Effects of buprenorphine and naloxone in morphine-stabilized opioid addicts

Drug and Alcohol Dependence

Volumn 50, Issue 1, 1998, Pages 1-8

  Fudala, Paul J ^a   Yu, Elmer ^a   Macfadden, Wayne ^a   Boardman, Chris ^b   Nora Chiang, C ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Buprenorphine; Naloxone; Opioid dependence; Treatment

Indexed keywords

BUPRENORPHINE; MORPHINE; NALOXONE; OPIATE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ABUSE; DRUG EFFECT; DRUG WITHDRAWAL; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MAINTENANCE THERAPY; MALE; OPIATE ADDICTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANALYSIS OF VARIANCE; AREA UNDER CURVE; BEHAVIOR, ADDICTIVE; BUPRENORPHINE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS; OPIOID-RELATED DISORDERS; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS; VETERANS;

EID: 0032032020     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(98)00008-8     Document Type: Article

References (36)

1. Bickel W.K., Amass L. Buprenorphine treatment of opioid dependence: A review. Exp. Clin. Psychopharmacol. 3:1995;477-489.
2. Bickel W.K., Stitzer M.L., Liebson I.A., Bigelow G.E. Acute physical dependence in man: Effects of naloxone after brief morphine exposure. J. Pharmacol. Exp. Ther. 224:1988;126-132.
3. Bickel W.K., Stitzer M.L., Bigelow G.E., Liebson I.A., Jasinski D.R., Johnson R.E. A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts. Clin. Pharmacol. Ther. 43:1988;72-78.
4. Chowdhury A.N., Chowdhury S. Buprenorphine abuse; report from India. Br. J. Addict. 85:1990;1349-1350.
5. Diagnostic and Statistical Manual of Mental Disorders, 1987. Third edition, revised. American Psychiatric Association, Washington D.C.
6. Forsyth A.J.M., Farquhar D., Gemmell M., Shewan D., Davies J.B. The dual use of opioids and temazepam by drug injectors in Glasgow (Scotland). Drug Alcohol Depend. 32:1993;277-280.
7. Hawks, R., Chiang, C.N., 1995. (Meeting Abstract). Buprenorphine-naloxone combination drug for the treatment of drug addiction. In: Harris, L.S., (Ed.). Problems of drug dependence 1994. NIDA Research Monograph #153. National Institute on Drug Abuse, Rockville, pp. 165.
8. Heel R.C., Brogden R.N., Speight T.M., Avery G.S. Buprenorphine: A review of its pharmacological properties and therapeutic efficacy. Drugs. 17:1979;81-110.
9. Heishman S.J., Stitzer M.L., Bigelow G.E., Liebson I.A. Acute opioid physical dependence in postaddict humans: Naloxone dose effects after brief morphine exposure. J. Pharmacol. Exp. Ther. 248:1989;127-134.
10. Isbell H., Wikler A., Eisenmanm A.J., Daingerfield M., Frank K. Liability of addiction to 6-dimethylamino-4,4-diphenyl-3-heptanone (methadone, 'amidone' or '10820') in man. Arch. Intern. Med. 82:1948;362-392.
11. Jasinski D.R., Fudala P.J., Johnson R.E. Sublingual versus subcutaneous buprenorphine in opiate abusers. Clin. Pharmacol. Ther. 45:1989;513-519.
12. Jasinski, D.R., Haertzen, C.A., Henningfield, J.E., Johnson, R.E., Makhzoumi, H.M., Miyasato, K., 1981. Progress report of the NIDA Addiction Research Center. In: Harris L.S., (Ed.). Problems of Drug Dependence. NIDA Research Monograph #41. The Committee on Problems of Drug Dependence, Inc., Rockville, pp. 45-52.
13. Jasinski D.R., Pevnick J.S., Clark S.C., Griffith J.D. Therapeutic usefulness of propoxyphene napsylate in narcotic addiction. Arch. Gen. Psychiatr. 34:1977;227-233.
14. Jones, R., Mendelson, J., 1996. (Meeting Abstract). Effects of buprenorphine and naloxone combination in opiate-dependent volunteers. In: Harris L.S., (Ed.). Problems of Drug Dependence 1995. NIDA Research Monograph #162. National Institute on Drug Abuse, Rockville, pp. 344.
