide
12. Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s
13. Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells
14. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
15. Structure and expression of the human gene encoding major heat shock protein HSP70
16. Induction of hsp 70 in HepG2 cells in response to hepatotoxicants
17. Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response
18. Differential effects of isoflurane and halothane on the induction of heat shock proteins