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Volumn 306, Issue 1, 2002, Pages 31-39
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A liquid chromatographic-electrospray ionization-tandem mass spectrometric method for determination of buprenorphine, its metabolite, norbuprenorphine, and a coformulant, naloxone, that is suitable for in vivo and in vitro metabolism studies
a
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Author keywords
[No Author keywords available]
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Indexed keywords
DRUG PRODUCTS;
LIQUID CHROMATOGRAPHY;
LIQUIDS;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
METABOLISM;
METABOLITES;
POSITIVE IONS;
FREEZE-THAW CYCLES;
HUMAN LIVER MICROSOMES;
INTERNAL STANDARDS;
MAXIMUM CONCENTRATIONS;
PLASMA CONCENTRATION;
PRIMARY METABOLITE;
SELECTED REACTION MONITORING;
TANDEM MASS SPECTROMETRIC;
ELECTROSPRAY IONIZATION;
BUPRENORPHINE;
CYTOCHROME P450;
CYTOCHROME P450 2C19;
CYTOCHROME P450 2D6;
CYTOCHROME P450 2E1;
CYTOCHROME P450 3A4;
CYTOCHROME P450 3A5;
DRUG METABOLITE;
NALOXONE;
NORBUPRENORPHINE;
UNCLASSIFIED DRUG;
DRUG DERIVATIVE;
ACCURACY;
ANALYTIC METHOD;
ARTICLE;
CONTROLLED STUDY;
DRUG BLOOD LEVEL;
DRUG DETERMINATION;
DRUG METABOLISM;
GENE EXPRESSION;
HUMAN;
HUMAN EXPERIMENT;
HUMAN TISSUE;
IN VITRO STUDY;
IN VIVO STUDY;
LIQUID CHROMATOGRAPHY;
LIQUID LIQUID EXTRACTION;
LIVER MICROSOME;
MASS SPECTROMETRY;
NORMAL HUMAN;
PRIORITY JOURNAL;
BLOOD;
CHEMICAL MODEL;
CHEMICAL STRUCTURE;
CHEMISTRY;
DRUG EFFECT;
ELECTROSPRAY MASS SPECTROMETRY;
LIVER;
METABOLISM;
METHODOLOGY;
BUPRENORPHINE;
CHROMATOGRAPHY, LIQUID;
HUMANS;
LIVER;
MODELS, CHEMICAL;
MOLECULAR STRUCTURE;
NALOXONE;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
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EID: 0036629194
PISSN: 00032697
EISSN: None
Source Type: Journal
DOI: 10.1006/abio.2002.5673 Document Type: Article |
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Times cited : (124)
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References (29)
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