15. Kirby K.C., Stitzer M.L., Heishman S.J. Acute opioid physical dependence in humans: Effects of varying the morphine-naloxone interval. J. Pharmacol. Exp. Ther. 255:1990;730-737.
16. Lewis J.W. Buprenorphine. Drug Alcohol Depend. 14:1985;363-372.
17. Martin W.R., Fraser H.F. A comparative study of physiological and subjective effects of heroin and morphine administered intravenously in postaddicts. J. Pharmacol. Exp. Ther. 133:1961;388-399.
18. Mello N.K., Mendelson J.H. Behavioral pharmacology of buprenorphine. Drug Alcohol Depend. 14:1985;283-303.
19. Mendelson J., Jones R.T., Fernandez I., Welm S., Melby A.K., Baggott M.J. Buprenorphine and naloxone interactions in opiate-dependent volunteers. Clin. Pharmacol. Ther. 60:1996;105-113.
20. Moa G., Zetterstrom H. Sublingual buprenorphine as postoperative analgesic: a double-blind comparison with pethidine. Acta Anaesthesiol. Scand. 34:1990;68-71.
21. Nutt J.G., Jasinski D.R. Methadone-naloxone mixtures for use in methadone maintenance programs. I. An evaluation in man of their pharmacological feasibility. II. Demonstration of acute physical dependence. Clin. Pharmacol. Ther. 15:1974;156-166.
22. O'Connor J.J., Maloney E., Travers R., Campbell A. Buprenorphine abuse among opiate addicts. Br. J. Addict. 83:1988;1085-1087.
23. Olley J.E., Tiong G.K. Plasma levels of opioid material in man following sublingual and intravenous administration of buprenorphine: exogenous/endogenous opioid interaction? J. Pharm. Pharmacol. 40:1988;666-667.
24. Peachey J.E., Lei H. Assessment of opioid dependence with naloxone. Br. J. Addict. 83:1988;193-201.
25. Pickworth W.B., Johnson R.E., Holicky B.A., Cone E.J. Subjective and physiologic effects of intravenous buprenorphine in humans. Clin. Pharmacol. Ther. 53:1993;570-576.
26. Preston K.L., Bigelow G.E., Liebson I.A. Buprenorphine and naloxone alone and in combination in opioid-dependent humans. Psychopharmacology. 94:1988;484-490.
27. Preston K.L., Bigelow G.E., Liebson I.A. Effects of sublingually given naloxone in opioid-dependent human volunteers. Drug Alcohol Depend. 1990:1990;27-34.
28. Rainey H.B. Abuse of buprenorphine. New Zealand Med. J. 99:1986;72.
29. San L., Cami J., Fernandez T., Olie J.M., Peri J.M., Torrens M. Assessment and management of opioid withdrawal symptoms in buprenorphine-dependent subjects. Br. J. Addict. 87:1992;55-62.
30. Schuh K.J., Walsh S.L., Bigelow G.E., Preston K.L., Stitzer M.L. Buprenorphine, morphine, and naloxone effects during ascending morphine maintenance in humans. J. Pharmacol. Exp. Ther. 278:1996;836-846.
31. Stitzer M.L., Wright C., Bigelow G.E., June H.L., Felch L.J. Time course of naloxone-precipitated withdrawal after acute methadone exposure in humans. Drug Alcohol Depend. 29:1991;39-46.
32. Strain E.C., Preston K.L., Liebson I.A., Bigelow G.E. Acute effects of buprenorphine, hydromorphone, and naloxone in methadone-maintained volunteers. J. Pharmacol. Exp. Ther. 261:1992;985-993.
33. Strain E.C., Preston K.L., Liebson I.A., Bigelow G.E. Buprenorphine effects in methadone-maintained volunteers: Effects at two hours after methadone. J. Pharmacol. Exp. Ther. 272:1995;628-638.
34. Walsh S.L., June H.L., Schuh K.J., Preston K.L., Bigelow G.E., Stitzer M.L. Effects of buprenorphine and methadone in methadone-maintained subjects. Psychopharmacology. 119:1995;268-276.
35. Weinhold L.L., Preston K.L., Farre M., Liebson I.A., Bigelow G.E. Buprenorphine alone and in combination with naloxone in non-dependent humans. Drug Alcohol Depend. 30:1992;263-274.
36. Wright C., Bigelow G.E., Stitzer M.L., Liebson I.A. Acute physical dependence in man: Repeated naloxone-precipitated withdrawal after a single dose of methadone. Drug Alcohol Depend. 27:1991;139-148.